Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Jonathon C Arnold"'
Autor:
Lyndsey L Anderson, Dilara A Bahceci, Nicole A Hawkins, Declan Everett-Morgan, Samuel D Banister, Jennifer A Kearney, Jonathon C Arnold
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280842 (2023)
A purified preparation of cannabidiol (CBD), a cannabis constituent, has been approved for the treatment of intractable childhood epilepsies such as Dravet syndrome. Extensive pharmacological characterization of CBD shows activity at numerous molecul
Externí odkaz:
https://doaj.org/article/bb7a769529cf4d5fb03fb7d3a0df6512
Autor:
Brendon J Yee, Ronald R Grunstein, Christopher J Gordon, Anastasia Suraev, Nathaniel S Marshall, Angela L D'Rozario, Delwyn J Bartlett, Keith Wong, Ryan Vandrey, Chris Irwin, Jonathon C Arnold, Iain S McGregor, Camilla M Hoyos
Publikováno v:
BMJ Open, Vol 10, Iss 5 (2020)
Introduction Insomnia is a highly prevalent and costly condition that is associated with increased health risks and healthcare utilisation. Anecdotally, cannabis use is frequently reported by consumers to promote sleep. However, there is limited rese
Externí odkaz:
https://doaj.org/article/60a0e6e5c2df4c14b67eb6abec2220c2
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70052 (2013)
Recent analysis of the cannabinoid content of cannabis plants suggests a shift towards use of high potency plant material with high levels of Δ(9)-tetrahydrocannabinol (THC) and low levels of other phytocannabinoids, particularly cannabidiol (CBD).
Externí odkaz:
https://doaj.org/article/912f1f8e80dc4fb0b8e876ba52de3d65
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35937 (2012)
The ABC transporters P-glycoprotein (P-gp, Abcb1) and breast cancer resistance protein (Bcrp, Abcg2) regulate the CNS disposition of many drugs. The main psychoactive constituent of cannabis Δ(9)-tetrahydrocannabinol (THC) has affinity for P-gp and
Externí odkaz:
https://doaj.org/article/364e65f05c8f459a8c22b8a216d1119e
Autor:
Leonora E Long, Rose Chesworth, Xu-Feng Huang, Alexander Wong, Adena Spiro, Iain S McGregor, Jonathon C Arnold, Tim Karl
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34129 (2012)
The cannabis constituent cannabidiol (CBD) possesses anxiolytic and antipsychotic properties. We have previously shown that transmembrane domain neuregulin 1 mutant (Nrg1 TM HET) mice display altered neurobehavioural responses to the main psychoactiv
Externí odkaz:
https://doaj.org/article/69c3ecc4cc634d11bc40653edef597cb
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27237 (2011)
Previous studies have suggested that administration of oxytocin (OT) can have modulatory effects on social and anxiety-like behavior in mammals that may endure beyond the time of acute OT administration. The current study examined whether repeated ad
Externí odkaz:
https://doaj.org/article/688e9bea44914497910f03a59cca10cd
Publikováno v:
Clinical and Translational Science. 16:10-30
Global interest in the non-intoxicating cannabis constituent, cannabidiol (CBD), is increasing with claims of therapeutic effects across a diversity of health conditions. At present, there is sufficient clinical trial evidence to support the use of h
Autor:
Lyndsey L. Anderson, Declan Everett‐Morgan, Stela P. Petkova, Jill L. Silverman, Jonathon C. Arnold
Publikováno v:
Epilepsia Open.
Publikováno v:
Frontiers in Physiology. 14