Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joonas A. Jamsen"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
DNA polymerase (pol) λ performs DNA synthesis in base excision and double strand break repair. How pol λ accomplishes nucleotide insertion that can lead to mutagenesis and genomic instability was unclear. Here the authors employ time-lapse crystall
Externí odkaz:
https://doaj.org/article/0259b8fb398f4a0e841fd706bae5546e
Autor:
Joonas A. Jamsen, Akira Sassa, Lalith Perera, David D. Shock, William A. Beard, Samuel H. Wilson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The authors previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP). Here they reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during double strand break repair by pol μ.
Externí odkaz:
https://doaj.org/article/1da597dd861e4c449ac7230ac323f30d
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
How DNA polymerases discriminate against oxidized and undamaged nucleotides during DNA repair is not fully understood. Here, the authors reveal high-resolution timelapse X-ray crystallography snapshots of DSB repair polymerase μ undergoing DNA synth
Externí odkaz:
https://doaj.org/article/64968d1c0b29445aac6abe67bd0ccdd1
Autor:
Joonas A. Jamsen, William A. Beard, Lars C. Pedersen, David D. Shock, Andrea F. Moon, Juno M. Krahn, Katarzyna Bebenek, Thomas A. Kunkel, Samuel H. Wilson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
DNA polymerase (pol) μ functions in DNA double-strand break repair. Here the authors use time-lapse X-ray crystallography to capture the states of pol µ during the conversion from pre-catalytic to product complex and observe a third transiently bou
Externí odkaz:
https://doaj.org/article/982a48bce8204f249e81938b26845c43
Autor:
David D. Shock, Samuel H. Wilson, Lalith Perera, Joonas A. Jamsen, William A. Beard, Akira Sassa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Reactive oxygen species (ROS) oxidize cellular nucleotide pools and cause double strand breaks (DSBs). Non-homologous end-joining (NHEJ) attaches broken chromosomal ends together in mammalian cells. Ribonucleotide insertion by DNA polymerase (pol) μ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79dc7516fa0a4c7d26eba6116ea1814
https://doaj.org/article/1da597dd861e4c449ac7230ac323f30d
https://doaj.org/article/1da597dd861e4c449ac7230ac323f30d
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Oxidized dGTP (8-oxo-7,8-dihydro-2´-deoxyguanosine triphosphate, 8-oxodGTP) insertion by DNA polymerases strongly promotes cancer and human disease. How DNA polymerases discriminate against oxidized and undamaged nucleotides, especially in error-pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac537b8c0e35048384c66bad14d5bff
http://europepmc.org/articles/PMC8024293
http://europepmc.org/articles/PMC8024293
Autor:
Lars C. Pedersen, Joonas A. Jamsen, David D. Shock, Andrea F. Moon, Samuel H. Wilson, William A. Beard, Katarzyna Bebenek, Juno M. Krahn, Thomas A. Kunkel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Nature Communications
DNA polymerase (pol) μ is a DNA-dependent polymerase that incorporates nucleotides during gap-filling synthesis in the non-homologous end-joining pathway of double-strand break repair. Here we report time-lapse X-ray crystallography snapshots of cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccdea055d338cf00b655030ee82c5d5
https://doaj.org/article/982a48bce8204f249e81938b26845c43
https://doaj.org/article/982a48bce8204f249e81938b26845c43