MicroRNA‐9 inhibits growth and invasion of head and neck cancer cells and is a predictive biomarker of response to plerixafor, an inhibitor of its target CXCR4

Autor: Hersi Mohamed Hersi, Nina Raulf, Joop Gaken, Najeem'deen Folarin, Mahvash Tavassoli

Publikováno v: Molecular Oncology, Vol 12, Iss 12, Pp 2023-2041 (2018)

Head and neck squamous cell carcinomas (HNSCC) are associated with poor morbidity and mortality. Current treatment strategies are highly toxic and do not benefit over 50% of patients. There is therefore a crucial need for predictive and/or prognostic

Externí odkaz: https://doaj.org/article/86f1109b229f4b6689cb2a1d53b1d8ee

MicroRNA‐9 inhibits growth and invasion of head and neck cancer cells and is a predictive biomarker of response to plerixafor, an inhibitor of its target CXCR4

Autor: Nina Raulf, Joop Gaken, Mahvash Tavassoli, Najeem’deen Folarin, Hersi Mohamed Hersi

Publikováno v: Molecular Oncology
Hersi, H M, Raulf, N D, Gaken, J, Folarin, N & Tavassoli, M 2018, ' MicroRNA-9 inhibits growth and invasion of head and neck cancer cells and is a predictive biomarker of response to plerixafor, an inhibitor of its target CXCR4 ', Molecular Oncology, vol. 12, no. 12, pp. 2023-2041 . https://doi.org/10.1002/1878-0261.12352
Molecular Oncology, Vol 12, Iss 12, Pp 2023-2041 (2018)

Head and neck squamous cell carcinomas (HNSCC) are associated with poor morbidity and mortality. Current treatment strategies are highly toxic and do not benefit over 50% of patients. There is therefore a crucial need for predictive and/or prognostic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b225b07a237f9e377cc63a0ea5d177a
http://europepmc.org/articles/PMC6275261

miR-181c-BRK1 axis plays a key role in actin cytoskeleton-dependent T cell function

Autor: Alan G. Ramsay, David Darling, Nikolaos Ioannou, Shok Ping Lim, Ghulam J. Mufti, Joop Gaken

Publikováno v: Lim, S P, Ioannou, N, Ramsay, A G, Darling, D, Gäken, J & Mufti, G J 2018, ' miR-181c-BRK1 axis plays a key role in actin cytoskeleton-dependent T cell function ', Journal of Leukocyte Biology, vol. 103, no. 5, pp. 855-866 . https://doi.org/10.1002/JLB.1A0817-325RR

MicroRNAs are short endogenous noncoding RNAs that play pivotal roles in a diverse range of cellular processes. The miR-181 family is important in T cell development, proliferation, and activation. In this study, we have identified BRK1 as a potentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23391c7103b6d2075f012ab99e39374c
https://kclpure.kcl.ac.uk/ws/files/97275036/miR_181c_BRK1_axis_plays_LIM_Accepted15February2018_GREEN_AAM.pdf

Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival

Autor: Gwyn T. Williams, Joop Gaken, Nicola J. McCarthy, Kiren Yacqub-Usman, David Darling, Farzin Farzaneh, Mark R. Pickard, Shu Uin Gan, Aytug Kizilors, Cathleen E Schulte

Publikováno v: Bioscience Reports
Kizilors, A, Pickard, M R, Schulte, C E, Yacqub-Usman, K, McCarthy, N J, Gan, S-U, Darling, D, Gäken, J, Williams, G T & Farzaneh, F 2017, ' Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival ', Bioscience Reports, vol. 37, no. 4, BSR20170843 . https://doi.org/10.1042/BSR20170843

The E3 ubiquitin ligase RNF168 is a ring finger protein that has been previously identified to play an important regulatory role in the repair of double-strand DNA breaks. In the present study, an unbiased forward genetics functional screen in mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82b90c9ce0e3ff4d0fdd9459b2529be
https://eprints.keele.ac.uk/4119/1/BSR20170843.full.pdf

Fusagene vectors: a novel strategy for the expression of multiple genes from a single cistron

Autor: Kenn C. Daniel, Jie Jiang, Marcel Kuiper, Farzin Farzaneh, Stephen J. Russell, Mahvash Tavassoli, E van Berkel, Kevin G. Ford, Joop Gaken, M Kemeny, David Darling, Joanna Galea-Lauri, Christopher S. Hughes

Transduction of cells with multiple genes, allowing their stable and co-ordinated expression, is difficult with the available methodologies. A method has been developed for expression of multiple gene products, as fusion proteins, from a single cistr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98cc2689525a819d908e3ad0da2a0856
https://ora.ox.ac.uk/objects/uuid:317383e2-2ea2-40aa-b6dc-a984c424fd3a