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Autor:
Marc Rolland, Valérie Rolland-Fulcrand, Jean Martinez, M. L. Roumestant, Jonhy Wehbe, Tarek Kassem
Publikováno v:
Tetrahedron: Asymmetry. 12:2657-2661
A short four-step synthesis of (3R,4R,5R)-4-hydroxyisoleucine lactone with total control of stereochemistry is reported, the key intermediate being the didehydroamino acid derivative arising from an aldol dehydration reaction between a glycine anion