Aminooxy acetic acid suppresses Th17-mediated psoriasis-like skin inflammation by inhibiting serine metabolism

Autor: Jong Yeong Lee, Ji-Hyun Lee, Hyo Jung Lim, Eonho Kim, Dae-Ki Kim, Jin Kyeong Choi

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Background: Psoriasis is a common chronic inflammatory skin disease characterized by an external red rash that is caused by abnormal proliferation and differentiation of keratinocytes and immune T cells. This study aimed to elucidate the role of amin

Externí odkaz: https://doaj.org/article/7f9e7e0108b345dea606a97c4e4d32df

Abstract 709: AST-301, a pDNA-based therapeutic cancer vaccine encoding HER2 ICD, improves the efficacy of checkpoint blockade therapy in CD34+ humanized gastric cancer mouse model

Autor: Hyo-Hyun Park, Hye-Ran Kim, Jin Kyeong Choi, Jee Hyun Choi, JinHo Kang, Jinback Lim, Hyo Jung Lim, Jong Yeong Lee, Eunkyo Joung, Hun Jung

Publikováno v: Cancer Research. 83:709-709

PD-1/PD-L1 play a crucial role in modulating immune response and promoting self-tolerance through activating apoptosis of antigen-specific T cells and suppressing apoptosis of regulatory T cells. Although immunotherapy to block this may provide a gre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::725c32e29e58cbe1a831ee374c75af59
https://doi.org/10.1158/1538-7445.am2023-709

IL-35 suppresses pathogenic T cell response in atopic dermatitis by inhibiting PSAT1 activation

Autor: Hyo Jung Lim, Jong Yeong Lee, Jin kyeong Choi

Publikováno v: The Journal of Immunology. 208:56.08-56.08

Interleukin 35 (IL-35) is a member of the IL-12 family and immune-suppressive cytokine and a critical regulator of immunity during autoimmune and infectious diseases. However, it is unclear whether IL-35 can control skin inflammation by regulating th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24ffda53249b94b29861fcefa8d1c8f1
https://doi.org/10.4049/jimmunol.208.supp.56.08

A New Approach to Determine the Optimal Number of Clusters Based on the Gap Statistic

Autor: Yeongin Joo, Jong-Yeong Lee, Jaekyung Yang, Myoungjin Choi

Publikováno v: Lecture Notes in Computer Science
2nd International Conference on Machine Learning for Networking (MLN)
2nd International Conference on Machine Learning for Networking (MLN), Dec 2019, Paris, France. pp.227-239, ⟨10.1007/978-3-030-45778-5_15⟩
Machine Learning for Networking ISBN: 9783030457778
MLN

International audience; Data clustering is one of the most important unsupervised classification method. It aims at organizing objects into groups (or clusters), in such a way that members in the same cluster are similar in some way and members belon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f198a934849287d22b28a0aa824e82e7
https://hal.inria.fr/hal-03266454/file/487577_1_En_15_Chapter.pdf

Anti-inflammatory effects of ursolic acid-3-acetate on human synovial fibroblasts and a murine model of rheumatoid arthritis

Autor: Seung Woong Lee, Taeg Kyu Kwon, Sang-Hyun Kim, Pil-Hoon Park, Na-Hee Jeong, Soyoung Lee, Jin Kyeong Choi, Sang-Rae Lee, Hyukjae Choi, Yeong Su Ha, Jeongsoo Yoo, Jong Yeong Lee, Tae-Yong Shin, Mun-Chual Rho, Byung-Heon Lee

Publikováno v: International Immunopharmacology. 49:118-125

Ursolic acid (UA), a pentacyclic triterpenoid, is a common natural substance known to be effective in the treatment of inflammation, oxidative stress, and ulcers in arthritis. This study examined the effects of ursolic acid-3-acetate (UAA), a derivat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeec20c52a27cc2ee18ad58f2dbc0f4e
https://doi.org/10.1016/j.intimp.2017.05.028