Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Joong Sup SHIM"'
Autor:
Xiaobo Wang, Jing Huang, Fenglin Liu, Qian Yu, Ruina Wang, Jiaqi Wang, Zewen Zhu, Juan Yu, Jun Hou, Joong Sup Shim, Wei Jiang, Zengxia Li, Yuanyuan Zhang, Yongjun Dang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
Aurora A plays a critical role in G2/M transition and mitosis, making it an attractive target for cancer treatment. Aurora A inhibitors showed remarkable antitumor effects in preclinical studies, but unsatisfactory outcomes in clinical trials have gr
Externí odkaz:
https://doaj.org/article/69d0aa58c0c34253814529e277855a41
Autor:
Yunfang Xiong, Ran Ke, Qingyu Zhang, Wenjun Lan, Wanjun Yuan, Karol Nga Ieng Chan, Tom Roussel, Yifan Jiang, Jing Wu, Shuai Liu, Alice Sze Tsai Wong, Joong Sup Shim, Xuanjun Zhang, Ruiyu Xie, Nelson Dusetti, Juan Iovanna, Nagy Habib, Ling Peng, Leo Tsz On Lee
Publikováno v:
Advanced Science, Vol 9, Iss 26, Pp n/a-n/a (2022)
Abstract G protein‐coupled receptors (GPCRs) are the most common and important drug targets. However, >70% of GPCRs are undruggable or difficult to target using conventional chemical agonists/antagonists. Small nucleic acid molecules, which can seq
Externí odkaz:
https://doaj.org/article/2eda5b61827140be8560c3e34fd77ae2
Publikováno v:
Open Biology, Vol 12, Iss 8 (2022)
Neurodegenerative diseases (NDs) are a diverse group of disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous systems. One of the major features of NDs, such as Alzheimer's disease
Externí odkaz:
https://doaj.org/article/667d13a9ae3d4df6ae483c1d6c5ce5eb
Autor:
Ren-Bo Ding, Ping Chen, Barani Kumar Rajendran, Xueying Lyu, Haitao Wang, Jiaolin Bao, Jianming Zeng, Wenhui Hao, Heng Sun, Ada Hang-Heng Wong, Monica Vishnu Valecha, Eun Ju Yang, Sek Man Su, Tak Kan Choi, Shuiming Liu, Kin Iong Chan, Ling-Lin Yang, Jingbo Wu, Kai Miao, Qiang Chen, Joong Sup Shim, Xiaoling Xu, Chu-Xia Deng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nasopharyngeal carcinoma (NPC) is a malignant cancer type with high morbidity in Asia, and its current molecular classification is insufficient to predict therapy outcomes. Here the authors explore NPC subtype-specific response to therapy with a phar
Externí odkaz:
https://doaj.org/article/87f829886bef4facb841e43c9c543db3
Autor:
Junfang Lyu, Eun Ju Yang, Baoyuan Zhang, Changjie Wu, Lakhansing Pardeshi, Changxiang Shi, Pui Kei Mou, Yifan Liu, Kaeling Tan, Joong Sup Shim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Retinoblastoma susceptibility gene (RB1) is frequently mutated in lung cancers. Here the authors perform chemical and genetic vulnerability screens and identify aurora A kinase (AURKA) as a synthetic lethal candidate for RB1-deficient lung cancer cel
Externí odkaz:
https://doaj.org/article/c27f425a63c3424e81e7e45850e9e42c
Autor:
Baoyuan Zhang, Junfang Lyu, Eun Ju Yang, Yifan Liu, Changjie Wu, Lakhansing Pardeshi, Kaeling Tan, Qiang Chen, Xiaoling Xu, Chu-Xia Deng, Joong Sup Shim
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 615-627 (2020)
Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therape
Externí odkaz:
https://doaj.org/article/93de3f74397b48339fd123aba8de5335
Autor:
Liyun Zhang, Conan Chen, Jie Fu, Brendan Lilley, Cynthia Berlinicke, Baranda Hansen, Ding Ding, Guohua Wang, Tao Wang, Daniel Shou, Ying Ye, Timothy Mulligan, Kevin Emmerich, Meera T Saxena, Kelsi R Hall, Abigail V Sharrock, Carlene Brandon, Hyejin Park, Tae-In Kam, Valina L Dawson, Ted M Dawson, Joong Sup Shim, Justin Hanes, Hongkai Ji, Jun O Liu, Jiang Qian, David F Ackerley, Baerbel Rohrer, Donald J Zack, Jeff S Mumm
Publikováno v:
eLife, Vol 10 (2021)
Retinitis pigmentosa (RP) and associated inherited retinal diseases (IRDs) are caused by rod photoreceptor degeneration, necessitating therapeutics promoting rod photoreceptor survival. To address this, we tested compounds for neuroprotective effects
Externí odkaz:
https://doaj.org/article/ae361e62a3fd4acc8161a7ed3eae9011
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
ARID1A is highly inactivated in cancer. Here, the authors show that ARID1A has a synthetic lethal interaction with AURKA in colorectal cancer cells and that ARID1A deficiency activates the AURKA target CDC25C, whose inhibitors also cause cell death i
Externí odkaz:
https://doaj.org/article/df2b605cb3254b96835e03cc52650794
Publikováno v:
Cells, Vol 8, Iss 5, p 389 (2019)
Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its f
Externí odkaz:
https://doaj.org/article/3271bd06ebd8441a981645e3b632f458
Autor:
Bowen Du, Joong Sup Shim
Publikováno v:
Molecules, Vol 21, Iss 7, p 965 (2016)
Epithelial–mesenchymal transition (EMT) is known to play an important role in cancer progression, metastasis and drug resistance. Although there are controversies surrounding the causal relationship between EMT and cancer metastasis, the role of EM
Externí odkaz:
https://doaj.org/article/eaca730b0c214e50b290021bb6ef7748