Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jones Philip Stephen"'
Autor:
Marcia Renzetti, Jones Philip Stephen, Ralph Garippa, Glyn Williams, Joseph A. Sergi, Ying Peng, Kevin Richard Guertin, Fiorenza Falcioni, Hilary A. Overton, Lida Qi, Rogely Boyce, Andrée R. Olivier, Karen Wang, Rachel M. Dunsdon, Mathew Taylor, Brian William Dymock, Lina Setti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2895-2898
A novel series of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents have been identified. These compounds show non-selective inhibitory properties against a panel of protein tyrosine phosphatases including PTP1B. Comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a17384433d52272fadaa8c14dd8bbe1
https://doi.org/10.1016/s0960-894x(03)00623-1
https://doi.org/10.1016/s0960-894x(03)00623-1
Publikováno v:
Chemistry - A European Journal. 8:5435-5446
Chemical double-mutant cycles have been used to quantify intermolecular functional-group interactions in H-bonded zipper complexes in chloroform. If the same interaction is measured in zippers of different overall stability, the double-mutant cycles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02da5958d4f51eee087453797cb40bcf
https://doi.org/10.1002/1521-3765(20021202)8:23<5435::aid-chem5435>3.0.co
https://doi.org/10.1002/1521-3765(20021202)8:23<5435::aid-chem5435>3.0.co
Autor:
Stephen J. Kirtland, Amanda G. Fallowfield, Neera Borkakoti, Lauri Price, Jones Philip Stephen, Gillian A. Bottomley, Glyn J. Price, Glyn Williams, Irene Cowan
Publikováno v:
Journal of Biological Chemistry. 271:9579-9586
Interleukin-8 (IL-8) is a dimeric, C-X-C chemokine, produced by a variety of cells and which elicits pro-inflammatory responses from the neutrophil. As a prelude to drug design, we have investigated the interactions between IL-8 and its receptor by p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04f14b98822aba811e9a8b05857d55cc
https://doi.org/10.1074/jbc.271.16.9579
https://doi.org/10.1074/jbc.271.16.9579
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5145fcdda18a66bd485226592aa8f160
https://doi.org/10.1002/chin.199815105
https://doi.org/10.1002/chin.199815105
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59a3ea6d9321a640811e73b76ca0edda
https://doi.org/10.1002/chin.199808204
https://doi.org/10.1002/chin.199808204
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3e51f7f775280ec1a839eb5ccfbb78e
https://doi.org/10.1002/chin.199840296
https://doi.org/10.1002/chin.199840296
Publikováno v:
Synlett. 12:1423-1425
Reaction of lithiated (phenylsulfonyl)methane with enantiomerically pure N-diphenylphosphinylaziridines gives adducts 4, which may be acylated at the sulfone α-position by further lithiation and reaction with non-enolisable acid chlorides, giving ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7ac445f53b0ff2047916070a8d175ec
https://doi.org/10.1055/s-1997-1054
https://doi.org/10.1055/s-1997-1054
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 3, Iss 1, p 39 (2007)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
We have developed a general strategy for the synthesis of 2,5-syn disubstituted pyrrolidines that is based on the multi-faceted reactivity of the sulfone moiety and a 5-endo-trig cyclisation. This methodology was applied to the synthesis of indolizid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd843efd4736c60ad92cac7170bbb16
https://doaj.org/article/0e8974c998f24b1d8020f7d33a5172ae
https://doaj.org/article/0e8974c998f24b1d8020f7d33a5172ae
Autor:
Jones Philip Stephen
Viral diseases were largely untreatable 40 yr ago. Now effective and safe therapies are available. This has led to significant improvements in the quality of life for large numbers of patients. New viral diseases are, however, continuing to emerge an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30b67f95293e04ce125186e1ed3f4821
https://doi.org/10.1385/1-59259-245-7:1
https://doi.org/10.1385/1-59259-245-7:1
Publikováno v:
Chemical communications (Cambridge, England). (14)
Synthetic H-bonded molecular zippers contain no sequence information that can be used to engineer the selective binding interactions characteristic of biopolymers; reversing the sense of the amide bonds in the two binding partners generates a new ort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88db1eeaff9d81eab80e8c991b09b1a6
https://pubmed.ncbi.nlm.nih.gov/12877481
https://pubmed.ncbi.nlm.nih.gov/12877481