Výsledky vyhledávání - "Jong Chan Son"

Akademický článek

The effect of dexmedetomidine on the adjuvant propofol requirement and intraoperative hemodynamics during remifentanil-based anesthesia

Autor: Woon-Seok Kang, Sung-Yun Kim, Jong-Chan Son, Ju-Deok Kim, Hasmizy Bin Muhammad, Seong-Hyop Kim, Tae-Gyoon Yoon, Tae-Yop Kim

Publikováno v: Korean Journal of Anesthesiology, Vol 62, Iss 2, Pp 113-118 (2012)

BackgroundThe effects of dexmedetomidine on the propofol-sparing effect and intraoperative hemodynamics during remifentanil-based propofol-supplemented anesthesia have not been well investigated.MethodsTwenty patients undergoing breast surgery were r

Externí odkaz: https://doaj.org/article/1ed40bba59834b85818653d6f061ae80

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The design of potential antidiabetic drugs: experimental investigation of a number of beta-D-glucose analogue inhibitors of glycogen phosphorylase

Autor: Maria Kontou, H. S. Tsitoura, Louise N. Johnson, K.R. Acharya, C. J. F. Bichard, K.A. Watson, Spyros E. Zographos, Demetres D. Leonidas, E. P. Mitchell, George W. J. Fleet, Nikos G. Oikonomakos, Jong Chan Son

alpha-D-glucose is a weak inhibitor (Ki = 1.7 mM) of glycogen phosphorylase (GP) and acts as physiological regulator of hepatic glycogen metabolism; it binds to GP at the catalytic site and stabilizes the inactive T state of the enzyme promoting the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b4e8773c0f89d62eb8d10ee6f38a0b
https://doi.org/10.1007/bf03188920

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POLYHYDROXYLATED PYRROLIDINES FROM SUGAR LACTONES - SYNTHESIS OF 1,4-DIDEOXY-1,4-IMINO-D-GLUCITOL FROM D-GALACTONOLACTONE AND SYNTHESES OF 1,4-DIDEOXY-1,4-IMINO-D-ALLITOL, 1,4-DIDEOXY-1,4-IMINO-D-RIBITOL, AND (2S,3R,4S)-3,4-DIHYDROXYPROLINE FROM D-GULONOLACTONE

Autor: George W. J. Fleet, Jong Chan Son

The use of readily available sugar lactones in the synthesis of polyhydroxylated pyrrolidines is illustrated by the preparation of the glucosidase inhibitor 1,4-dideoxy-1, 4-imino-D-glucitol from D-galactonolactone and by the conversion of D-gulonola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4761ea4f81d1584ff64257a674d769
https://doi.org/10.1016/s0040-4020(01)81716-6

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The effect of dexmedetomidine on the adjuvant propofol requirement and intraoperative hemodynamics during remifentanil-based anesthesia

Autor: Tae-Gyoon Yoon, Jong-Chan Son, Seong-Hyop Kim, Tae-Yop Kim, Ju Deok Kim, Sung-Yun Kim, Hasmizy Bin Muhammad, Woon-Seok Kang

Publikováno v: Korean Journal of Anesthesiology, Vol 62, Iss 2, Pp 113-118 (2012)
Korean Journal of Anesthesiology

Background: The effects of dexmedetomidine on the propofol-sparing effect and intraoperative hemodynamics during remifentanil-based propofol-supplemented anesthesia have not been well investigated. Methods: Twenty patients undergoing breast surgery w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7462eecce22553ef59e6af0d9d7e922
http://ekja.org/upload/pdf/kjae-62-113.pdf

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N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Autor: Doris Graupe, Yun-A Im, Jong Chan Son, Romas Geleziunas, Eun Jung Cho, Eric B. Lansdon, Amber Paul, Hongyan Guo, Gong-Xin He, Lianhong Xu, Jaclyn Hayes, James M. Chen, Choung U. Kim, Michael L. Mitchell, Jianhong Wang, Michael Wang, Gerry Rhodes

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:1589-1592

A series of N1-alkyl pyrimidinediones were designed, synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Our efforts identified compound 10b, which represents the lead compound in this series with pharmacokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580eae4286c53b40bb72e6ab7e081863
https://doi.org/10.1016/j.bmcl.2010.01.085

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In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20)

Autor: Dominique Schols, Mohammad-Ali Jenabian, Jong Chan Son, Yven Van Herrewege, Guido Vanham, Héla Saïdi, Charlotte Charpentier, Jan Balzarini, Laurent Bélec

Publikováno v: Journal of Antimicrobial Chemotherapy. 64:1192-1195

OBJECTIVES: To block the different mechanisms of HIV mucosal transmission, it is likely that use of several microbicide molecules will lead to the best protection against HIV transmission. Indeed, the combination of microbicides with complementary me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d36710d4588cef132ab055be64f0a9e
https://doi.org/10.1093/jac/dkp380

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N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Autor: James M. Chen, Ill Young Lee, Eric B. Lansdon, Amber Paul, Jaclyn Hayes, Jianhong Wang, Choung U. Kim, Hae Soo Kim, Romas Geleziunas, Michael L. Mitchell, Hongyan Guo, Lianhong Xu, Chong-Kyo Lee, Jong Chan Son, Gene Eisenberg, Michael Wang

Publikováno v: Bioorganicmedicinal chemistry letters. 20(5)

A series of N1-heterocyclic pyrimidinediones were extensively evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Inhibitor 1 is active against NNRTI-resistant viruses including RT mutant K103N. The co-crystal structure of in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab599674aa00296bfce699210db35b15
https://pubmed.ncbi.nlm.nih.gov/20137928

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