Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jonuelle Acosta"'
Autor:
Jonuelle Acosta, Qinglan Li, Nelson F. Freeburg, Nivitha Murali, Alexandra Indeglia, Grant P. Grothusen, Michelle Cicchini, Hung Mai, Amy C. Gladstein, Keren M. Adler, Katherine R. Doerig, Jinyang Li, Miguel Ruiz-Torres, Kimberly L. Manning, Ben Z. Stanger, Luca Busino, Maureen Murphy, Liling Wan, David M. Feldser
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The p53 tumor suppressor regulates multiple context-dependent tumor suppressive programs. Although p53 is mutated in ~90% of small cell lung cancer (SCLC) tumors, how p53 mediates tumor suppression in this context is unknown. Here, using a m
Externí odkaz:
https://doaj.org/article/ff845a6444d4462dbb8f4fdf61c394b3
Autor:
Jonuelle Acosta, Qinglan Li, Nelson F. Freeburg, Nivitha Murali, Grant P. Grothusen, Michelle Cicchini, Hung Mai, Amy C. Gladstein, Keren M. Adler, Katherine R. Doerig, Jinyang Li, Miguel Ruiz-Torres, Kimberly L. Manning, Ben Z. Stanger, Luca Busino, Liling Wan, David M. Feldser
The p53 tumor suppressor regulates multiple context-dependent tumor suppressive programs. Although p53 is mutated in ∼90% of small cell lung cancer (SCLC) tumors, how p53 mediates tumor suppression in this context is unknown. Here, using a mouse mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6f81c879d534118a229d3728ab98e34
https://doi.org/10.1101/2022.07.22.501202
https://doi.org/10.1101/2022.07.22.501202
Publikováno v:
Oncogene
Tumor suppressor genes play critical roles orchestrating anti-cancer programs that are both context dependent and mechanistically diverse. Beyond canonical tumor suppressive programs that control cell division, cell death, and genome stability, unexp
Autor:
Jonuelle Acosta, Michelle Cicchini, Camila Robles-Oteiza, Mikael J. Pittet, David M. Feldser, Brian Lauderback, Virna Cortez-Retamozo, Kate L. Stokes
Publikováno v:
Oncogenesis
Oncogenesis, Vol 8, Iss 4, Pp 1-13 (2019)
Oncogenesis, Vol 8, Iss 4, Pp 1-13 (2019)
Senescence is an important p53-controlled tumor suppressor program that not only opposes the proliferation of cancer cells but also promotes their immune-mediated clearance in certain contexts. In hepatocellular cancer, p53 induction promotes an inna