Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Jong Kil Lee"'
Autor:
Min Sung Gee, Eunji Kwon, Myeong-Hoon Song, Seung Ho Jeon, Namkwon Kim, Jong Kil Lee, Taeyoung Koo
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/22824669e7014f37b41a9b796665dc30
Autor:
Namkwon Kim, In Gyoung Ju, Seung Ho Jeon, Yeongae Lee, Min-Ji Jung, Min Sung Gee, Jae Seok Cho, Kyung-Soo Inn, Lee Ann Garrett-Sinha, Myung Sook Oh, Jong Kil Lee
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Background The gut microbiota has recently attracted attention as a pathogenic factor in Alzheimer’s disease (AD). Microfold (M) cells, which play a crucial role in the gut immune response against external antigens, are also exploited for
Externí odkaz:
https://doaj.org/article/05472f880fb74e1aaeea256535d8861f
Autor:
Ahmed H. E. Hassan, Hyeon Jeong Kim, Min Sung Gee, Jong-Hyun Park, Hye Rim Jeon, Cheol Jung Lee, Yeonwoo Choi, Suyeon Moon, Danbi Lee, Jong Kil Lee, Ki Duk Park, Yong Sup Lee
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 768-780 (2022)
Multifunctional molecules might offer better treatment of complex multifactorial neurological diseases. Monoaminergic pathways dysregulation and neuroinflammation are common convergence points in diverse neurodegenerative and neuropsychiatric disorde
Externí odkaz:
https://doaj.org/article/3f762b2947fa45439b6857349ca801c1
Autor:
Ahmed H. E. Hassan, Hyeon Jeong Kim, Keontae Park, Yeonwoo Choi, Suyeon Moon, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Min Sung Gee, Danbi Lee, Jong-Hyun Park, Jong Kil Lee, Jong Hoon Ryu, Ki Duk Park, Yong Sup Lee
Publikováno v:
Antioxidants, Vol 12, Iss 5, p 1033 (2023)
Oxidative catabolism of monoamine neurotransmitters by monoamine oxidases (MAOs) produces reactive oxygen species (ROS), which contributes to neuronal cells’ death and also lowers monoamine neurotransmitter levels. In addition, acetylcholinesterase
Externí odkaz:
https://doaj.org/article/51c4602921694db4a6786dc3cf8aa3d3
Autor:
Min Sung Gee, Seung Hwan Son, Seung Ho Jeon, Jimin Do, Namkwon Kim, Yeon-Joo Ju, Soo Jin Lee, Eun Kyoung Chung, Kyung-Soo Inn, Nam-Jung Kim, Jong Kil Lee
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-18 (2020)
Abstract Background Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal cell loss, and cognitive impairment are pathological presentations of Alzheimer’s disease (AD). Therefore, resolution of neuroinflammation and inhibit
Externí odkaz:
https://doaj.org/article/b1ea94564d774370a4ff5064f7f2dfe3
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 111, Iss , Pp 1359-1366 (2019)
Abnormal inflammatory response in the central nervous system plays a critical role in various neurological disorders such as Parkinson’s disease, Alzheimer’s disease and Huntington’s disease. Therefore, modulation of abnormal neuroinflammation
Externí odkaz:
https://doaj.org/article/76f06de8322448c4b6fbcaa6dc830a59
Autor:
Namkwon Kim, Jimin Do, Jae-sung Bae, Hee Kyung Jin, Jong-Ho Kim, Kyung-Soo Inn, Myung Sook Oh, Jong Kil Lee
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 2, Pp 195-201 (2018)
Inflammatory processes in the central nervous system are feature among biological reactions to harmful stimuli such as pathogens and damaged cells. In resting conditions, microglia are involved in immune surveillance and brain homeostasis. However, t
Externí odkaz:
https://doaj.org/article/9c697287c7294d399d1cad0ffabb82b7
Autor:
Ga Yeong Kim, Chae Won Song, Yo-Sep Yang, Na-Rae Lee, Hyung-Seok Yoo, Seung Hwan Son, Soo Jin Lee, Jong Seon Park, Jong Kil Lee, Kyung-Soo Inn, Nam-Jung Kim
Publikováno v:
Molecules, Vol 26, Iss 9, p 2525 (2021)
A series of PROTACs (PROteolysis-TArgeting Chimeras) consisting of bicalutamide analogs and thalidomides were designed, synthesized, and biologically evaluated as novel androgen receptor (AR) degraders. In particular, we found that PROTAC compound 13
Externí odkaz:
https://doaj.org/article/32dd86b792cc47b8baed18485d0d87de
Publikováno v:
Brain Sciences, Vol 10, Iss 11, p 793 (2020)
Mild cognitive impairment (MCI) generally refers to impairment in cognition above that which accompanies the normal age-related cognitive decline and has attracted attention in recent years. Trans-cinnamaldehyde (TCA), which is isolated from cinnamon
Externí odkaz:
https://doaj.org/article/3dafa259abb648689b22f08bcef03a69
Autor:
Na-Rae Lee, Junsu Ban, Noh-Jin Lee, Chae-Min Yi, Ji-Yoon Choi, Hyunbin Kim, Jong Kil Lee, Jihye Seong, Nam-Hyuk Cho, Jae U. Jung, Kyung-Soo Inn
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Autophagy has been implicated in innate immune responses against various intracellular pathogens. Recent studies have reported that autophagy can be triggered by pathogen recognizing sensors, including Toll-like receptors and cyclic guanosine monopho
Externí odkaz:
https://doaj.org/article/1bfa347b8c064074aca0e1b2f7f0ecd5