Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Joo Hwan No"'
Autor:
Tuyet Kha Nguyen, Hojong Jun, Johnsy Mary Louis, Ernest Mazigo, Wang-Jong Lee, Hyun Cher Youm, Jieun Shin, Douglas K Lungu, Creto Kanyemba, Md Atique Ahmed, Fauzi Muh, Se Jin Lee, Sunghun Na, Wanjoo Chun, Won Sun Park, Joo Hwan No, Min-Jae Kim, Eun-Taek Han, Jin-Hee Han
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0298087 (2024)
Malaria eradication efforts in resource-limited areas require a rapid, economical, and accurate tool for detecting of the low parasitemia. The malaria rapid diagnostic test (mRDT) is the most suitable for on-site detection of the deadliest form of ma
Externí odkaz:
https://doaj.org/article/9b1d0fdb8b2e46cc99d0df60ec99a3c1
Autor:
Ahmed H. E. Hassan, Waleed A. Bayoumi, Selwan M. El-Sayed, Trong-Nhat Phan, Yeon Ju Kim, Chae Hyeon Lee, Soo Bin Cho, Taegeun Oh, Gyeongpyo Ham, Kazem Mahmoud, Joo Hwan No, Yong Sup Lee
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A chromone-peptidyl hybrids series was synthesised and rationally repurposed towards identification of potential antileishmanial hits against visceral leishmaniasis. Three hybrids 7c, 7n, and 7h showed potential IC50 values (9.8, 10, and 12 µM, resp
Externí odkaz:
https://doaj.org/article/75c3167bf0e4457789ff5626339f4bac
Publikováno v:
Molecules, Vol 29, Iss 8, p 1835 (2024)
Leishmaniasis, an infectious disease caused by pathogenic Leishmania parasites, affects millions of people in developing countries, and its re-emergence in developed countries, particularly in Europe, poses a growing public health concern. The limita
Externí odkaz:
https://doaj.org/article/bb7a738fb8cb449f86bebe87a11f066e
Autor:
Diego Benítez, Jaime Franco, Florencia Sardi, Alejandro Leyva, Rosario Durán, Gahee Choi, Gyongseon Yang, Taehee Kim, Namyoul Kim, Jinyeong Heo, Kideok Kim, Honggun Lee, Inhee Choi, Constantin Radu, David Shum, Joo Hwan No, Marcelo A. Comini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 912-929 (2022)
Trypanothione synthetase (TryS) catalyses the synthesis of N1,N8-bis(glutathionyl)spermidine (trypanothione), which is the main low molecular mass thiol supporting several redox functions in trypanosomatids. TryS attracts attention as molecular targe
Externí odkaz:
https://doaj.org/article/d6287e9bbb0746028794672207991f63
Publikováno v:
Pathogens, Vol 13, Iss 3, p 213 (2024)
The protozoan parasite Leishmania donovani is the causative agent of visceral leishmaniasis (VL), a potentially fatal disease if left untreated. Given the limitations of current therapies, there is an urgent need for new, safe, and effective drugs. T
Externí odkaz:
https://doaj.org/article/999b9a51152a4e0b98314a7bea1e46d0
Autor:
Ahmed H.E. Hassan, Waleed A. Bayoumi, Selwan M. El-Sayed, Trong-Nhat Phan, Taegeun Oh, Gyeongpyo Ham, Kazem Mahmoud, Joo Hwan No, Yong Sup Lee
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1594 (2023)
A series of rosmarinic acid-β-amino-α-ketoamide hybrids were synthesized and rationally repurposed towards the identification of new antileishmanial hit compounds. Two hybrids, 2g and 2h, showed promising activity (IC50 values of 9.5 and 8.8 μM ag
Externí odkaz:
https://doaj.org/article/b0f7750f5dbe410483d611246996ae7e
Autor:
Ji-Hoon Park, Min-Hee Kim, Edwin Sutanto, Seok-Won Na, Min-Jae Kim, Joon Sup Yeom, Myat Htut Nyunt, Mohammed Mohieldien Abbas Elfaki, Muzamil Mahdi Abdel Hamid, Seok Ho Cha, Sisay Getachew Alemu, Kanlaya Sriprawat, Nicholas M Anstey, Matthew J Grigg, Bridget E Barber, Timothy William, Qi Gao, Yaobao Liu, Richard D Pearson, Ric N Price, Francois Nosten, Sung-Il Yoon, Joo Hwan No, Eun-Taek Han, Sarah Auburn, Bruce Russell, Jin-Hee Han
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 6, p e0010492 (2022)
Plasmodium vivax is the most widespread cause of human malaria. Recent reports of drug resistant vivax malaria and the challenge of eradicating the dormant liver forms increase the importance of vaccine development against this relapsing disease. P.
Externí odkaz:
https://doaj.org/article/3436a76552fa4fde89759ad3b0038c8a
Autor:
Ahmed H. E. Hassan, Trong-Nhat Phan, Seolmin Yoon, Cheol Jung Lee, Hye Rim Jeon, Seung-Hwan Kim, Joo Hwan No, Yong Sup Lee
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1922-1930 (2021)
A rational-based process was adopted for repurposing pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs bearing variable acyl chains, different stereochemical configuration and/or positional relationships. Structural features were highly in
Externí odkaz:
https://doaj.org/article/33781956a9284f9394ef0a3eb388e31d
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1058 (2022)
Direct growth inhibition of infectious organisms coupled with immunomodulation to counteract the immunosuppressive environment might be a beneficial therapeutic approach. Herein, a library of sulfuretin analogs were developed with potential capabilit
Externí odkaz:
https://doaj.org/article/ecfba407f9b744949221a4c660317eb9
Autor:
Kyung-Hwa Baek, Trong-Nhat Phan, Satish R. Malwal, Hyeryon Lee, Zhu-Hong Li, Silvia N. J. Moreno, Eric Oldfield, Joo Hwan No
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 670 (2022)
SQ109 is an anti-tubercular drug candidate that has completed Phase IIb/III clinical trials for tuberculosis and has also been shown to exhibit potent in vitro efficacy against protozoan parasites including Leishmania and Trypanosoma cruzi spp. Howev
Externí odkaz:
https://doaj.org/article/21fe0bd9296f49faa14a547b0d351f5a