Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jonna Saarimäki-Vire"'
Autor:
Tom Barsby, Eliisa Vähäkangas, Jarkko Ustinov, Hossam Montaser, Hazem Ibrahim, Väinö Lithovius, Emilia Kuuluvainen, Vikash Chandra, Jonna Saarimäki-Vire, Pekka Katajisto, Ville Hietakangas, Timo Otonkoski
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112970- (2023)
Summary: Pancreatic islets regulate blood glucose homeostasis through the controlled release of insulin; however, current metabolic models of glucose-sensitive insulin secretion are incomplete. A comprehensive understanding of islet metabolism is int
Externí odkaz:
https://doaj.org/article/ce7f7f087e48409ea41c81a3c021754a
Autor:
Vikash Chandra, Hazem Ibrahim, Clémentine Halliez, Rashmi B. Prasad, Federica Vecchio, Om Prakash Dwivedi, Jouni Kvist, Diego Balboa, Jonna Saarimäki-Vire, Hossam Montaser, Tom Barsby, Väinö Lithovius, Isabella Artner, Swetha Gopalakrishnan, Leif Groop, Roberto Mallone, Decio L. Eizirik, Timo Otonkoski
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The TYK2 gene is associated with development of type 1 diabetes. Here the authors show that TYK2 regulates β-cell development, but at the same time TYK2 inhibition in the islets prevents IFNα responses and enhances their survival against CD8+ T-cel
Externí odkaz:
https://doaj.org/article/1702551117374e95b0db57f6600d8e23
Autor:
Tom Barsby, Hazem Ibrahim, Väinö Lithovius, Hossam Montaser, Diego Balboa, Eliisa Vähäkangas, Vikash Chandra, Jonna Saarimäki-Vire, Timo Otonkoski
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101711- (2022)
Summary: We present here a robust and reliable protocol by which to differentiate pancreatic islet-like aggregates (SC-islets) from human pluripotent stem cells. The 7-stage protocol mimics developmental patterning factors that induce endocrine linea
Externí odkaz:
https://doaj.org/article/0b11521ef9d64cfb9ce2ee9d1074fc39
Autor:
Anja Brboric, Svitlana Vasylovska, Jonna Saarimäki-Vire, Daniel Espes, José Caballero-Corbalan, Gunnar Larfors, Timo Otonkoski, Joey Lau
Publikováno v:
Upsala Journal of Medical Sciences, Vol 124, Iss 4, Pp 228-237 (2019)
Background: Murine boundary cap-derived neural crest stem cells (NCSCs) are capable of enhancing islet function by stimulating beta cell proliferation as well as increasing the neural and vascular density in the islets both in vitro and in vivo. This
Externí odkaz:
https://doaj.org/article/440ab6b993d443f791cac16bfe791cee
Autor:
Jonna Saarimäki-Vire, Diego Balboa, Mark A. Russell, Juha Saarikettu, Matias Kinnunen, Salla Keskitalo, Amrinder Malhi, Cristina Valensisi, Colin Andrus, Solja Eurola, Heli Grym, Jarkko Ustinov, Kirmo Wartiovaara, R. David Hawkins, Olli Silvennoinen, Markku Varjosalo, Noel G. Morgan, Timo Otonkoski
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 281-294 (2017)
Summary: Activating germline mutations in STAT3 were recently identified as a cause of neonatal diabetes mellitus associated with beta-cell autoimmunity. We have investigated the effect of an activating mutation, STAT3K392R, on pancreatic development
Externí odkaz:
https://doaj.org/article/ec346f9834cd42bbb148c06590ce525e
Autor:
Diego Balboa, Jonna Saarimäki-Vire, Daniel Borshagovski, Mantas Survila, Päivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski
Publikováno v:
eLife, Vol 7 (2018)
Insulin gene mutations are a leading cause of neonatal diabetes. They can lead to proinsulin misfolding and its retention in endoplasmic reticulum (ER). This results in increased ER-stress suggested to trigger beta-cell apoptosis. In humans, the mech
Externí odkaz:
https://doaj.org/article/b0cfaf207d5d4df1a0be08c4d59cd97f
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10881 (2010)
beta-Catenin is a multifunctional protein involved in both signalling by secreted factors of Wnt family and regulation of the cellular architecture. We show that beta-catenin stabilization in mouse midbrain-rhombomere 1 region leads to robust up-regu
Externí odkaz:
https://doaj.org/article/d85d14739e884580bb6c69ef5e37eaf0
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4341 (2009)
Conditional gene targeting strategies are progressively used to study gene function tissue-specifically and/or at a defined time period. Instrumental to all of these strategies is the generation of targeting vectors, and any methodology that would st
Externí odkaz:
https://doaj.org/article/50a05cc29cc148708d4935af03599ad2
Autor:
Timo Otonkoski, Tom Barsby, Diego Balboa, Lithovius, Hossam Montaser, Hazem Ibrahim, Jonna Saarimäki-Vire
Publikováno v:
Diabetologia. 64:630-640
Aims/hypothesis Congenital hyperinsulinism caused by mutations in the K-ATP-channel-encoding genes (KATPHI) is a potentially life-threatening disorder of the pancreatic beta cells. No optimal medical treatment is available for patients with diazoxide
Autor:
Timo Otonkoski, Tom Barsby, Joey Lau, Pekka Katajisto, Sebastian Barg, Anders Tengholm, Diego Balboa, Jouni Kvist, Hossam Montaser, Anni I. Nieminen, Eija Jokitalo, Per-Ola Carlsson, Mingyu Yang, Chandra, Lithovius, Dyachok O, Kuuluvainen E, Per-Eric Lund, Jonna Saarimäki-Vire, Jarkko Ustinov, Helena Vihinen, Näätänen A, Muhmmad Omar-Hmeadi, Hietakangas, Hazem Ibrahim
Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in stem cell-derived islet (SC-islet) generation, detailed characterization of their functional properties has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d064cd6493b091037674586fc069fb8e
https://doi.org/10.1101/2021.03.31.437748
https://doi.org/10.1101/2021.03.31.437748