Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Joon W. Shim"'
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/e8eaf515d13044fc8a6c432ad76a6358
Autor:
Emma Barrett, Gabrielle Ivey, Adam Cunningham, Gary Coffman, Tyera Pemberton, Chan Lee, Prabir Patra, James B. Day, Peter H. U. Lee, Joon W. Shim
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
The glucagon-like peptide-1 receptor (GLP-1R) agonists reduce glycated hemoglobin in patients with type 2 diabetes. Mounting evidence indicates that the potential of GLP-1R agonists, mimicking a 30 amino acid ligand, GLP-1, extends to the treatment o
Externí odkaz:
https://doaj.org/article/a2169a78ce0d4aaba362d9008ac9c48e
Autor:
Ian McKnight, Regan Raines, Hunter White, Nasim Nosoudi, Chan Lee, Peter H. U. Lee, Joon W. Shim
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
Mutations of protein kinases and cytokines are common and can cause cancer and other diseases. However, our understanding of the mutability in these genes remains rudimentary. Therefore, given previously known factors which are associated with high m
Externí odkaz:
https://doaj.org/article/10e100acb9574f539920edf9af668290
Autor:
Hunter White, Ryan Webb, Ian McKnight, Kaitlyn Legg, Chan Lee, Peter H.U. Lee, Olivia Smith Spicer, Joon W. Shim
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Symptoms of normal pressure hydrocephalus (NPH) and Alzheimer’s disease (AD) are somewhat similar, and it is common to misdiagnose these two conditions. Although there are fluid markers detectable in humans with NPH and AD, determining which biomar
Externí odkaz:
https://doaj.org/article/14078c97b4004bf1b684871a41ae11b1
Publikováno v:
Healthcare Analytics, Vol 2, Iss , Pp 100094- (2022)
Post-transplantation de novo malignancy in immunosuppressed organ recipients has become a major source of death, making early cancer surveillance through diagnosis and detection important in drastically improving survival rates. The focus of this wor
Externí odkaz:
https://doaj.org/article/8424ba692f5345cd93590d7fb6a38c9a
Autor:
Regan Raines, Ian McKnight, Hunter White, Kaitlyn Legg, Chan Lee, Wei Li, Peter H. U. Lee, Joon W. Shim
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 594 (2022)
Mutations of ion channels and G-protein-coupled receptors (GPCRs) are not uncommon and can lead to cardiovascular diseases. Given previously reported multiple factors associated with high mutation rates, we sorted the relative mutability of multiple
Externí odkaz:
https://doaj.org/article/b7dbb1df400c453eba04fc37f4f19f39
Autor:
Alexandra E. Hochstetler, Hillary M. Smith, Daniel C. Preston, Makenna M. Reed, Paul R. Territo, Joon W. Shim, Daniel Fulkerson, Bonnie L. Blazer-Yost
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Hydrocephalus is a serious condition that impacts patients of all ages. The standards of care are surgical options to divert, or inhibit production of, cerebrospinal fluid; to date, there are no effective pharmaceutical treatments, to our knowledge.
Externí odkaz:
https://doaj.org/article/c2e33e57ce404967900c4dc0468b2cad
Autor:
Madeline Hart, Joshua Conrad, Emma Barrett, Kaitlyn Legg, Gabrielle Ivey, Peter H.U. Lee, Yun C. Yung, Joon W. Shim
Publikováno v:
Experimental Neurology. 366:114433
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5b1dcb4511efeaa0b3028e67a8c58ad
https://doi.org/10.1016/j.expneurol.2023.114433
https://doi.org/10.1016/j.expneurol.2023.114433
Mutations of protein kinases are common and can cause cancer and other diseases. However, our understanding of the mutability in genes encoding kinases remains rudimentary. Given previously proposed factors associated with high mutation rates, we ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d990b96cb5e4ff79dbd6c796a00e2ed
https://doi.org/10.21203/rs.3.rs-1057987/v1
https://doi.org/10.21203/rs.3.rs-1057987/v1
Autor:
Joon W. Shim, Lei Jiang, Scott A. Persohn, Stefanie Simpson, John C. Watson, Daniel H. Fulkerson, Brian P. McCarthy, Paul R. Territo, Amanda A. Riley, Bonnie L. Blazer-Yost
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Scientific Reports
Transmembrane protein 67 (TMEM67) is mutated in Meckel Gruber Syndrome type 3 (MKS3) resulting in a pleiotropic phenotype with hydrocephalus and renal cystic disease in both humans and rodent models. The precise pathogenic mechanisms remain undetermi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca146214185d39ac1ab800add101691a
http://link.springer.com/article/10.1038/s41598-018-37620-5
http://link.springer.com/article/10.1038/s41598-018-37620-5