Výsledky vyhledávání - "Joo Song Lim"

All-trans retinoic acid induces cellular senescence by up-regulating levels of p16 and p21 via promoter hypomethylation

Autor: Kyung Lib Jang, Joo Song Lim, Sun-Hye Park

Publikováno v: Biochemical and Biophysical Research Communications. 412:500-505

All-trans retinoic acid (ATRA) induces cellular senescence via up-regulation of p16 and p21; however, the action mechanism of ATRA is unknown. Here, we show that ATRA induces promoter hypomethylation of p16 and p21 via down-regulation of DNA methyltr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a1db36b6bd069386f43e9ffbc7808e
https://doi.org/10.1016/j.bbrc.2011.07.130

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Hepatitis C virus Core protein overcomes stress-induced premature senescence by down-regulating p16 expression via DNA methylation

Autor: Kyung Lib Jang, Joo Song Lim, Sun-Hye Park

Publikováno v: Cancer letters. 321(2)

Hepatitis C virus Core plays a vital role in the development of hepatocellular carcinoma; however, the mechanism is still controversial. Here, we show that Core overcomes premature senescence provoked by a reactive oxygen species inducer, H2O2, in hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c05b2f31973bae3146cb3f659b32b7c
https://pubmed.ncbi.nlm.nih.gov/22326283

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All-trans retinoic acid induces cellular senescence via upregulation of p16, p21, and p27

Autor: Joo Song Lim, Sun-Hye Park, Kyung Lib Jang

Publikováno v: Cancer letters. 310(2)

We here present a new anti-tumor mechanism of all-trans retinoic acid (ATRA). ATRA induced several biomarkers of cellular senescence including irreversible G1 arrest, morphological changes, senescence-associated β-galactosidase, and heterochromatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500ab802e09f22863fc846efe3cbdc59
https://pubmed.ncbi.nlm.nih.gov/21803488

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Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation

Autor: Sun-Hye Park, Joo Song Lim, Kyung Lib Jang, Su-Yeon Lim, Indira Tiwari

Publikováno v: Cancer letters. 310(1)

Hepatitis C virus Core plays a vital role in the development of hepatocellular carcinoma; however, its action mechanism is still controversial. Here, we showed that Core down-regulated levels of p16, resulting in inactivation of Rb and subsequent act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10bc5118023cc662601dd0a8cafe838
https://pubmed.ncbi.nlm.nih.gov/21757290

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