Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joonhong Jun"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4725 (2024)
Protein kinases are essential regulators of cell function and represent one of the largest and most diverse protein families. They are particularly influential in signal transduction and coordinating complex processes like the cell cycle. Out of the
Externí odkaz:
https://doaj.org/article/618aae278a7540c48aea3ea14c783150
Autor:
Daseul Im, Joonhong Jun, Jihyun Baek, Haejin Kim, Dahyun Kang, Hyunah Bae, Hyunwook Cho, Jung-Mi Hah
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 472-486 (2022)
Fms-like tyrosine kinase 3 (FLT3) has been verified as a therapeutic target for acute myeloid leukaemia (AML). In this study, we report a series of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazol-5-yl benzamide and phenyl urea derivatives as potent FLT3 inhi
Externí odkaz:
https://doaj.org/article/3b5f7ce66d344764bc9eb1d10213a431
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11084 (2021)
As members of the MAPK family, c-Jun-N-terminal kinases (JNKs) regulate the biological processes of apoptosis. In particular, the isoform JNK3 is expressed explicitly in the brain at high levels and is involved in the pathogenesis of neurodegenerativ
Externí odkaz:
https://doaj.org/article/8a70d9e28a464869a9270dfa8575aed4
Autor:
Youri Oh, Hoyong Jung, Hyejin Kim, Jihyun Baek, Joonhong Jun, Hyunwook Cho, Daseul Im, Jung-Mi Hah
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3865 (2021)
Polo-like kinase 1 (PLK1) plays an important role in cell cycle progression and proliferation in cancer cells. PLK1 also contributes to anticancer drug resistance and is a valuable target in anticancer therapeutics. To identify additional effective P
Externí odkaz:
https://doaj.org/article/2d04976252ae46aca27d2dc5b7556273
Autor:
Joonhong Jun, Hyungwoo Moon, Songyi Yang, Junghun Lee, Jihyun Baek, Hyejin Kim, Hyunwook Cho, Kyungrim Hwang, Soyeon Ahn, Yuro Kim, Gibeom Kim, HyunTae Kim, Hoseok Kwon, Jung-Mi Hah
Publikováno v:
Journal of Medicinal Chemistry. 66:6372-6390
Publikováno v:
European journal of medicinal chemistry. 245(Pt 1)
JNK3 is a key factor driving the pathophysiology of neuronal apoptosis. Since demonstrating the therapeutic potential of JNK3 inhibitors in Alzheimer's disease, we aimed to broaden their chemical diversity for drug development. In continuation with o
Publikováno v:
SSRN Electronic Journal.
Autor:
Hyunwook Cho, Songyi Yang, Jihyun Baek, Jung-Mi Hah, Hye Jin Kim, Hyungwoo Moon, Joonhong Jun
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 11084, p 11084 (2021)
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 11084, p 11084 (2021)
As members of the MAPK family, c-Jun-N-terminal kinases (JNKs) regulate the biological processes of apoptosis. In particular, the isoform JNK3 is expressed explicitly in the brain at high levels and is involved in the pathogenesis of neurodegenerativ
Autor:
Jihyun Baek, Hyunwook Cho, Hye Jin Kim, Jung-Mi Hah, Daseul Im, Youri Oh, Hoyong Jung, Joonhong Jun
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 3865, p 3865 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 3865, p 3865 (2021)
Polo-like kinase 1 (PLK1) plays an important role in cell cycle progression and proliferation in cancer cells. PLK1 also contributes to anticancer drug resistance and is a valuable target in anticancer therapeutics. To identify additional effective P