Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Joon Kwang, Lee"'
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 64 (2022)
A series of (S)-3-(1-aminoethyl)-8-pyrimidinyl-2-phenylisoquinoline-1(2H)-ones 3a–3k was synthesized in 40–98% yield through Suzuki–Miyaura coupling using Pd(PPh3)2Cl2, Sphos, and K2CO3 in THF/H2O mixed solvent. All newly synthesized compounds
Externí odkaz:
https://doaj.org/article/eda4321930654f728106dafceaf77beb
Publikováno v:
Pharmaceuticals
A series of (S)-3-(1-aminoethyl)-8-pyrimidinyl-2-phenylisoquinoline-1(2H)-ones 3a–3k was synthesized in 40–98% yield through Suzuki–Miyaura coupling using Pd(PPh3)2Cl2, Sphos, and K2CO3 in THF/H2O mixed solvent. All newly synthesized compounds
Autor:
Tae Woo Kim, Yong Ha Chi, Joon Kwang Lee, Byoung Wook Yoo, Jae Yeol Lee, Kyung-Tae Lee, Ji Han Kim
Publikováno v:
ChemInform. 43
A series of losartan-like pyrimidin-4(3H)-one derivatives (I) are synthesized and evaluated as a novel class of AT1 receptor antagonists.
Autor:
Kyung-Tae Lee, Joon Kwang Lee, Tae Woo Kim, Ji Han Kim, Jae Yeol Lee, Yong Ha Chi, Byoung Wook Yoo
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(4)
The discovery, in vitro and in vivo studies of the highly potent AT(1) antagonist 12a (BR-A-657, Fimasartan) antagonists are presented. A series of pyrimidin-4(3H)-one derivatives as losartan analogue were synthesized and evaluated for a novel class
Autor:
Joon Kwang Lee, Jung-Hye Choi, Joo Han Lee, Min-Sang Yoo, Je Hak Kim, Kyung-Tae Lee, Jae Yeol Lee, Soo Heui Paik, Gyu Il Kim, Hye-Eun Choi, Yong Ha Chi, Ji Han Kim, Yong Park
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
Anti-angiogenesis is regarded as an effective strategy for cancer treatment, and vascular endothelial growth factor (VEGF) plays a key role in the regulations of angiogenesis and vasculogenesis. In the present study, the authors synthesized five nove
Publikováno v:
Archives of Pharmacal Research. 15:87-90
The syntheses of novel heterocyclic base modified pyrimidine nucleosides are described. 5,6-Dimethyl-4-hydroxy-3-methoxy-1-(β-D-ribofuranosyl)-2(1H)-pyridinone7 was synthesized by condensation of silylated 5,6-dimethyl-4-hydroxy-3-methoxy-2(1H)-pyri