Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joo-Leng Low"'
Autor:
Joo-Leng Low, Weina Du, Tenzin Gocha, Gokce Oguz, Xiaoqian Zhang, Ming Wei Chen, Srdan Masirevic, Daniel Guo Rong Yim, Iain Bee Huat Tan, Adaikalavan Ramasamy, Hao Fan, Ramanuj DasGupta
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102544- (2021)
Summary: Here we report a molecular docking-based approach to identify small molecules that can target the β-catenin (β-cat)-TCF4 protein-protein interaction (PPI), a key effector complex for nuclear Wnt signaling activity. Specifically, we develop
Externí odkaz:
https://doaj.org/article/e9f8357f869441d0bb1ca3addf61bffd
Autor:
Joo-Leng Low, Dawn Pingxi Lau, Xiaoqian Zhang, Xue-Lin Kwang, Neha Rohatgi, Jane Vin Chan, Fui-Teen Chong, Stephen Qi Rong Wong, Hui-Sun Leong, Matan Thangavelu Thangavelu, Shivaji Rikka, Anders Martin Jacobsen Skanderup, Daniel Shao Weng Tan, Giridharan Periyasamy, Judice Lie Yong Koh, N Gopalakrishna Iyer, Ramanuj DasGupta
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103297- (2021)
Externí odkaz:
https://doaj.org/article/efc7e7970bf04a188a2b4cbd40df635d
Autor:
Joo-Leng Low, Dawn Pingxi Lau, Xiaoqian Zhang, Xue-Lin Kwang, Neha Rohatgi, Jane Vin Chan, Fui-Teen Chong, Stephen Qi Rong Wong, Hui-Sun Leong, Matan Thangavelu Thangavelu, Shivaji Rikka, Anders Martin Jacobsen Skanderup, Daniel Shao Weng Tan, Giridharan Periyasamy, Judice Lie Yong Koh, N Gopalakrishna Iyer, Ramanuj DasGupta
Publikováno v:
EBioMedicine, Vol 64, Iss , Pp 103220- (2021)
Background: Overexpression of epidermal growth factor receptor (EGFR), and downstream pathway activation appears to be a common oncogenic driver in the majority of head and neck squamous cell cancers (HNSCCs); yet targeting EGFR for the treatment of
Externí odkaz:
https://doaj.org/article/a859aa922a95418fb03d43002f362811
Autor:
Shumei Chia, Joo-Leng Low, Xiaoqian Zhang, Xue-Lin Kwang, Fui-Teen Chong, Ankur Sharma, Denis Bertrand, Shen Yon Toh, Hui-Sun Leong, Matan T. Thangavelu, Jacqueline S. G. Hwang, Kok-Hing Lim, Thakshayeni Skanthakumar, Hiang-Khoon Tan, Yan Su, Siang Hui Choo, Hannes Hentze, Iain B. H. Tan, Alexander Lezhava, Patrick Tan, Daniel S. W. Tan, Giridharan Periyasamy, Judice L. Y. Koh, N. Gopalakrishna Iyer, Ramanuj DasGupta
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Treatment response in patient-derived models may serve as a biomarker for response in the clinic. Here, the authors use paired patient-derived mouse xenografts and patient-derived primary culture models from head and neck squamous cell carcinomas, in
Externí odkaz:
https://doaj.org/article/7f061de7c66f4a4eb132f00dff006462
Autor:
Semih Can Akıncılar, Joelle Yi Heng Chua, Qin Feng Ng, Claire Hian Tzer Chan, Zahra Eslami-S, Kaijing Chen, Joo-Leng Low, Surendar Arumugam, Luay Aswad, Clarinda Chua, Iain Beehuat Tan, Ramanuj DasGupta, Melissa Jane Fullwood, Vinay Tergaonkar
Publikováno v:
Nucleic acids research.
