Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.

Autor: Park Y; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States., Pacitto A; Department of Biochemistry, University of Cambridge , Cambridge CB2 1GA, United Kingdom., Bayliss T; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Cleghorn LA; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Wang Z; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College , New York, New York 10065, United States., Hartman T; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College , New York, New York 10065, United States., Arora K; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States., Ioerger TR; Department of Computer Science and Engineering, Texas A&M University , College Station, Texas 77843, United States., Sacchettini J; Department of Biochemistry & Biophysics, Texas A&M University , College Station, Texas 77843, United States., Rizzi M; Dipartimento di Scienze del Farmaco, University of Piemonte Orientale , Via Bovio 6, 28100 Novara, Italy., Donini S; Dipartimento di Scienze del Farmaco, University of Piemonte Orientale , Via Bovio 6, 28100 Novara, Italy., Blundell TL; Department of Biochemistry, University of Cambridge , Cambridge CB2 1GA, United Kingdom., Ascher DB; Department of Biochemistry, University of Cambridge , Cambridge CB2 1GA, United Kingdom., Rhee K; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College , New York, New York 10065, United States., Breda A; Department of Biochemistry & Biophysics, Texas A&M University , College Station, Texas 77843, United States., Zhou N; Department of Biochemistry & Biophysics, Texas A&M University , College Station, Texas 77843, United States., Dartois V; Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey , Newark, New Jersey 07103, United States., Jonnala SR; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States., Via LE; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States.; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Rondebosch 7700, South Africa., Mizrahi V; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Rondebosch 7700, South Africa., Epemolu O; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Stojanovski L; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Simeons F; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Osuna-Cabello M; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Ellis L; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., MacKenzie CJ; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Smith AR; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Davis SH; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Murugesan D; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Buchanan KI; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Turner PA; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Huggett M; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Zuccotto F; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Rebollo-Lopez MJ; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Lafuente-Monasterio MJ; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Sanz O; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Diaz GS; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Lelièvre J; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Ballell L; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Selenski C; GlaxoSmithKline , 5 Crescent Drive, Philadelphia, Pennsylvania 19112, United States., Axtman M; GlaxoSmithKline , 5 Crescent Drive, Philadelphia, Pennsylvania 19112, United States., Ghidelli-Disse S; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Pflaumer H; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Bösche M; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Drewes G; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Freiberg GM; AbbVie Molecular Characterization , 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Kurnick MD; AbbVie Molecular Characterization , 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Srikumaran M; AbbVie Molecular Characterization , 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Kempf DJ; AbbVie Molecular Characterization , 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Green SR; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Ray PC; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Read K; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Wyatt P; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Barry CE 3rd; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States.; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Rondebosch 7700, South Africa., Boshoff HI; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States.

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