Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components

Autor: Wiebe Kruijer, W. H. A. Dokter, Edo Vellenga, Jonk Luigi Johannes Cornelius, Jan Jacob Schuringa

Publikováno v: Biochemical Journal. 347:89-96

In the present study, signal transducer and activator of transcription 3 (STAT3) Ser727 phosphorylation and transactivation was investigated in relation to activation of mitogen-activated protein (MAP) kinase family members including extracellular-si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::757fdb6002dc1a1c8df9e6a021037ad3
https://doi.org/10.1042/bj3470089

Alkaline phosphatase as a treatment of sepsis-associated acute kidney injury

Autor: Jonk Luigi Johannes Cornelius, Suzanne Heemskerk, Peter Pickkers, Rosalinde Masereeuw, Johannes G. van der Hoeven, Jacques Arend, Esther Peters, Andrea van Elsas

Publikováno v: Journal of Pharmacology and Experimental Therapeutics, 344, 2-7
Journal of Pharmacology and Experimental Therapeutics, 344, 1, pp. 2-7

Item does not contain fulltext Currently there are no pharmacological therapies licensed to treat sepsis-associated acute kidney injury (AKI). Considering the high incidence and mortality of sepsis-associated AKI, there is an urgent medical need to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf37282e883ea5453eb5e4db9f4841b
https://pubmed.ncbi.nlm.nih.gov/23131595

The human lactoferrin-derived peptide hLF1-11 primes monocytes for an enhanced TLR-mediated immune response

Autor: Anne M. van der Does, Sylvia J. P. Bogaards, Marty Wulferink, Jonk Luigi Johannes Cornelius, Peter H. Nibbering, Markwin Paul Velders

Publikováno v: BioMetals, 23(3), 493-505. Springer Netherlands
BioMetals
Van Der Does, A M, Bogaards, S J P, Jonk, L, Wulferink, M, Velders, M P & Nibbering, P H 2010, ' The human lactoferrin-derived peptide hLF1-11 primes monocytes for an enhanced TLR-mediated immune response ', BioMetals, vol. 23, no. 3, pp. 493-505 . https://doi.org/10.1007/s10534-010-9322-4
BioMetals, 23(3), 493-505

Earlier we reported that the peptide corresponding to the first eleven N-terminal amino acids of human lactoferrin (hLF1-11) is active against multi-drug resistant pathogens in mice. The mechanisms underlying this anti-infective activity remain uncle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e33c3d9bde75a6c5101ee884adb01e2
https://hdl.handle.net/1887/110078

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer

Autor: C H Heldin, S Itoh, Jonk Luigi Johannes Cornelius, Wiebe Kruijer, P. ten Dijke

Publikováno v: The Journal of biological chemistry. 273(33)

Smad proteins have been identified as mediators of intracellular signal transduction by members of the transforming growth factor-beta (TGF-beta) superfamily, which affect cell proliferation, differentiation, as well as pattern formation during early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f952cee9c43f719ed56aaaeb0a25fdf
https://pubmed.ncbi.nlm.nih.gov/9694870

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