Targeting E2F Sensitizes Prostate Cancer Cells to Drug-Induced Replication Stress by Promoting Unscheduled CDK1 Activity

Autor: Mohaddase Hamidi, Ainhoa Eriz, Jone Mitxelena, Larraitz Fernandez-Ares, Igor Aurrekoetxea, Patricia Aspichueta, Ainhoa Iglesias-Ara, Ana M. Zubiaga

Publikováno v: Cancers; Volume 14; Issue 19; Pages: 4952

E2F1/E2F2 expression correlates with malignancy in prostate cancer (PCa), but its functional significance remains unresolved. To define the mechanisms governed by E2F in PCa, we analyzed the contribution of E2F target genes to the control of genome i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dda15439a427aeab07a57905a167b42
http://hdl.handle.net/10810/58133

An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability

Autor: Mónica Álvarez-Fernández, Marcos Malumbres, Aintzane Apraiz, Asier Fullaondo, Ana M. Zubiaga, Jone Mitxelena, Iraia García-Santisteban, Jon Vallejo-Rodríguez

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
Nucleic Acids Research
Repisalud
Instituto de Salud Carlos III (ISCIII)

Corrigendum published on 03 July 2019 Nucleic Acids Research 47 (14) : 7716–7717 (2019) https://doi.org/10.1093/nar/gkz587 The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a990181ff3c42055f1de4a03b5b6ea98
https://doi.org/10.1093/nar/gky218

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Autor: Jone Mitxelena, Aintzane Apraiz, Ana M. Zubiaga

Publikováno v: Journal of Visualized Experiments.

The gene expression program of the cell cycle represents a critical step for understanding cell cycle-dependent processes and their role in diseases such as cancer. Cell cycle-regulated gene expression analysis depends on cell synchronization into sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806bc260c5a3527e197345853aa957de
https://doi.org/10.3791/55745-v

Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+ T lymphocytes

Autor: Virginia Sanchez-Quiles, Blagoy Blagoev, Irina Kratchmarova, Kerman Aloria, Vyacheslav Akimov, Nerea Osinalde, Ana M. Zubiaga, Jone Mitxelena, Jesus M. Arizmendi

Publikováno v: Osinalde, N, Mitxelena, J, Sánchez-Quiles, V, Akimov, V, Aloria, K, Arizmendi, J M, Zubiaga, A M, Blagoev, B & Kratchmarova, I 2016, ' Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+ T lymphocytes ', Molecular and Cellular Proteomics, vol. 15, no. 6, pp. 2076-92 . https://doi.org/10.1074/mcp.M115.057158

Anti-cancer immunotherapies commonly rely on the use of interleukin-2 (IL-2) to promote the expansion of T lymphocytes. IL-2- dependent proliferation is the culmination of a complex network of phosphorylation-driven signaling events that impact on ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd65e747f6f277da17cd20c9fee740e
https://findresearcher.sdu.dk:8443/ws/files/125902922/Nuclear_Phosphoproteomic_Screen_Uncovers_ACLY_as_Mediator_of_IL_2_induced_Proliferation_of_CD4_T_lymphocytes.pdf

E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation

Autor: Aintzane Apraiz, Marcos Malumbres, Jone Mitxelena, Ana M. Zubiaga, Jon Vallejo-Rodríguez

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Nucleic Acids Research

This work was supported by the Spanish Ministry [SAF2012-33551, co-funded by the European RegionalDevelopment fund to A.M.Z., SAF2012-38215 to M.M.,SAF2014-57791-REDC to A.M.Z. and to M.M.]; BasqueGovernment [IT634-13 to A.M.Z.]; University of theBas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f392a614cf53c367f5f1ca34f5632bf
https://doi.org/10.1016/s0959-8049(16)61601-5