Dual Mechanisms of Cardiac Action Potential Prolongation by 4-Oxo-Nonenal Increasing the Risk of Arrhythmia; Late Na+ Current Induction and hERG K+ Channel Inhibition

Autor: Seong-Woo Choi, Ming-Zhe Yin, Na-Kyeong Park, Joo-Han Woo, Sung-Joon Kim

Publikováno v: Antioxidants, Vol 10, Iss 7, p 1139 (2021)

4-Oxo-nonenal (4-ONE) is an endogenous lipid peroxidation product that is more reactive than 4-hydroxy-nonenal (4-HNE). We previously reported the arrhythmic potential of 4-HNE by suppression of cardiac human Ether-a-go-go Related Gene (hERG) K+ chan

Externí odkaz: https://doaj.org/article/30f9fb51df3344a5869c15a535d5ed59

Nootkatol prevents ultraviolet radiation-induced photoaging via ORAI1 and TRPV1 inhibition in melanocytes and keratinocytes

Autor: Woo Kyung Kim, Hyun Jong Kim, Da Yeong Nam, Phan Thi Lam Hong, Joo Hyun Nam, Joo Han Woo

Publikováno v: The Korean Journal of Physiology & Pharmacology. 25:87-94

Skin photoaging occurs due to chronic exposure to solar ultraviolet radiation (UV), the main factor contributing to extrinsic skin aging. Clinical signs of photoaging include the formation of deep, coarse skin wrinkles and hyperpigmentation. Although

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::023a4cf878a216f81c305b6fcc4b5cad
https://doi.org/10.4196/kjpp.2021.25.1.87

Luteolin reduces fluid hypersecretion by inhibiting TMEM16A in interleukin-4 treated Calu-3 airway epithelial cells

Autor: Joo Hyun Nam, Hyun Jong Kim, Woo Kyung Kim, Wan Namkung, Yu Ran Nam, Joo Han Woo, Yohan Seo

Publikováno v: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology

Rhinorrhea in allergic rhinitis (AR) is characterized by the secretion of electrolytes in the nasal discharge. The secretion of Cl– and HCO3– is mainly regulated by cystic fibrosis transmembrane conductance regulator (CFTR) or via the calcium-act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72911e05ad1b6da610c63cc21301555
https://doi.org/10.4196/kjpp.2020.24.4.329

Diethylstilbestrol, a Novel ANO1 Inhibitor, Exerts an Anticancer Effect on Non-Small Cell Lung Cancer via Inhibition of ANO1

Autor: Yohan Seo, Joo Han Woo, Oh Bin Kwon, Sungwoo Jo, Wan Namkung, Sungwoo Lee, Sung Baek Jeong, Seon Ju Park, Hye In Oh, Uk Yeol Moon, Sion Lee

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7100, p 7100 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 13

Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality
thus, therapeutic targets continue to be developed. Anoctamin1 (ANO1), a novel drug target considered for the treatment of NSCLC, is a Ca2+-activated chl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb23b6839868cbccf720667fcc44c122
https://www.mdpi.com/1422-0067/22/13/7100

Nootkatol prevents ultraviolet radiation-induced photoaging

Autor: Joo Han, Woo, Da Yeong, Nam, Hyun Jong, Kim, Phan Thi Lam, Hong, Woo Kyung, Kim, Joo Hyun, Nam

Publikováno v: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology

Skin photoaging occurs due to chronic exposure to solar ultraviolet radiation (UV), the main factor contributing to extrinsic skin aging. Clinical signs of photoaging include the formation of deep, coarse skin wrinkles and hyperpigmentation. Although

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38878277d0a1be6efbd141f500dd28f4
https://pubmed.ncbi.nlm.nih.gov/33361541