Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jonathon D Walsh"'
Autor:
Jonathon D Walsh, Juan Wang, Molly DeHart, Inna A Nikonorova, Jagan Srinivasan, Maureen M Barr
Publikováno v:
PLoS Genetics, Vol 18, Iss 12, p e1010560 (2022)
The cilium acts as an antenna receiving and sending signals, the latter via extracellular vesicles (EVs). In C. elegans and mammals, the Autosomal Dominant Polycystic Kidney Disease (ADPKD) gene products polycystin-1 (PC1) and polycystin-2 (PC2) loca
Externí odkaz:
https://doaj.org/article/4c305ba884dc44868391692cdd220c41
Autor:
Kade M Power, Jyothi S Akella, Amanda Gu, Jonathon D Walsh, Sebastian Bellotti, Margaret Morash, Winnie Zhang, Yasmin H Ramadan, Nicole Ross, Andy Golden, Harold E Smith, Maureen M Barr, Robert O'Hagan
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009052 (2020)
Ciliary microtubules are subject to post-translational modifications that act as a "Tubulin Code" to regulate motor traffic, binding proteins and stability. In humans, loss of CCP1, a cytosolic carboxypeptidase and tubulin deglutamylating enzyme, cau
Externí odkaz:
https://doaj.org/article/c31953d4b8684ae9b72f982eed9b6462
Autor:
Jenna L Wingfield, Ilaria Mengoni, Heather Bomberger, Yu-Yang Jiang, Jonathon D Walsh, Jason M Brown, Tyler Picariello, Deborah A Cochran, Bing Zhu, Junmin Pan, Jonathan Eggenschwiler, Jacek Gaertig, George B Witman, Peter Kner, Karl Lechtreck
Publikováno v:
eLife, Vol 6 (2017)
Intraflagellar transport (IFT) trains, multimegadalton assemblies of IFT proteins and motors, traffic proteins in cilia. To study how trains assemble, we employed fluorescence protein-tagged IFT proteins in Chlamydomonas reinhardtii. IFT-A and motor
Externí odkaz:
https://doaj.org/article/d5e81191a8b840c585d4a90e0e20d613
Publikováno v:
Journal of Neurogenetics. 34:323-334
Sexual dimorphism is a device that supports genetic diversity while providing selective pressure against speciation. This phenomenon is at the core of sexually reproducing organisms. Caenorhabditis elegans provides a unique experimental system where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ada02186ed467fd6cdddf2b9c1f84bca
https://doi.org/10.1080/01677063.2020.1789978
https://doi.org/10.1080/01677063.2020.1789978
Publikováno v:
Nature's Gift to Neuroscience ISBN: 9781003239758
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fb2cafed2e622b135a61c41b2e3aedd
https://doi.org/10.1201/9781003239758-14
https://doi.org/10.1201/9781003239758-14
Autor:
Jyothi S. Akella, Alexander L. Cope, Peter Tilton, Inna A. Nikonorova, Kaiden M. Power, Premal Shah, Jonathon D. Walsh, Maureen M. Barr, Amber R. Krauchunas, Juan Wang
Extracellular vesicle (EV)-based signaling is a challenge to study, due to EV small size, heterogeneity, and limited information on cargo content in vivo. We present Caenorhabditis elegans as a discovery platform that allows single EV tracking from s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90a9dcebd14c174940ca16655736083e
https://doi.org/10.1101/2021.09.23.461577
https://doi.org/10.1101/2021.09.23.461577
Autor:
Amanda Gu, Maureen M. Barr, Malan Silva, Peter Tilton, Juan Wang, Inna A. Nikonorova, Jonathon D. Walsh
Extracellular vesicles play major roles in intercellular signaling, yet fundamental aspects of their biology remain poorly understood. Ciliary EV shedding is evolutionary conserved. Here we use super resolution, real time imaging of fluorescent-prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1980757be0884832953a25c3be77511e
https://doi.org/10.1101/2021.02.04.429799
https://doi.org/10.1101/2021.02.04.429799
Autor:
Jyothi S. Akella, Amanda Gu, Jonathon D. Walsh, Maureen M. Barr, Inna A. Nikonorova, Peter Tilton, Juan Wang, Malan Silva
Publikováno v:
Curr Biol
Ciliary extracellular vesicle (EV) shedding is evolutionarily conserved. In Chlamydomonas and C. elegans, ciliary EVs act as signaling devices [1–3]. In cultured mammalian cells, ciliary EVs regulate ciliary disposal but also receptor abundance and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baaf8d9aff9c3b8dce5cef370b11f1c6
https://doi.org/10.2139/ssrn.3788465
https://doi.org/10.2139/ssrn.3788465
Autor:
Inna A. Nikonorova, Juan Wang, Alexander L. Cope, Peter E. Tilton, Kaiden M. Power, Jonathon D. Walsh, Jyothi S. Akella, Amber R. Krauchunas, Premal Shah, Maureen M. Barr
Publikováno v:
Curr Biol
Extracellular vesicles (EVs) may mediate intercellular communication by carrying protein and RNA cargo. The composition, biology, and roles of EVs in physiology and pathology have been primarily studied in the context of biofluids and in cultured mam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47c5b8390a894c1fc10faaeef38408f
https://doi.org/10.1016/j.cub.2022.03.005
https://doi.org/10.1016/j.cub.2022.03.005
CRISPR/Cas9 mutagenesis is a revolutionary tool for genetics in organismal and cell culture systems. One notable caveat with this system is the potential for phenotype-inducing off-target/background mutations. There has been considerable success in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f709f7716a938d4709d8376fd1cc45e
https://doi.org/10.1101/2020.09.07.286187
https://doi.org/10.1101/2020.09.07.286187