Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jone Michelena"'
Autor:
Jone Michelena, Aleksandra Lezaja, Federico Teloni, Thomas Schmid, Ralph Imhof, Matthias Altmeyer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Methods to study anti-cancer drugs cytotoxicity are often low throughput and rely on population average. Here the authors present an automated image-based cytometry method to quantify multiple cytotoxicity parameters in single cells, and use it to st
Externí odkaz:
https://doaj.org/article/69cfbc985a4f4f299345fc43300b4c9c
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1819-1831 (2017)
The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end resection. How this function is regulated locally and across the cell cycle to ch
Externí odkaz:
https://doaj.org/article/14cbcada5c5a401c8f22e758ac8ba292
Autor:
Olatz Zenarruzabeitia, Arantza Infante, Jone Michelena, Ainhoa Eriz, Ainhoa Iglesias-Ara, Noor Mustafa, ANA MARIA ZUBIAGA ELORDIETA
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 311, p 311 (2022)
Addi. Archivo Digital para la Docencia y la Investigación
instname
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 311
International Journal of Molecular Sciences
Addi. Archivo Digital para la Docencia y la Investigación
instname
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 311
International Journal of Molecular Sciences
Targeted disruption of E2f2 in mice causes T-cell hyperactivation and a disproportionate cell cycle entry upon stimulation. However, E2f2−/− mice do not develop a lymphoproliferative condition. We report that E2f2 plays a Fas-dependent anti-apopt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf239b5bde3d767b926f2ddd5cfa982
http://hdl.handle.net/10810/54945
http://hdl.handle.net/10810/54945
DNA double-strand breaks can be repaired by two competing mechanisms, non-homologous end-joining (NHEJ) and homologous recombination (HR). Whether one or the other repair pathway is favored depends on the availability of an undamaged template DNA tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068d222da8bcea28dd71909ee07d3354
https://doi.org/10.1101/2020.02.24.947168
https://doi.org/10.1101/2020.02.24.947168
Autor:
Matthias Altmeyer, Jone Michelena, Aleksandra Lezaja, Federico Teloni, Thomas Schmid, Ralph Imhof
Publikováno v:
Protocol Exchange.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7be29cac2b7e7a850e2b56126395a26
https://doi.org/10.1038/protex.2019.005
https://doi.org/10.1038/protex.2019.005
Autor:
Aleksandra Lezaja, Matthias Altmeyer, Sinan Kilic, Jone Michelena, Eliana Bianco, Ralph Imhof, Marco Gatti
Publikováno v:
The EMBO Journal
The DNA damage response (DDR) generates transient repair compartments to concentrate repair proteins and activate signaling factors. The physicochemical properties of these spatially confined compartments and their function remain poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f73f5400666ea556b9018ddb087d84
Publikováno v:
Life Science Alliance
This study demonstrates how single cell normalization to genome size provides insight into genome function, here in the context of DNA double-strand break repair by 53BP1 versus BRCA1–BARD1.
DNA double-strand breaks can be repaired by non-homo
DNA double-strand breaks can be repaired by non-homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74d22da4f41682112ffaa5753321ae7
https://doi.org/10.26508/lsa.202101023
https://doi.org/10.26508/lsa.202101023
Autor:
Matthias Altmeyer, Thomas Schmid, Aleksandra Lezaja, Jone Michelena, Federico Teloni, Ralph Imhof
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Exploiting the full potential of anti-cancer drugs necessitates a detailed understanding of their cytotoxic effects. While standard omics approaches are limited to cell population averages, emerging single cell techniques currently lack throughput an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd1c6bf9d328ff1992c55c0c762efb6
https://pubmed.ncbi.nlm.nih.gov/29992957
https://pubmed.ncbi.nlm.nih.gov/29992957
Autor:
Jone, Michelena, Matthias, Altmeyer
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1608
Formation of poly(ADP-ribose) (PAR) marks intracellular stress signaling and is notably induced upon DNA damage. PAR polymerases (PARPs) catalyze PAR synthesis upon genotoxic stress and thereby recruit multiple proteins to damaged chromatin. PAR indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::333ea9502e69a47e433d4e7bbc5f2a8e
https://pubmed.ncbi.nlm.nih.gov/28695503
https://pubmed.ncbi.nlm.nih.gov/28695503
Publikováno v:
Cell Reports
Cell reports
Cell Reports, Vol 19, Iss 9, Pp 1819-1831 (2017)
Cell reports
Cell Reports, Vol 19, Iss 9, Pp 1819-1831 (2017)
Summary The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end resection. How this function is regulated locally and across the cell cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8647be573e5708b414cdd945cfe75e