Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants

Autor: Daseul Im, Joonhong Jun, Jihyun Baek, Haejin Kim, Dahyun Kang, Hyunah Bae, Hyunwook Cho, Jung-Mi Hah

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 472-486 (2022)

Fms-like tyrosine kinase 3 (FLT3) has been verified as a therapeutic target for acute myeloid leukaemia (AML). In this study, we report a series of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazol-5-yl benzamide and phenyl urea derivatives as potent FLT3 inhi

Externí odkaz: https://doaj.org/article/3b5f7ce66d344764bc9eb1d10213a431

Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases

Autor: Joonhong Jun, Jihyun Baek, Dahyun Kang, Hyungwoo Moon, Hyejin Kim, Hyunwook Cho, Jung-Mi Hah

Publikováno v: European journal of medicinal chemistry. 245(Pt 1)

JNK3 is a key factor driving the pathophysiology of neuronal apoptosis. Since demonstrating the therapeutic potential of JNK3 inhibitors in Alzheimer's disease, we aimed to broaden their chemical diversity for drug development. In continuation with o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16158a7e22a5a075a192830d1bab2430
https://pubmed.ncbi.nlm.nih.gov/36395646

Discovery of a Potent and Selective JNK3 Inhibitor with Neuroprotective Effect against Amyloid β-Induced Neurotoxicity in Primary Rat Neurons

Autor: Hyunwook Cho, Songyi Yang, Jihyun Baek, Jung-Mi Hah, Hye Jin Kim, Hyungwoo Moon, Joonhong Jun

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 11084, p 11084 (2021)

As members of the MAPK family, c-Jun-N-terminal kinases (JNKs) regulate the biological processes of apoptosis. In particular, the isoform JNK3 is expressed explicitly in the brain at high levels and is involved in the pathogenesis of neurodegenerativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27b8ae868be6847c8c3714354bcb798