Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jongdoo Kim"'
p53-p21 cooperation for H2O2-induced apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0e4b09a4bcfc21387851a9c27776c3
https://doi.org/10.1158/0008-5472.22412529
https://doi.org/10.1158/0008-5472.22412529
The tumor suppressor p53 binds prosurvival Bcl-2 family proteins such as Bcl-w and Bcl-XL to liberate Bax, which in turn exerts proapoptotic or anti-invasive functions depending on stress context. On the basis of our previous finding that p53 interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef52b44e4dc7da5d09f8b0e334aae1c
https://doi.org/10.1158/0008-5472.c.6508458
https://doi.org/10.1158/0008-5472.c.6508458
Publikováno v:
Biochemical and Biophysical Research Communications. 543:23-28
Downregulation of the p53 tumor suppressor in cancers is frequently accompanied by the upregulation of Wip1 (a phosphatase) and Mdm2 (an E3 ubiquitin ligase). Mdm2 binds and ubiquitinates p53, promoting its degradation by the proteasome. As the p53/M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d812af7c1434980b69a42c52ce9519c
https://doi.org/10.1016/j.bbrc.2021.01.074
https://doi.org/10.1016/j.bbrc.2021.01.074
Publikováno v:
Oncology Letters
Our previous study revealed that the tumor suppressor/transcription factor p53 directly binds to its transcriptional target, p21, and that the p53/p21 complex binds to zinc finger protein SNAI2 (Slug), a tumor promoter/transcription factor; thereby p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1661fa67f36e7b403f4d2cb9b94dc3
http://europepmc.org/articles/PMC8323001
http://europepmc.org/articles/PMC8323001
Autor:
Jihyun, Lee, Jongdoo, Kim, Eun Mi, Kim, Ukjin, Kim, A-Ram, Kang, Jong Kuk, Park, Hong-Duck, Um
Publikováno v:
Biochemical and biophysical research communications. 543
Downregulation of the p53 tumor suppressor in cancers is frequently accompanied by the upregulation of Wip1 (a phosphatase) and Mdm2 (an E3 ubiquitin ligase). Mdm2 binds and ubiquitinates p53, promoting its degradation by the proteasome. As the p53/M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e34c2b102ac00234e489e7699b03d6a
https://pubmed.ncbi.nlm.nih.gov/33503543
https://pubmed.ncbi.nlm.nih.gov/33503543
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 95:697-707
The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new treatments for human diseases (drug repositioning). Drug repositioning refers to the development of existing drugs for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04252568e8d8a38744d7d884f53eea9e
https://doi.org/10.1139/cjpp-2016-0519
https://doi.org/10.1139/cjpp-2016-0519
Autor:
Jong Kuk Park, Wan Gi Hong, Hong-Duck Um, Chan-Hun Jung, Eun Mi Kim, Jongdoo Kim, Sang-Gu Hwang, Jeong Hyun Cho, Jae Yeon Choi
Publikováno v:
International Journal of Oncology
We previously reported that podophyllotoxin acetate (PA) radiosensitizes NCI-H460 cells. Here, we confirmed that PA treatment also induces cell death among two other non-small cell lung cancer (NSCLC) cell lines: NCI-H1299 and A549 cells (IC50 values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c2692fb994bbb98c3dc600ed939f3a
https://doi.org/10.3892/ijo.2015.3123
https://doi.org/10.3892/ijo.2015.3123
Autor:
Jongdoo Kim, Jong Kuk Park, Wun-Jae Kim, Hong-Duck Um, Chan-Hun Jung, Sung-Kwon Moon, Sang-Gu Hwang
Publikováno v:
Cancer Letters. 335:270-277
Mdm2 is an oncoprotein that induces the degradation of the tumor suppressor, p53. Here, we show that Mdm2 increases the mRNA levels of Slug by binding to and stabilizing the Slug mRNA. While this effect of Mdm2 was observed in both p53-null and p53-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f268353ab7ec1c07f7ccf0460a3e92
https://doi.org/10.1016/j.canlet.2013.02.035
https://doi.org/10.1016/j.canlet.2013.02.035
Autor:
Jiwoo Chung, Hyejin Kang, Jongdoo Kim, Wei Zhou, Sae-Kwang Ku, Jong-Sup Bae, Sang Chan Kim, MinKyun Na
Publikováno v:
Chemico-biological interactions. 261
Sepsis is a systemic inflammatory condition resulting from bacterial infections. It is associated with high mortality rates, and its therapeutic options are limited. Transforming growth factor β induced protein (TGFBIp) is an extracellular matrix pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9228f739d637c22c91aa16364db1cae0
https://pubmed.ncbi.nlm.nih.gov/27887929
https://pubmed.ncbi.nlm.nih.gov/27887929
Publikováno v:
Archives of pharmacal research. 40(2)
Beyond its role in the activation of protein C, the endothelial cell protein C receptor (EPCR) plays an important role in the cytoprotective pathway. EPCR can be shed from the cell surface, which is mediated by tumor necrosis factor-α converting enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc1c23c05591f196e3025cc45746dc0
https://pubmed.ncbi.nlm.nih.gov/27909955
https://pubmed.ncbi.nlm.nih.gov/27909955