Zobrazeno 1 - 10
of 675
pro vyhledávání: '"Jong-Il Kim"'
Autor:
Sunwoo Chung, June-Hyun Jeong, Jong-Chan Park, Jong Won Han, Yeajina Lee, Jong-Il Kim, Inhee Mook-Jung
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 9, Pp 1936-1951 (2024)
Abstract Abnormal glial activation promotes neurodegeneration in Alzheimer’s disease (AD), the most common cause of dementia. Stimulation of the cGAS-STING pathway induces microglial dysfunction and sterile inflammation, which exacerbates AD. We sh
Externí odkaz:
https://doaj.org/article/b28305d6d7d941f792c61524d2b350f9
Autor:
Young Jun Park, Sungji Moon, Jaeyong Choi, Juhyun Kim, Hyun-Jin Kim, Ho-Young Son, Sun-Wha Im, Jong-Il Kim
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background and purpose Genome-wide association studies (GWAS) of metabolic syndrome (MetS) have predominantly focused on non-Asian populations, with limited representation from East Asian cohorts. Moreover, previous GWAS analyses have primar
Externí odkaz:
https://doaj.org/article/6070348fc14946ec8421b17591cba8a9
Autor:
Jong‐Chan Park, Jong Won Han, Woochan Lee, Jieun Kim, Sang‐Eun Lee, Dongjoon Lee, Hayoung Choi, Jihui Han, You Jung Kang, Yen N. Diep, Hansang Cho, Rian Kang, Won Jong Yu, Jean Lee, Murim Choi, Sun‐Wha Im, Jong‐Il Kim, Inhee Mook‐Jung
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract Microglia play a crucial role in synaptic elimination by engulfing dystrophic neurons via triggering receptors expressed on myeloid cells 2 (TREM2). They are also involved in the clearance of beta‐amyloid (Aβ) plaques in Alzheimer's disea
Externí odkaz:
https://doaj.org/article/33ce11e6b3b945c8827aada3609a7485
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 55, Iss , Pp 101021- (2024)
Cancer of unknown primary (CUP) is a rare type of metastatic cancer in which the origin of the tumor is unknown. Since the treatment strategy for patients with metastatic tumors depends on knowing the primary site, accurate identification of the orig
Externí odkaz:
https://doaj.org/article/c0ef70f7bf334e0ea7cce67d79b2617a
Autor:
Yeajina Lee, Tamrin Chowdhury, Sojin Kim, Hyeon Jong Yu, Kyung-Min Kim, Ho Kang, Min-Sung Kim, Jin Wook Kim, Yong-Hwy Kim, So Young Ji, Kihwan Hwang, Jung Ho Han, Jinha Hwang, Seong-Keun Yoo, Kyu Sang Lee, Gheeyoung Choe, Jae-Kyung Won, Sung-Hye Park, Yong Kyu Lee, Joo Heon Shin, Chul-Kee Park, Chae-Yong Kim, Jong-Il Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 4, Pp 975-986 (2024)
Abstract We explored the genomic events underlying central neurocytoma (CN), a rare neoplasm of the central nervous system, via multiomics approaches, including whole-exome sequencing, bulk and single-nuclei RNA sequencing, and methylation sequencing
Externí odkaz:
https://doaj.org/article/d44946f031d84580b05d28f862c8ade6
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Glaucoma, particularly primary open-angle glaucoma (POAG), poses a significant global health concern. Distinguished by intraocular pressure (IOP), POAG encompasses high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). Apolipoprotein
Externí odkaz:
https://doaj.org/article/b3f040f080914245a453d4b81485ee92
Autor:
Hae Rim Jung, Jeonghwan Lee, Seung-Pyo Hong, Nayeon Shin, Ara Cho, Dong-Jin Shin, Jin Woo Choi, Jong-Il Kim, Jung Pyo Lee, Sung-Yup Cho
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 2, Pp 355-369 (2024)
Abstract Kidney fibrosis is a major mechanism underlying chronic kidney disease (CKD). N6-methyladenosine (m6A) RNA methylation is associated with organ fibrosis. We investigated m6A profile alterations and the inhibitory effect of RNA methylation in
Externí odkaz:
https://doaj.org/article/34b6126bb26c4cb491e8cafd82dfb565
Autor:
Jaeyong Choi, Seung Mi Lee, Errol R. Norwitz, Ji Hoi Kim, Young Mi Jung, Chan-Wook Park, Jong Kwan Jun, Dakyung Lee, Yongjoon Jin, Sookyung Kim, Bukyoung Cha, Joong Shin Park, Jong-Il Kim
Publikováno v:
HGG Advances, Vol 5, Iss 2, Pp 100276- (2024)
Summary: Expression quantitative trait loci (eQTL) analysis measures the contribution of genetic variation in gene expression on complex traits. Although this methodology has been used to examine gene regulation in numerous human tissues, eQTL resear
Externí odkaz:
https://doaj.org/article/5537b659b4d941c7a3aab6ef70d4bb24
Autor:
Jaeryuk Kim, Seung-Pyo Hong, Seyoon Lee, Woochan Lee, Dakyung Lee, Rokhyun Kim, Young Jun Park, Sungji Moon, Kyunghyuk Park, Bukyoung Cha, Jong-Il Kim
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-15 (2023)
Abstract Background Fragmentomics, the investigation of fragmentation patterns of cell-free DNA (cfDNA), has emerged as a promising strategy for the early detection of multiple cancers in the field of liquid biopsy. However, the clinical application
Externí odkaz:
https://doaj.org/article/8b998c061fa34b3d9c74505a98d53d26
Autor:
Woochan Lee, Seyoon Lee, Jung-Ki Yoon, Dakyung Lee, Yuri Kim, Yeon Bi Han, Rokhyun Kim, Sungji Moon, Young Jun Park, Kyunghyuk Park, Bukyoung Cha, Jaeyong Choi, Juhyun Kim, Na-young Ha, Kwhanmien Kim, Sukki Cho, Nam-Hyuk Cho, Tushar J. Desai, Jin-Haeng Chung, Joo-Hyeon Lee, Jong-Il Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 8, Pp 1831-1842 (2023)
Abstract We present an in-depth single-cell atlas of in vitro multiculture systems on human primary airway epithelium derived from normal and diseased lungs of 27 individual donors. Our large-scale single-cell profiling identified new cell states and
Externí odkaz:
https://doaj.org/article/a5124a68abf946d1a4a08b7e81df62ac