Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis.

Autor: Faust HJ; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Cheng TY; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Korsunsky I; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Watts GFM; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Gal-Oz ST; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Trim WV; Department of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Kongthong S; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Jonsson AH; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Simmons DP; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Zhang F; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Rheumatology and the Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO, USA., Padera R; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Chubinskaya S; Department of Pediatrics, Rush Medical College, Chicago, IL, USA., Wei K; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Raychaudhuri S; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Lynch L; Department of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Moody DB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. mbrenner@bwh.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 14; Vol. 15 (1), pp. 9859. Date of Electronic Publication: 2024 Nov 14.

Publisher Correction: Interferon subverts an AHR-JUN axis to promote CXCL13 ⁺ T cells in lupus.

Autor: Law C; Department of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Human Immunobiology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Synthetic Biology, Northwestern University, Evanston, IL, USA.; Center for Genetic Medicine, Northwestern University, Chicago, IL, USA., Wacleche VS; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Cao Y; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Pillai A; Department of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Human Immunobiology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Synthetic Biology, Northwestern University, Evanston, IL, USA.; Center for Genetic Medicine, Northwestern University, Chicago, IL, USA., Sowerby J; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Hancock B; Department of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Human Immunobiology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Synthetic Biology, Northwestern University, Evanston, IL, USA.; Center for Genetic Medicine, Northwestern University, Chicago, IL, USA., Horisberger A; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Bracero S; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Skidanova V; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Li Z; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Adejoorin I; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Dillon E; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Benque IJ; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Nunez DP; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Simmons DP; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Keegan J; Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA., Chen L; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Baker T; AstraZeneca, Gaithersburg, MD, USA., Brohawn PZ; AstraZeneca, Gaithersburg, MD, USA., Al-Mossawi H; AstraZeneca, Late Respiratory and Immunology, Cambridge, UK., Hao LY; Discovery Immunology, Janssen Research & Development, Spring House, PA, USA., Jones B; Discovery Immunology, Janssen Research & Development, Spring House, PA, USA., Rao N; Discovery Immunology, Janssen Research & Development, Spring House, PA, USA., Qu Y; Merck & Co., Inc., Rahway, NJ, USA., Alves SE; Merck & Co., Inc., Rahway, NJ, USA., Jonsson AH; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA., Shaw KS; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Vleugels RA; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Massarotti E; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Costenbader KH; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Lederer JA; Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA., Hultquist JF; Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Choi J; Department of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. jaehyuk.choi@northwestern.edu.; Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. jaehyuk.choi@northwestern.edu.; Center of Human Immunobiology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. jaehyuk.choi@northwestern.edu.; Center of Synthetic Biology, Northwestern University, Evanston, IL, USA. jaehyuk.choi@northwestern.edu.; Center for Genetic Medicine, Northwestern University, Chicago, IL, USA. jaehyuk.choi@northwestern.edu., Rao DA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. darao@bwh.harvard.edu.

Publikováno v: Nature [Nature] 2024 Aug; Vol. 632 (8025), pp. E6.

Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.

Autor: Dunlap G; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Wagner A; Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Meednu N; Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA., Wang R; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Zhang F; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Rheumatology and the Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO, USA., Ekabe JC; Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA., Jonsson AH; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Wei K; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Sakaue S; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nathan A; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bykerk VP; Hospital for Special Surgery, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Donlin LT; Hospital for Special Surgery, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Goodman SM; Hospital for Special Surgery, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Firestein GS; Division of Rheumatology, Allergy and Immunology, University of California, San Diego;, La Jolla, CA, USA., Boyle DL; Division of Rheumatology, Allergy and Immunology, University of California, San Diego;, La Jolla, CA, USA., Holers VM; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA., Moreland LW; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA.; Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Tabechian D; Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA., Pitzalis C; Centre for Experimental Medicine & Rheumatology, EULAR Centre of Excellence, William Harvey Research Institute, Queen Mary University of London, London, UK.; Barts Health NHS Trust, Barts Biomedical Research Centre (BRC), National Institute for Health and Care Research (NIHR), London, UK.; Department of Biomedical Sciences, Humanitas University and Humanitas Research Hospital, Milan, Italy., Filer A; Rheumatology Research Group, Institute for Inflammation and Ageing, University of Birmingham, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.; Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK.; NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK., Raychaudhuri S; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Thakar J; Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., McDavid A; Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Rao DA; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. darao@bwh.harvard.edu., Anolik JH; Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA. jennifer_anolik@urmc.rochester.edu.; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. jennifer_anolik@urmc.rochester.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jun 11; Vol. 15 (1), pp. 4991. Date of Electronic Publication: 2024 Jun 11.

Granzyme K drives a newly-intentified pathway of complement activation.

Autor: Donado CA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; These authors contributed equally: Carlos A. Donado, A. Helena Jonsson., Jonsson AH; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Current affiliation: Division of Rheumatology and the Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO, USA.; These authors contributed equally: Carlos A. Donado, A. Helena Jonsson., Theisen E; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA., Zhang F; Division of Rheumatology and the Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO, USA., Nathan A; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA.; Center for Data Sciences, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rupani KV; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA., Jones D; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA., Raychaudhuri S; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA.; Center for Data Sciences, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dwyer DF; Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA., Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 26. Date of Electronic Publication: 2024 May 26.

Synovial Tissue Insights into Heterogeneity of Rheumatoid Arthritis.

Autor: Jonsson AH; Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. annahelena.jonsson@cuanschutz.edu.

Publikováno v: Current rheumatology reports [Curr Rheumatol Rep] 2024 Mar; Vol. 26 (3), pp. 81-88. Date of Electronic Publication: 2023 Dec 29.