Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jongrock Kong"'
Autor:
John A. McIntosh, Tamas Benkovics, Steven M. Silverman, Mark A. Huffman, Jongrock Kong, Peter E. Maligres, Tetsuji Itoh, Hao Yang, Deeptak Verma, Weilan Pan, Hsing-I Ho, Jonathan Vroom, Anders M. Knight, Jessica A. Hurtak, Artis Klapars, Anna Fryszkowska, William J. Morris, Neil A. Strotman, Grant S. Murphy, Kevin M. Maloney, Patrick S. Fier
Publikováno v:
ACS Central Science, Vol 7, Iss 12, Pp 1980-1985 (2021)
Externí odkaz:
https://doaj.org/article/0dca7a33b3304dad9cbbea813d344184
Autor:
Caitlin R. Lacker, Travis J. DeLano, Emily P. Chen, Jongrock Kong, Kevin M. Belyk, Tiffany Piou, Sarah E. Reisman
Publikováno v:
Journal of the American Chemical Society. 144:20190-20195
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::271f62a198aac6b93fb2c429e32705bb
https://doi.org/10.1021/jacs.2c07917
https://doi.org/10.1021/jacs.2c07917
Autor:
Caitlin R, Lacker, Travis J, DeLano, Emily P, Chen, Jongrock, Kong, Kevin M, Belyk, Tiffany, Piou, Sarah E, Reisman
Publikováno v:
Journal of the American Chemical Society. 144(44)
An asymmetric cross-coupling of α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab0c725d4ca41124c28e07320821098c
https://pubmed.ncbi.nlm.nih.gov/36288571
https://pubmed.ncbi.nlm.nih.gov/36288571
Autor:
Anna Fryszkowska, Chihui An, Oscar Alvizo, Goutami Banerjee, Keith A. Canada, Yang Cao, Duane DeMong, Paul N. Devine, Da Duan, David M. Elgart, Iman Farasat, Donald R. Gauthier, Erin N. Guidry, Xiujuan Jia, Jongrock Kong, Nikki Kruse, Katrina W. Lexa, Alexey A. Makarov, Benjamin F. Mann, Erika M. Milczek, Vesna Mitchell, Jovana Nazor, Claudia Neri, Robert K. Orr, Peter Orth, Eric M. Phillips, James N. Riggins, Wes A. Schafer, Steven M. Silverman, Christopher A. Strulson, Nandhitha Subramanian, Rama Voladri, Hao Yang, Jie Yang, Xiang Yi, Xiyun Zhang, Wendy Zhong
Publikováno v:
Science (New York, N.Y.). 376(6599)
The emergence of new therapeutic modalities requires complementary tools for their efficient syntheses. Availability of methodologies for site-selective modification of biomolecules remains a long-standing challenge, given the inherent complexity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e1c890246ba90b63af46174410e3e6
https://pubmed.ncbi.nlm.nih.gov/35709283
https://pubmed.ncbi.nlm.nih.gov/35709283
Autor:
Ian Mangion, Rebecca T. Ruck, Fred J. Fleitz, Lushi Tan, Jongrock Kong, Qinghao Chen, Nelo R. Rivera
Publikováno v:
Organic Process Research & Development. 25:405-410
A synthetic strategy to provide two late-stage intermediates for the synthesis of diverse analogues of ROMK inhibitors for the treatment of hypertension and heart failure is described. Key transfor...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66dd86164e2d822771fedeea6a696007
https://doi.org/10.1021/acs.oprd.0c00314
https://doi.org/10.1021/acs.oprd.0c00314
Autor:
John A. Morrow, Robert Mazzola, Cristian Salinas, Eric D. Hostetler, Stefania Risso, Fiona Thomson, Tjerk Bueters, Nicholas B. Hastings, Jenny Wai, Sony Agrawal, Liza Gantert, Brian C. Magliaro, Paul McQuade, Zhizhen Zeng, Marie A. Holahan, David Hesk, Melissa Egbertson, Jeffrey W. Schubert, Ling Tong, Robert Gomez, Jongrock Kong, Aniket Joshi, Frederick J. Monsma, David M. Tellers, Kristen L.G. Jones, Jason M. Uslaner, Jing Liao, Patricia Miller, Michelle Smith, Oleg Selyutin, Kerry Riffel, Xiaolei Gao, Scott T. Harrison, Zhaoyang Meng, James Mulhearn, Michael Man-Chu Lo, Wenping Li, Michael T. Rudd, Barbara Hanney, Mona Purcell, Jianming Bao, Hyking Haley
Publikováno v:
Journal of Medicinal Chemistry. 63:2411-2425
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::949c4dbede58ed2de44d27f608635d36
https://doi.org/10.1021/acs.jmedchem.9b01406
https://doi.org/10.1021/acs.jmedchem.9b01406
Autor:
Shaoguang Zhang, Dane Clausen, Feng Peng, Yanguang Bai, Jia-Xuan Yan, Nicholas R. Deprez, Jongrock Kong
Publikováno v:
Organic letters. 23(22)
A method for the selective electrochemical aminoxyl-mediated Shono-type oxidation of pyrrolidines to pyrrolidinones is described. These transformations show the high selectivity and functional group compatibility. This chemistry also demonstrates the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52ea54a79bcfa0621b27893a3dc6a76
https://pubmed.ncbi.nlm.nih.gov/34730984
https://pubmed.ncbi.nlm.nih.gov/34730984
Autor:
Jongrock Kong, Matthieu Jouffroy
Publikováno v:
Chemistry - A European Journal. 25:2217-2221
Nucleophilic radical additions at innately electrophilic C(sp2 ) centers are perfectly suited for the direct functionalization of heterocycles. Using bench stable and commercially available alkyl oxamate and oxamic acid derivatives in combination wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de0ab74a0e3a3ed2bb80ee2ea22c3d8
https://doi.org/10.1002/chem.201806159
https://doi.org/10.1002/chem.201806159
Autor:
Jessica A. Hurtak, Steven M. Silverman, Kevin M. Maloney, Patrick S. Fier, Jonathan Vroom, Neil A. Strotman, Mark A. Huffman, Hao Yang, Peter E. Maligres, Tamas Benkovics, Anders M. Knight, Grant S. Murphy, Weilan Pan, Artis Klapars, Jongrock Kong, William J. Morris, John A. McIntosh, Tetsuji Itoh, Hsing-I Ho, Anna Fryszkowska, Deeptak Verma
Publikováno v:
ACS Central Science
ACS Central Science, Vol 7, Iss 12, Pp 1980-1985 (2021)
ACS Central Science, Vol 7, Iss 12, Pp 1980-1985 (2021)
Molnupiravir (MK-4482) is an investigational antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand and urgency for this compound, it was critical to develop a short and sustainable synthesis from sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1790b1ff7f7b99eecc84cb5953e1b588
https://pubmed.ncbi.nlm.nih.gov/34963891
https://pubmed.ncbi.nlm.nih.gov/34963891
Publikováno v:
Organic letters. 23(6)
A practical approach toward the synthesis of 2-arylazoles via direct arylation is described. The transformation relies on a Pd/Cu cocatalyst system that operates with low catalyst loadings. The reaction conditions were found to be tolerant of a wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77dfcece5b2fff9da77c6f49693760bd
https://pubmed.ncbi.nlm.nih.gov/33667104
https://pubmed.ncbi.nlm.nih.gov/33667104