Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Joon Il Jun"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Intestinal stem cells contribute to homeostasis through a balance between self-renewal and differentiation. Here the authors show that CCN1 is an intestinal stem cell niche factor that activates integrin αvβ3/αvβ5 signaling to regulate proliferat
Externí odkaz:
https://doaj.org/article/159198aa3f0c4ace88693c4da6fbb491
Autor:
Joon-Il Jun, Lester F. Lau
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
CCN1 is a matricellular protein with a variety of functions, including an effect on wound healing and an association with inflammation. Here, the authors identify a possible mechanism by showing that CCN1 mediates the clearance of bacterial infection
Externí odkaz:
https://doaj.org/article/484bcf6fc0ac4f8cace309d830686ffe
Intestinal stem cells (ISCs) at the crypt base contribute to intestinal homeostasis through a balance between self-renewal and differentiation. However, the molecular mechanisms regulating this homeostatic balance remain elusive. Here we show that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3c164c9350ff115eff3b479783e0ea6
https://doi.org/10.21203/rs.3.rs-1181918/v1
https://doi.org/10.21203/rs.3.rs-1181918/v1
Publikováno v:
Nature communications. 13(1)
Intestinal stem cells (ISCs) at the crypt base contribute to intestinal homeostasis through a balance between self-renewal and differentiation. However, the molecular mechanisms regulating this homeostatic balance remain elusive. Here we show that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5943cdc63c6957bfd84c16e21165b18
https://pubmed.ncbi.nlm.nih.gov/35660741
https://pubmed.ncbi.nlm.nih.gov/35660741
Autor:
Lester F. Lau, Joon Il Jun
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Expression of the matricellular protein CCN1 (CYR61) is associated with inflammation and is required for successful wound repair. Here, we show that CCN1 binds bacterial pathogen-associated molecular patterns including peptidoglycans of Gram-positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952cb90c61f52b2dcd1256b4cc699f58
https://doi.org/10.1038/s41467-020-15075-5
https://doi.org/10.1038/s41467-020-15075-5
Autor:
Joon Il Jun, Lester F. Lau
Publikováno v:
Journal of Cell Communication and Signaling. 11:15-23
The expression of Ccn2 (CTGF) has been linked to fibrosis in many tissues and pathologies, although its activities in fibroblastic cells and precise mechanism of action in fibrogenesis are still controversial. Here, we showed that CCN2 can induce cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259159b0d24b71951a7360ddb8a856f1
https://doi.org/10.1007/s12079-016-0359-1
https://doi.org/10.1007/s12079-016-0359-1
Autor:
Lester F. Lau, Joon Il Jun
Publikováno v:
The Journal of clinical investigation. 128(1)
Fibrosis is the excessive accumulation of extracellular matrix that often occurs as a wound healing response to repeated or chronic tissue injury, and may lead to the disruption of organ architecture and loss of function. Although fibrosis was previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddc1a269967bdafd27bea39ca1dde54
https://pubmed.ncbi.nlm.nih.gov/29293097
https://pubmed.ncbi.nlm.nih.gov/29293097
Autor:
Joon-Il Jun1, Lau, Lester F.1 LFLau@uic.edu
Publikováno v:
Nature Cell Biology. Jul2010, Vol. 12 Issue 7, p676-685. 10p. 1 Diagram, 2 Charts, 11 Graphs.
Autor:
Lester F. Lau, Joon Il Jun
Publikováno v:
Aging (Albany NY)
Mammalian wound healing involves the rapid synthesis and deposition of extracellular matrix (ECM) to maintain tissue integrity during repair. This process must be tightly controlled, as its deregulation may result in fibrosis, scarring, and loss of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b5be2c8559bad855cc5c77c03a4f98
https://doi.org/10.18632/aging.100201
https://doi.org/10.18632/aging.100201
Autor:
Lester F. Lau, Joon Il Jun
Publikováno v:
Nature cell biology
Cellular senescence is a recognized mechanism of tumour suppression; however, its contribution to other pathologies is not well understood. We show that the matricellular protein CCN1 (also known as CYR61; cysteine-rich protein 61), which is dynamica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07145e00207c44a8e32a27569005d182
https://doi.org/10.1038/ncb2070
https://doi.org/10.1038/ncb2070