Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jonathon Hull"'
Publikováno v:
British Journal of Biomedical Science, Vol 80 (2023)
Introduction: Scenario-based learning and gamification have many advantages in comparison to traditional didactic teaching methods, including development of many higher-level skills such as analysis and evaluation. It is hoped that these simulations
Externí odkaz:
https://doaj.org/article/2454793ef101436f8a6754d30a3046f8
Autor:
Abdulraof Alqrache, Jonathon Hull
Background: Colorectal cancer is the third most common cancer worldwide, with colon cancer representing 66.7% of cases. Treatment consists of surgical resection and chemotherapy; however, this is less effective at the later stages of the disease. Gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ccb6c1be5371da07a10a45af8a63db
https://doi.org/10.21203/rs.3.rs-2117393/v1
https://doi.org/10.21203/rs.3.rs-2117393/v1
Publikováno v:
Amino Acids
Malignant cells often demonstrate a proliferative advantage when compared to non-malignant cells. However, the rapid growth and metabolism required for survival can also highlight vulnerabilities specific to these malignant cells. One such vulnerabil
Autor:
Jonathon Hull, Chrystalla Antoniou
Publikováno v:
Current Nutrition Reports
Purpose of Review The olive tree (Olea europaea L.) has featured as a significant part of medicinal history, used to treat a variety of ailments within folk medicine. The Mediterranean diet, which is rich in olive products, is testament to Olea europ
Publikováno v:
British Journal of Haematology. 193:72-82
One of the biggest challenges during the COVID-19 pandemic has been maintaining student engagement and providing the best learning experience with limited face-to-face (FTF) contact, and social distancing requirements. Whilst multiple tools are avail
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1990
Reactive oxygen species (ROS) and low molecular weight antioxidants, such as glutathione and ascorbate, are powerful signalling molecules that participate in the control of plant growth and development, and modulate progression through the mitotic ce
Autor:
Susan M. Hutson, Marta Kierzkowska, Patrick G. Kehoe, Myra E. Conway, Jonathon Hull, Emma L. Ashby
Publikováno v:
Ashby, E L, Kierzkowska, M, Hull, J, Kehoe, P G, Hutson, S M & Conway, M E 2016, ' Altered Expression of Human Mitochondrial Branched Chain Aminotransferase in Dementia with Lewy Bodies and Vascular Dementia ', Neurochemical Research . https://doi.org/10.1007/s11064-016-1855-7
Neurochemical Research
Neurochemical Research
Cytosolic and mitochondrial human branched chain aminotransferase (hBCATc and hBCATm, respectively) play an integral role in brain glutamate metabolism. Regional increased levels of hBCATc in the CA1 and CA4 region of Alzheimer's disease (AD) brain t
Autor:
Emily J. Foulstone, Barbara Rees, Andrea Preston, Rosemary Greenwood, Priyanka Mehta, Vyv Salisbury, Jonathan Heywood, Jonathon Hull, Elizabeth Anderson, Rachel Protheroe
Publikováno v:
Experimental hematology. 74
Cytarabine remains the backbone of therapy in acute myeloid leukemia (AML). The ability to assess intracellular cytarabine triphosphate (ara-CTP) levels in patients receiving cytarabine represents a major goal in the prediction of treatment response.
Publikováno v:
Hull, J, Usmari Moraes, M, Brookes, E, Love, S & Conway, M E 2018, ' Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism ', Neurochemistry International, vol. 112, pp. 49-58 . https://doi.org/10.1016/j.neuint.2017.10.014
Glutamate is the major excitatory neurotransmitter of the central nervous system, with the branched-chain amino acids (BCAAs) acting as key nitrogen donors for de novo glutamate synthesis. Despite the importance of these major metabolites, their meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec87a8f92b3f515c604537907e07aaf
http://www.scopus.com/inward/record.url?scp=85034023534&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85034023534&partnerID=8YFLogxK
Autor:
Katy A Chalmers, Christopher Lee, Maya El Hindy, Patrick G. Kehoe, Vinood B. Patel, Mohammed Hezwani, Esther Odeleye, Seth Love, Myra E. Conway, Jonathon Hull
Publikováno v:
Journal of Alzheimer's Disease. 45:891-905
BACKGROUND The human branched chain aminotransferases (hBCATm, mitochondrial and hBCATc, cytosolic) are major contributors to brain glutamate production. This excitatory neurotransmitter is thought to contribute to neurotoxicity in neurodegenerative