Study design features that improve effect sizes in cross-sectional and longitudinal brain-wide association studies

Autor: Kang, Kaidi, Seidlitz, Jakob, Bethlehem, Richard A.I., Schildcrout, Jonathan, Tao, Ran, Xiong, Jiangmei, Jones, Megan T., Alexander-Bloch, Aaron, Vandekar, Simon

Publikováno v: bioRxiv

Brain-wide association studies (BWAS) are a fundamental tool in discovering brain-behavior associations. Several recent studies showed that thousands of study participants are required to improve the replicability of BWAS because actual effect sizes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c29731c4cb0f6959187674c1ccbeae4
https://europepmc.org/articles/PMC10312450/

Study design features increase replicability in cross-sectional and longitudinal brain-wide association studies.

Autor: Kang K; Department of Biostatistics, Vanderbilt University Medical Center., Seidlitz J; Department of Child and Adolescent Psychiatry and Behavioral Sciences, The Children's Hospital of Philadelphia.; Department of Psychiatry, University of Pennsylvania.; Lifespan Brain Institute of The Children's Hospital of Philadelphia and Penn Medicine., Bethlehem RAI; Department of Psychology, University of Cambridge., Xiong J; Department of Biostatistics, Vanderbilt University Medical Center., Jones MT; Department of Biostatistics, Vanderbilt University Medical Center., Mehta K; Department of Psychiatry, University of Pennsylvania.; Lifespan Brain Institute of The Children's Hospital of Philadelphia and Penn Medicine.; Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania., Keller AS; Department of Psychiatry, University of Pennsylvania.; Lifespan Brain Institute of The Children's Hospital of Philadelphia and Penn Medicine.; Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania., Tao R; Department of Biostatistics, Vanderbilt University Medical Center., Randolph A; Department of Pediatrics, University of Minnesota Medical School., Larsen B; Department of Pediatrics, University of Minnesota Medical School., Tervo-Clemmens B; Department of Department of Psychiatry & Behavioral Sciences, University of Minnesota Medical School., Feczko E; Department of Pediatrics, University of Minnesota Medical School., Miranda Dominguez O; Department of Pediatrics, University of Minnesota Medical School., Nelson S; Department of Pediatrics, University of Minnesota Medical School., Schildcrout J; Department of Biostatistics, Vanderbilt University Medical Center., Fair D; Department of Pediatrics, University of Minnesota Medical School., Satterthwaite TD; Department of Psychiatry, University of Pennsylvania.; Lifespan Brain Institute of The Children's Hospital of Philadelphia and Penn Medicine.; Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania., Alexander-Bloch A; Department of Child and Adolescent Psychiatry and Behavioral Sciences, The Children's Hospital of Philadelphia.; Department of Psychiatry, University of Pennsylvania.; Lifespan Brain Institute of The Children's Hospital of Philadelphia and Penn Medicine., Vandekar S; Department of Biostatistics, Vanderbilt University Medical Center.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 24. Date of Electronic Publication: 2024 Jun 24.