Výsledky vyhledávání - "Jong-Ding Lay"

Akademický článek

Prevalence of Obesity and Its Association with Cardiovascular Disease Risk Factors in Adolescent Girls from a College in Central Taiwan

Autor: John Jenn-Yenn Lu, Donald Dah-Shyong Jiang, Shieu-Ming Chou, Chang-Bor Hor, Jong-Ding Lay, Hsiang-Ling Wang

Publikováno v: Kaohsiung Journal of Medical Sciences, Vol 24, Iss 3, Pp 144-151 (2008)

Although obesity is associated with important hemodynamic disturbances, little data exists on population-wide cardiovascular risk factors in obese adolescent girls in Taiwan. This study measured the prevalence of overweight/obesity and related cardio

Externí odkaz: https://doaj.org/article/1956f88209364d1ea83f62ed317cd677

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Data from Sulfasalazine Suppresses Drug Resistance and Invasiveness of Lung Adenocarcinoma Cells Expressing AXL

Autor: Shuang-En Chuang, Ih-Jen Su, Ann-Lii Cheng, Gi-Ming Lai, Yi-Pin Lai, Ching-Hang Liu, Chung-Yi Pao, Ya-Yu Yang, Jhy-Shrian Huang, Chih-Chen Hong, Jong-Ding Lay

Metastasis and drug resistance are the major causes of mortality in patients with non–small cell lung cancer (NSCLC). Several receptor tyrosine kinases (RTKs), including AXL, are involved in the progression of NSCLC. The AXL/MER/SKY subfamily is in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c40190aeab6c7f68a01bcff05840fb
https://doi.org/10.1158/0008-5472.c.6495858.v1

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PTBP1-mediated regulation of AXL mRNA stability plays a role in lung tumorigenesis

Autor: Shuang En Chuang, Shih Sheng Jiang, Tsu Hsiang Kuo, Jhy Shrian Huang, Chun Yu Cho, Shih Ying Chung, Li Chun Cheng, Gi Ming Lai, Ya Yu Yang, Yen-Lin Chen, Jong Ding Lay, Shankung Lin

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

AXL is expressed in many types of cancer and promotes cancer cell survival, metastasis and drug resistance. Here, we focus on identifying modulators that regulate AXL at the mRNA level. We have previously observed that the AXL promoter activity is in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f68563d2f2404e621459ae000afe815
https://doi.org/10.1038/s41598-019-53097-2

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Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells

Autor: Jong Ding Lay, Chun Yu Cho, Ann-Lii Cheng, Li-Tzong Chen, Shuang En Chuang, Shine-Gwo Shiah, Jhy Shrian Huang, Shih Ying Chung, Gi Ming Lai, Ya Yu Yang

Publikováno v: RNA. 22:303-315

The AXL receptor tyrosine kinase is frequently overexpressed in cancers and is important in cancer invasion/metastasis and chemoresistance. Here, we demonstrate a regulatory feedback loop between AXL and microRNA (miRNA) at the post-transcriptional l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0085ef4194a8658fa4c8dc906fa1eb
https://doi.org/10.1261/rna.052571.115

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Akademický článek

Epstein-Barr Virus Latent Membrane Protein-1 Mediates Upregulation of Tumor Necrosis Factor-α in EBV-Infected T Cells: Implications for the Pathogenesis of Hemophagocytic Syndrome.

Autor: Jong-Ding Lay, Frederic¹, Shuang-En Chuang, Frederic¹, Rowe, Martin², Ih-Jen Su^3,4 suihjen@nhri.org.tw

Publikováno v: Journal of Biomedical Science. Jan/Feb2003, Vol. 10 Issue 1, p146-155. 10p. 5 Diagrams, 4 Graphs.

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Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

Autor: Shuang En Chuang, Jong Ding Lay, Ming Tseh Lin, Jhy Shrian Huang, Ann-Lii Cheng, Jih-Luh Tang, Chih Chen Hong, Gi Ming Lai

Publikováno v: Cancer Letters. 268:314-324

By using a novel profiling analysis of protein tyrosine kinases differentially expressed in the sensitive and refractory leukemia from the same patients we found that AXL was upregulated in drug-resistant leukemia. Furthermore, AXL could be induced b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed9d2ba3643f76b30247d63aa3faa8b
https://doi.org/10.1016/j.canlet.2008.04.017

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Pathogenesis and mechanism of disease progression from hemophagocytic lymphohistiocytosis to Epstein-Barr virus-associated T-cell lymphoma: Nuclear factor-κB pathway as a potential therapeutic target

Autor: Ih-Jen Su, Huai-Chia Chuang, Wen-Chuan Hsieh, Jong-Ding Lay

Publikováno v: Cancer Science. 98:1281-1287

Epstein-Barr virus (EBV) can infect T lymphocytes and manifests as hemophagocytic lymphohistiocytosis (HLH), a distinct entity of hemophagocytic syndrome (HPS) characterized by fever, hepatosplenomegaly, cytopenia, hypercytokinemia, and systemic macr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6512f44a9623db727f6ef2e8e049b43e
https://doi.org/10.1111/j.1349-7006.2007.00549.x

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Epstein-Barr Virus (EBV) Latent Membrane Protein-1 Down-Regulates Tumor Necrosis Factor-α (TNF-α) Receptor-1 and Confers Resistance to TNF-α-Induced Apoptosis in T Cells

Autor: Wen-Chuan Hsieh, Ih-Jen Su, Shuang-En Chuang, Huai-Chia Chuang, Jong-Ding Lay, Yao Chang

Publikováno v: The American Journal of Pathology. 170:1607-1617

The infection of T cells by Epstein-Barr virus (EBV) may result in hemophagocytic syndrome (HPS) through enhanced cytokine secretion, particularly tumor necrosis factor-α (TNF-α), by EBV latent membrane protein-1 (LMP-1). One bewildering observatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69372852cca5b40ec9fac19dc8380fda
https://doi.org/10.2353/ajpath.2007.061026

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