Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Joni M Mäki"'
Autor:
Riitta Kaarteenaho, Oula Norman, Jarkko Koivunen, Antti M Salo, Joni M Mäki, Johanna Myllyharju, Taina Pihlajaniemi, Anne Heikkinen
Publikováno v:
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)
Background Collagen XIII is a transmembrane collagen associated with neuromuscular junction development, and in humans its deficiency results in congenital myasthenic syndrome type 19 (CMS19), which leads to breathing difficulties. CMS19 patients usu
Externí odkaz:
https://doaj.org/article/ac36a204554a4f418330e724704750ba
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0276215 (2022)
Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with a poor prognosis and few treatment options. In the most widely used experimental model for this disease, bleomycin is administered into the lungs of mice, causing a reaction of inflamm
Externí odkaz:
https://doaj.org/article/53ad385b25ea4a57afa6042d55f2ba6a
Autor:
Chen Rachman-Tzemah, Shelly Zaffryar-Eilot, Moran Grossman, Dario Ribero, Michael Timaner, Joni M. Mäki, Johanna Myllyharju, Francesco Bertolini, Dov Hershkovitz, Irit Sagi, Peleg Hasson, Yuval Shaked
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 774-784 (2017)
Surgery remains the most successful curative treatment for cancer. However, some patients with early-stage disease who undergo surgery eventually succumb to distant metastasis. Here, we show that in response to surgery, the lungs become more vulnerab
Externí odkaz:
https://doaj.org/article/2686e8bc65004844a77588d2f1547c24
Autor:
Guillermo A, Martínez-Nieto, Hanna-Riikka, Teppo, Noora, Petrelius, Valerio, Izzi, Raman, Devarajan, Tiina, Petäistö, Hengshuo, Liu, Kris S, Kim, Sanna-Maria, Karppinen, Heli, Ruotsalainen, Jarkko, Koivunen, Joni M, Mäki, Gilbert C, Walker, Taina, Pihlajaniemi, Donald, Gullberg, Ritva, Heljasvaara
Publikováno v:
Frontiers in oncology. 12
Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing. The expression of the α11 is upregulated in cancer-associated fibroblasts (CAFs) in vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea4425cb9149d7ba006097527350b5e5
https://pubmed.ncbi.nlm.nih.gov/36003785
https://pubmed.ncbi.nlm.nih.gov/36003785
Autor:
Joona, Tapio, Riikka, Halmetoja, Elitsa Y, Dimova, Joni M, Mäki, Anu, Laitala, Gail, Walkinshaw, Johanna, Myllyharju, Raisa, Serpi, Peppi, Koivunen
Publikováno v:
The Journal of biological chemistry. 298(8)
Hypoxia-inducible factor (HIF) prolyl 4-hydroxylases (HIF-P4Hs 1-3) are druggable targets in renal anemia, where pan-HIF-P4H inhibitors induce an erythropoietic response. Preclinical data suggest that HIF-P4Hs could also be therapeutic targets for tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f75ed686c4179b4bfe7c2e818e2d5ff
https://pubmed.ncbi.nlm.nih.gov/35787374
https://pubmed.ncbi.nlm.nih.gov/35787374
Autor:
Ann-Helen, Rosendahl, Mia, Monnius, Anu, Laitala, Antti, Railo, Ilkka, Miinalainen, Ritva, Heljasvaara, Joni M, Mäki, Johanna, Myllyharju
Publikováno v:
The Journal of biological chemistry. 298(4)
Hypoxia-inducible factors (HIFs) induce numerous genes regulating oxygen homeostasis. As oxygen sensors of the cells, the HIF prolyl 4-hydroxylases (HIF-P4Hs) regulate the stability of HIFs in an oxygen-dependent manner. During hair follicle (HF) mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c76509ca7768a3b3c282244cb01fbed6
https://pubmed.ncbi.nlm.nih.gov/35247391
https://pubmed.ncbi.nlm.nih.gov/35247391
Autor:
Harri Elamaa, Mika Kaakinen, Marjut Nätynki, Zoltan Szabo, Veli-Pekka Ronkainen, Ville Äijälä, Joni M. Mäki, Risto Kerkelä, Johanna Myllyharju, Lauri Eklund
Publikováno v:
Angiogenesis. 25(2)
Hypoxia plays an important regulatory role in the vasculature to adjust blood flow to meet metabolic requirements. At the level of gene transcription, the responses are mediated by hypoxia-inducible factor (HIF) the stability of which is controlled b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc4797f245e546ec012a91f8e26bea5
https://pubmed.ncbi.nlm.nih.gov/34997404
https://pubmed.ncbi.nlm.nih.gov/34997404
Autor:
Johanna Myllyharju, Peppi Koivunen, Sofia Sova, Antti M. Salo, Joni M. Mäki, Franziska Dengler
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 4038, p 4038 (2021)
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 4038, p 4038 (2021)
The HIF prolyl 4-hydroxylases (HIF-P4H) control hypoxia-inducible factor (HIF), a powerful mechanism regulating cellular adaptation to decreased oxygenation. The gastrointestinal epithelium subsists in “physiological hypoxia” and should therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a861244a52fa9bc3e315f938e698e3b
http://urn.fi/urn:nbn:fi-fe2021070741216
http://urn.fi/urn:nbn:fi-fe2021070741216
Autor:
Moran Grossman, Dario Ribero, Michael Timaner, Francesco Bertolini, Dov Hershkovitz, Irit Sagi, Johanna Myllyharju, Peleg Hasson, Yuval Shaked, Joni M. Mäki, Shelly Zaffryar-Eilot, Chen Rachman-Tzemah
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 774-784 (2017)
Cell Reports
Cell Reports
Summary Surgery remains the most successful curative treatment for cancer. However, some patients with early-stage disease who undergo surgery eventually succumb to distant metastasis. Here, we show that in response to surgery, the lungs become more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fcbb3b906419b53e3fa606cf4328a1
http://www.sciencedirect.com/science/article/pii/S2211124717304783
http://www.sciencedirect.com/science/article/pii/S2211124717304783
Autor:
Joachim Fandrey, Peppi Koivunen, Stephan Settelmeier, Johanna Myllyharju, Joni M. Mäki, Timm Schreiber, Sandra Winning, Nadiya Byts
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0233261 (2020)
PLoS ONE, Vol 15, Iss 5, p e0233261 (2020)
The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tissue regeneration. HIF-1 is negatively controlled by O2-dependent prolyl hydroxylases with a predominant role of prolyl hydroxylase 2 isoform (Phd2). Transgenic mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0e606c70bad226cda14488a3468cdc
https://pubmed.ncbi.nlm.nih.gov/32413092
https://pubmed.ncbi.nlm.nih.gov/32413092