Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.

Autor: Nicholas DA; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA., Proctor EA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Agrawal M; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA., Belkina AC; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA; Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA., Van Nostrand SC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Panneerseelan-Bharath L; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA., Jones AR 4th; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA., Raval F; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA., Ip BC; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA., Zhu M; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA., Cacicedo JM; Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA., Habib C; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA., Sainz-Rueda N; Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA., Persky L; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA., Sullivan PG; Department of Neuroscience, Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA., Corkey BE; Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA., Apovian CM; Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA., Kern PA; Department of Medicine, University of Kentucky, Lexington, KY 40536, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY 40536, USA., Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: lauffen@mit.edu., Nikolajczyk BS; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA; Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY 40536, USA. Electronic address: barb.nik@uky.edu.

Publikováno v: Cell metabolism [Cell Metab] 2019 Sep 03; Vol. 30 (3), pp. 447-461.e5. Date of Electronic Publication: 2019 Aug 01.