PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4.

Autor: Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M, Pagan, Julia K

Publikováno v: EMBO Reports; Aug2024, Vol. 25 Issue 8, p3324-3347, 24p

Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability

Autor: Jones, Mathew JK, Colnaghi, Luca, Huang, Tony T

Translesion synthesis polymerases (TLS Pols) are required to tolerate DNA lesions that would otherwise cause replication arrest and cell death. Aberrant expression of these specialized Pols may be responsible for increased mutagenesis and loss of gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5697a18680907027ce3e2344c34f162
https://europepmc.org/articles/PMC3280556/

Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition.

Autor: Vora S; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Andrew A; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Kumar RP; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Nazareth D; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Bonfim-Melo A; Frazer Institute, The University of Queensland, Brisbane, QLD, Australia., Lim Y; Centre for Cancer Biology, University of South Australia, Adelaide, SA, Australia., Ong XY; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Fernando M; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., He Y; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., Hooper JD; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia., McMillan NA; Menzies Health Institute Queensland and School of Medical Science, Griffith University, Gold Coast, QLD, Australia., Urosevic J; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK., Travers J; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK., Saeh J; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK., Kumar S; Centre for Cancer Biology, University of South Australia, Adelaide, SA, Australia., Jones MJ; Frazer Institute, The University of Queensland, Brisbane, QLD, Australia., Gabrielli B; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia. brianG@uq.edu.au.

Publikováno v: Cell death & disease [Cell Death Dis] 2024 Nov 09; Vol. 15 (11), pp. 810. Date of Electronic Publication: 2024 Nov 09.

SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function.

Autor: Coleman KE; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States., Békés M; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States., Chapman JR; Proteomics Laboratory, Division of Advanced Research Technologies, New York University School of Medicine, New York, United States., Crist SB; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States., Jones MJ; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, Unites States., Ueberheide BM; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States.; Proteomics Laboratory, Division of Advanced Research Technologies, New York University School of Medicine, New York, United States., Huang TT; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States.

Publikováno v: ELife [Elife] 2017 May 05; Vol. 6. Date of Electronic Publication: 2017 May 05.