The blood clotting Factor XIIIa forms unique complexes with amyloid-beta (A) and colocalizes with deposited A in cerebral amyloid angiopathy

Autor: de Jager, M., Boot, M. V., Bol, J. G. J. M., Breve, J. J. P., Jongenelen, C. A. M., Drukarch, B., Wilhelmus, M. M. M.

Publikováno v: de Jager, M, Boot, M V, Bol, J G J M, Breve, J J P, Jongenelen, C A M, Drukarch, B & Wilhelmus, M M M 2016, ' The blood clotting Factor XIIIa forms unique complexes with amyloid-beta (A) and colocalizes with deposited A in cerebral amyloid angiopathy ', Neuropathology and Applied Neurobiology, vol. 42, no. 3, pp. 255-272 . https://doi.org/10.1111/nan.12244
Neuropathology and Applied Neurobiology, 42(3), 255-272. Wiley-Blackwell

AimsCerebral amyloid angiopathy (CAA) is a key pathological hallmark of Alzheimer's disease (AD) characterized by accumulation of amyloid‐beta (Aβ) protein in blood vessel walls. CAA impairs vessel functioning, affects blood brain barrier integrit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a73b0ec5aa940a2ec57090439a517ff4
https://research.vumc.nl/en/publications/4cb35422-d047-4fbf-a563-103174ebbf25

NAD(P)H:quinone oxidoreductase (NQO1) protects astroglial cells against L-dopa toxicity

Autor: Drukarch, B, Jongenelen, C A, van Muiswinkel, F L

Publikováno v: Advances in Experimental Medicine and Biology, 500, 237-40. Springer New York
Drukarch, B, Jongenelen, C A & van Muiswinkel, F L 2001, ' NAD(P)H:quinone oxidoreductase (NQO1) protects astroglial cells against L-dopa toxicity ', Advances in Experimental Medicine and Biology, vol. 500, pp. 237-40 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c39f64575a1f32ed6aace09e03b989ec
https://research.vumc.nl/en/publications/77e28565-7107-445d-91f8-67cd1d3e4fcd

Astrocyte-mediated enhancement of neuronal survival is abolished by glutathione deficiency

Autor: Drukarch, B, Schepens, E, Jongenelen, C A, Stoof, J C, Langeveld, C H

Publikováno v: Brain Research, 770(1-2), 123-30. Elsevier
Drukarch, B, Schepens, E, Jongenelen, C A, Stoof, J C & Langeveld, C H 1997, ' Astrocyte-mediated enhancement of neuronal survival is abolished by glutathione deficiency ', Brain Research, vol. 770, no. 1-2, pp. 123-30 .

Astrocytes promote the survival of neurons. Conditions characterized by loss of neurons, such as aging and aging-related neurodegenerative disorders, are accompanied by both disturbances in astrocyte-neuron interactions and signs of oxidative damage.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3158ab1b42cc6da2556eecd92916ceab
https://research.vumc.nl/en/publications/a11c360e-1e97-4680-87be-b939e03e5d61

Glutathione is involved in the granular storage of dopamine in rat PC 12 pheochromocytoma cells:implications for the pathogenesis of Parkinson's disease

Autor: Drukarch, B, Jongenelen, C A, Schepens, E, Langeveld, C H, Stoof, J C

Publikováno v: Drukarch, B, Jongenelen, C A, Schepens, E, Langeveld, C H & Stoof, J C 1996, ' Glutathione is involved in the granular storage of dopamine in rat PC 12 pheochromocytoma cells : implications for the pathogenesis of Parkinson's disease ', Journal of Neuroscience, vol. 16, no. 19, pp. 6038-45 .

Parkinson's disease (PD) is characterized by degeneration of dopamine (DA)-containing nigro-striatal neurons. Loss of the antioxidant glutathione (GSH) has been implicated in the pathogenesis of PD. Previously, we showed that the oxidant hydrogen per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10172::1234420f6f1ba4aeaf18d274b7f90956
https://research.vumc.nl/en/publications/597cd6b2-8450-4af9-bd31-92de341a8c13

Effects of chronic activation of dopamine D-2 receptors in cultures of rat fetal dopaminergic neurons:indications for alterations in functional activity

Autor: Van Muiswinkel, F L, Jongenelen, C A, Schepens, H T, Stoof, J C, Drukarch, B

Publikováno v: Van Muiswinkel, F L, Jongenelen, C A, Schepens, H T, Stoof, J C & Drukarch, B 1995, ' Effects of chronic activation of dopamine D-2 receptors in cultures of rat fetal dopaminergic neurons : indications for alterations in functional activity ', DEVELOPMENTAL BRAIN RESEARCH, vol. 85, no. 1, pp. 128-36 .

In Parkinsonian patients, previously subjected to neuronal grafting therapy, the survival and functional status of dopaminergic grafts might be impaired by the concurrent pharmacotherapy with L-DOPA and/or dopamine (DA) D-2 receptor agonists. To test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10172::69234ed3b062d2b454b1eaaac6b8e943
https://research.vumc.nl/en/publications/a824b133-c4ff-4b25-9a02-337632ee4a0e