Transcriptional reactivation of hTERT is the limiting step in tumorigenesis. While mutations in hTERT promoter present in 19% of cancers are recognized as key drivers of hTERT reactivation, mechanisms by which wildtype hTERT (WT-hTERT) promoter is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b58bc6f7687976a8b1c08836ea43d43
https://pubmed.ncbi.nlm.nih.gov/35697349
https://pubmed.ncbi.nlm.nih.gov/35697349
Autor:
Raghuvaran Shanmugam, Mert Burak Ozturk, Joo-Leng Low, Semih Can Akincilar, Joelle Yi Heng Chua, Matan Thangavelu Thangavelu, Giridharan Periyasamy, Ramanuj DasGupta, Vinay Tergaonkar
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mutations in hTERT promoter are seen in over 19% of human cancers, irrespective of the cancer type. Understanding the molecular players that regulate Mut-hTERT promoters may help the design of effective targeting strategies to inhibit te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50d8619f3a4f5939ed7d95981748539
http://europepmc.org/articles/PMC8784157
http://europepmc.org/articles/PMC8784157
Autor:
Neha Rohatgi, Hui-Sun Leong, Anders Jacobsen Skanderup, Stephen Qi Rong Wong, Giridharan Periyasamy, Matan Thangavelu Thangavelu, Judice Lie Yong Koh, Fui-Teen Chong, Xiaoqian Zhang, Ramanuj DasGupta, N. Gopalakrishna Iyer, Dawn Pingxi Lau, Daniel Shao Weng Tan, Jane Vin Chan, Xue-Lin Kwang, Joo-Leng Low, Shivaji Rikka
Publikováno v:
EBioMedicine
EBioMedicine, Vol 64, Iss, Pp 103220-(2021)
EBioMedicine, Vol 64, Iss, Pp 103220-(2021)
Background Overexpression of epidermal growth factor receptor (EGFR), and downstream pathway activation appears to be a common oncogenic driver in the majority of head and neck squamous cell cancers (HNSCCs); yet targeting EGFR for the treatment of H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dcccf2052f09a24788f4cb30b03414
http://europepmc.org/articles/PMC7851772
http://europepmc.org/articles/PMC7851772
Autor:
Gokce Oguz, Srdan Masirevic, Gocha Tenzin, Xiaoqian Zhang, Ramanuj DasGupta, Hao Fan, Joo-Leng Low, Ming Wei Chen, Weina Du, Daniel Guo Rong Yim, Iain Beehuat Tan, Adaikalavan Ramasamy
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102544-(2021)
iScience
iScience
Summary Here we report a molecular docking-based approach to identify small molecules that can target the β-catenin (β-cat)-TCF4 protein-protein interaction (PPI), a key effector complex for nuclear Wnt signaling activity. Specifically, we develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2561c4e57ff7bee9659f181000990a6
https://doi.org/10.1016/j.isci.2021.102544
https://doi.org/10.1016/j.isci.2021.102544
Autor:
Patrick Tan, Giridharan Periyasamy, Matan Thangavelu Thangavelu, Judice L. Y. Koh, Hiang Khoon Tan, Shen Yon Toh, Daniel Shao-Weng Tan, Joo-Leng Low, Yan Su, Ankur Sharma, Thakshayeni Skanthakumar, Jacqueline S.G. Hwang, Alexander Lezhava, Iain Beehuat Tan, Hannes Hentze, Hui-Sun Leong, Shumei Chia, N. Gopalakrishna Iyer, Xue-Lin Kwang, Kok-Hing Lim, Xiaoqian Zhang, Ramanuj DasGupta, Siang Hui Choo, Fui-Teen Chong, Denis Bertrand
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
Genomics-driven cancer therapeutics has gained prominence in personalized cancer treatment. However, its utility in indications lacking biomarker-driven treatment strategies remains limited. Here we present a “phenotype-driven precision-oncology”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1661aea700392e21c2c75c5318a7f223
https://doaj.org/article/7f061de7c66f4a4eb132f00dff006462
https://doaj.org/article/7f061de7c66f4a4eb132f00dff006462
Autor:
Shanmugam, Raghuvaran, Ozturk, Mert Burak, Joo-Leng Low, Akincilar, Semih Can, Chua, Joelle Yi Heng, Thangavelu, Matan Thangavelu, Periyasamy, Giridharan, DasGupta, Ramanuj, Tergaonkar, Vinay
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 1/18/2022, Vol. 119 Issue 3, p1-11, 11p