Výsledky vyhledávání - "Jonelle K. Lee"

Supplementary Tables and Figures from PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition–Dependent GSK-3β–Mediated c-Myc and Pim-1 Proteasomal Degradation

Autor: Maria R. Baer, Goutham Narla, Danilo Perrotti, Yin Wang, Jaya Sangodkar, Sandrine Niyongere, Rena G. Lapidus, Shivani Kapoor, Jonelle K. Lee, Christopher M. Bailey, Prerna Singh, Mario Scarpa

Supplementary Table S1. AML patients. Supplementary Table S2. RT-qPCR primers. Supplementary Table S3. IC50 concentrations (nM) of FLT3 inhibitors, PP2A activators and GSK-3beta inhibitors. Supplementary Figure S1. Concurrent PP2A-activating drug tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86eb9d3fab43e2d25f4450c2f3c42655
https://doi.org/10.1158/1535-7163.22522443

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Data from PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition–Dependent GSK-3β–Mediated c-Myc and Pim-1 Proteasomal Degradation

Autor: Maria R. Baer, Goutham Narla, Danilo Perrotti, Yin Wang, Jaya Sangodkar, Sandrine Niyongere, Rena G. Lapidus, Shivani Kapoor, Jonelle K. Lee, Christopher M. Bailey, Prerna Singh, Mario Scarpa

Fms-like tyrosine-like kinase 3 internal tandem duplication (FLT3-ITD) is present in acute myeloid leukemia (AML) in 30% of patients and is associated with short disease-free survival. FLT3 inhibitor efficacy is limited and transient but may be enhan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2921d1b6556415df736f52ed8b400ce1
https://doi.org/10.1158/1535-7163.c.6543381.v1

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Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication

Autor: Shivani Kapoor, Feyruz V. Rassool, Aditi Chatterjee, Ying S. Zou, Julie C. Dunning Hotopp, Jonelle K. Lee, Mario Scarpa, Prerna Singh, Maria R. Baer, Eric S. Tvedte, Moaath Mustafa Ali, Kshama A. Doshi, Robin E. Bromley

Publikováno v: Oncotarget

Acute myeloid leukemia (AML) with fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) relapses with new chromosome abnormalities following chemotherapy, implicating genomic instability. Error-prone alternative non-homologous end-joining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060dfc08d0575ab32e5067cdfc3f63ef
https://doi.org/10.18632/oncotarget.28042

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Abstract 5013: Effects of PP2A-activating drugs on FLT3 inhibitor resistance mediated by diverse mechanisms in acute myeloid leukemia with FLT3-ITD

Autor: Moaath Mustafa Ali, Aditi Chatterjee, Jonelle K. Lee, Mario Scarpa, Maria R. Baer

Publikováno v: Cancer Research. 83:5013-5013

Internal tandem duplication (ITD) of the fms-like tyrosine kinase 3 (FLT3) receptor tyrosine kinase is present in AML cells in 25% of patients, causing constitutive activation and aberrant signaling. FLT3-ITD+ AML patients have a high relapse rate fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::089108148dd37fe43c3318aed3f6aaa9
https://doi.org/10.1158/1538-7445.am2023-5013

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PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition–Dependent GSK-3β–Mediated c-Myc and Pim-1 Proteasomal Degradation

Autor: Rena G. Lapidus, Jaya Sangodkar, Christopher Bailey, Danilo Perrotti, Maria R. Baer, Shivani Kapoor, Mario Scarpa, Yin Wang, Prerna Singh, Goutham Narla, Sandrine Niyongere, Jonelle K. Lee

Publikováno v: Mol Cancer Ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c051710ac45f74b3209aad1e0408be4
https://doi.org/10.1158/1535-7163.mct-20-0663

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Pim Kinase Inhibitor Enhances FLT3 Inhibitor Efficacy through GSK-3β Activation and GSK-3β-Mediated Proteasomal Degradation of c-Myc

Autor: Shivani Kapoor, Maria R. Baer, Jonelle K. Lee, Moaath Mustafa Ali, Rossana Trotta, Mario Scarpa, Aditi Chatterjee, Prerna Singh

Publikováno v: Blood. 138:1163-1163

BACKGROUND Internal tandem duplication in the fms-like tyrosine kinase 3 receptor tyrosine kinase (FLT3-ITD) is present in acute myeloid leukemia (AML) in 30% of patients, associated with poor treatment outcomes due to rapid relapse. FLT3 inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce59aecf5b0df6facf0c42dfcaec0d8a
https://doi.org/10.1182/blood-2021-151737

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PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

Autor: Sandrine Niyongere, Shivani Kapoor, Jonelle K. Lee, Danilo Perrotti, Mario Scarpa, Prerna Singh, Maria R. Baer, Goutham Narla

Publikováno v: Blood. 134:1276-1276

Introduction fms-like tyrosine like kinase 3 internal tandem duplication (FLT3-ITD), present in acute myeloid leukemia (AML) cells of 30% of patients, results in constitutive and aberrant FLT3 signaling and, clinically, short disease-free survival. E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e93a22282ffcd25d80b0f80c21da9cd6
https://doi.org/10.1182/blood-2019-129011

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