Zobrazeno 1 - 10
of 21 252
pro vyhledávání: '"Jones K."'
Autor:
Tina Rönn, Jones K. Ofori, Alexander Perfilyev, Alexander Hamilton, Karolina Pircs, Fabian Eichelmann, Sonia Garcia-Calzon, Alexandros Karagiannopoulos, Hans Stenlund, Anna Wendt, Petr Volkov, Matthias B. Schulze, Hindrik Mulder, Lena Eliasson, Sabrina Ruhrmann, Karl Bacos, Charlotte Ling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Epigenetic dysregulation may influence disease progression. Here we explore whether epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 diabetes (T2D). In islets, 5,584 DNA methylation sites exhibit alterati
Externí odkaz:
https://doaj.org/article/19bed20de77c4fe59cb47f79626a6477
Autor:
Alexandros Karagiannopoulos, Efraim Westholm, Jones K. Ofori, Elaine Cowan, Jonathan L.S. Esguerra, Lena Eliasson
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106555- (2023)
Summary: Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting En
Externí odkaz:
https://doaj.org/article/68be0083631b4762bbc8a922b0b0f138
Autor:
Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K. Ofori, Ludivine Bertonnier-Brouty, Tina Rönn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Åsa Nilsson, Sevda Gheibi, Claire L. Lyons, Jens O. Lagerstedt, Mohammad Barghouth, Jonathan L.S. Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Rashmi B. Prasad, Luis Rodrigo Cataldo, Charlotte Ling
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic islets from approximately 300 individuals. We found 395 different
Externí odkaz:
https://doaj.org/article/1b6d5184407e4059bd119a1db2f0c8ba
Publikováno v:
Opt. Express 32, 23812-23821 (2024)
We construct a phase-conjugate resonator which passively produces stable pulses that alternate between the probe and the conjugate colors. The requisite phase-conjugate mirror inside the resonator is constructed using non-degenerate four-wave mixing
Externí odkaz:
http://arxiv.org/abs/2406.11071
Autor:
Jonathan L.S. Esguerra, Jones K. Ofori, Mototsugu Nagao, Yuki Shuto, Alexandros Karagiannopoulos, Joao Fadista, Hitoshi Sugihara, Leif Groop, Lena Eliasson
Publikováno v:
Molecular Metabolism, Vol 32, Iss , Pp 160-167 (2020)
Objective: A widely recognized metabolic side effect of glucocorticoid (GC) therapy is steroid-induced diabetes mellitus (DM). However, studies on the molecular basis of GC-induced pancreatic beta cell dysfunction in human beta cells are lacking. The
Externí odkaz:
https://doaj.org/article/bb327f4b2515459695089bf377a819f8
Autor:
Hector Attu, Jones K. Adjei
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-8 (2018)
Abstract Background Although malaria is endemic across Ghana, the risk is generally elevated for residents living in and around stagnant water bodies such as dams and irrigated farming projects. What knowledge do these at-risk populations have about
Externí odkaz:
https://doaj.org/article/f21312afa92a44c3aebbc4c4dd50c768
Autor:
Judith K. Stephens, Eric Kyei-Baafour, Emmanuel K. Dickson, Jones K. Ofori, Michael F. Ofori, Mark L. Wilson, Isabella A. Quakyi, Bartholomew D. Akanmori
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-10 (2017)
Abstract Background Women exposed to Plasmodium infection develop antibodies and become semi-immune. This immunity is suppressed during pregnancy making both the pregnant woman and the foetus vulnerable to the adverse effects of malaria, particularly
Externí odkaz:
https://doaj.org/article/cb93951445c54ca897b88b76711f4794
Autor:
Gu Li, Amery D. Wu, Sheila K. Marshall, Ryan J. Watson, Jones K. Adjei, Minjeong Park, Elizabeth M. Saewyc
Publikováno v:
SSM: Population Health, Vol 7, Iss , Pp - (2019)
There is limited research on evaluating nonrandomized population health interventions. We aimed to introduce a new approach for assessing site-level longitudinal effects of population health interventions (SLEPHI) by innovatively applying multiple gr
Externí odkaz:
https://doaj.org/article/d9a681297cd1450aabc4f2ecad99cf51
Publikováno v:
Front. Phys. 11:1242668 (2023)
The structure of the unbound nucleus $^{13}$Be is important to understanding the Borromean, two-neutron halo nucleus $^{14}$Be. The experimental studies conducted over the last four decades are reviewed in the context of the beryllium chain of isotop
Externí odkaz:
http://arxiv.org/abs/2309.10086