Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jones Terence R"'
Autor:
Mishima, Kazuhiko, Mazar, Andrew P., Gown, Allen, Skelly, Marilyn, Ji, Xiang-Dong, Wang, Xu-Dong, Jones, Terence R., Cavenee, Webster K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2000 Jul . 97(15), 8484-8489.
Externí odkaz:
https://www.jstor.org/stable/122927
Autor:
Dzuy T. Nguyen, Eleanor F. Howland, S. M. Herrmann, C. A. Morse, Russell J. Bacquet, Jones Terence R, Ward W. Smith, Charlotte A. Bartlett, Stephanie Webber, K. M. Welsh, Cheryl Ann Janson, Kathardekar, M. R. Reddy, Carol L. J. Booth, H. Mazdiyasni, Lewis Kk, J. White, A. Johnston, J. Deal, Stephen E. Webber, David A. Matthews, Robert William Ward, Varney
Publikováno v:
Journal of Medicinal Chemistry. 40:677-683
Six new diphenyl sulfoxide and five new diphenyl sulfones were designed, synthesized, and tested for their inhibition of human and Escherichia coli thymidylate synthase (TS) and of the growth of cells in tissue culture. The best sulfoxide inhibitor o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b00058c01b30433c8d4b3576dc6989
https://doi.org/10.1021/jm960613f
https://doi.org/10.1021/jm960613f
Autor:
Jesus Ernesto Villafranca, Carol L. J. Booth, Charlotte A. Bartlett, Stephanie Webber, Cindy L. Palmer, C. A. Morse, Varney Michael D, Ellen W. Moomaw, Jones Terence R, S. M. Herrmann, Krzysztof Appelt, Kathleen K. Lewis, Katharine M. Welsh, Robert William Ward, Cheryl Ann Janson, Russell J. Bacquet, Eleanor F. Howland, Ward W. Smith, Stephen E. Webber, Vinit Kathardekar, David A. Matthews, Jennifer White, Marzoni Gifford P
Publikováno v:
Journal of Medicinal Chemistry. 39:904-917
To develop novel lipophilic thymidylate synthase (TS) inhibitors, the X-ray structure of Escherichia coli TS in ternary complex with FdUMP and the inhibitor 10-propargyl-5,8-dideazafolic acid (CB3717) was used as a basis for structure-based design. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f33e515142229b5c112750e718425e0
https://doi.org/10.1021/jm9502652
https://doi.org/10.1021/jm9502652
Autor:
K. K. Lewis, Varney Michael D, V. Kathardekar, Stephen E. Webber, W. W. Smith, J. Deal, K. M. Welsh, Eleanor F. Howland, A L A L Et Et, Cheryl Ann Janson, S. M. Herrmann, Robert William Ward, M. R. Reddy, Jones Terence R, H. Mazdiyasni, A. Johnston, Nguyen Dzuy Nguyen Dzuy, David A. Matthews, Carol L. J. Booth, R. J. Bacquet, J. M. White, Stephanie Webber
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::201e17e042b9b510146812a0e89ce63a
https://doi.org/10.1002/chin.199724103
https://doi.org/10.1002/chin.199724103
Autor:
Stephan T. Freer, M. Rami Reddy, Jones Terence R, Katherine M. Welsh, Russell J. Bacquet, Dominic Zichi, David A. Matthews
Publikováno v:
Journal of the American Chemical Society. 114:10117-10122
The thermodynamic cycle perturbation approach, in conjunction with molecular dynamics simulations, has been used to calculate relative binding free energies for the closely related inhibitors 10-propargyl-5,8-dideazafolic acid (PDDF) and 10-formyl-5,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fed36ae60d15577708433d1e510ec2c
https://doi.org/10.1021/ja00052a005
https://doi.org/10.1021/ja00052a005
Autor:
Marsham Pr, Alan Hilary Calvert, Thornton Tj, O'Connor Bm, Ann L. Jackman, Leslie Richard Hughes, J. A. M. Bishop, Jones Terence R
Publikováno v:
Journal of Medicinal Chemistry. 33:3067-3071
The synthesis of 2'-fluoro-10-propargyl-5,8-dideazafolic acid and its 2-desamino, 2-desamino-2-hydroxymethyl, and 2-desamino-2-methoxy analogues is described. In general the synthetic route involved the coupling of diethyl N-[2-fluoro-4-(prop-2-ynyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425b61c3d9426619dbb79d44e06d6012
https://doi.org/10.1021/jm00173a025
https://doi.org/10.1021/jm00173a025
Autor:
Alan Hilary Calvert, J. A. M. Bishop, O'Connor Bm, Leslie Richard Hughes, Marsham Pr, Smith Rc, Ann L. Jackman, Jones Terence R, Kenneth David Burrows, J. Oldfield
Publikováno v:
Journal of medicinal chemistry. 33(11)
Modification of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(2-amino-3,4-dihydro-4-oxo-6-quinazolinyl)methyl]-N-prop-2- ynylamino]benzoyl]-L-glutamic acid (1a) has led to the synthesis of quinazoline antifolates bearing alkyl, substituted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fde669dda075cb26f49f597698980b
https://pubmed.ncbi.nlm.nih.gov/2231606
https://pubmed.ncbi.nlm.nih.gov/2231606
Publikováno v:
ChemInform. 21
The synthesis of N3-methyl-10-propargyl-5,8-dideazafolic acid (1b) is described. Ring closure of methyl-5-methylanthranilate with chloroformamidine hydrochloride gave a high yield of pure 2-amino-4-hydroxy-6-methylquinazoline treatment of which with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc53bc6c19620a8accb997cb74d5711
https://doi.org/10.1002/chin.199010209
https://doi.org/10.1002/chin.199010209
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Akademický článek
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