Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jonathan Zhangi Ho"'
Autor:
Jonathan Zhangi Ho, Susanne M Anderson, Daniel V. Siev, Kemp Scott Jeffrey, Thomas G. Nolan, John A. Gaudette, Annette E Bradbury, Nathaniel K. Minami, Komandla Malla Reddy, Gian-Luca Araldi, John E Reiner, Lala Mamedova, Tony Gibson, Jingrong Jean Cui, J. Edward Semple
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2925-2930
Novel, potent, and highly selective classes of thrombin inhibitors were identified, which resulted from judicious combination of P4-aromatics and P2-P3-heterocyclic dipeptide surrogates with weakly basic (calcd pKa approximately non-basic-8.6) bicycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28d17be750a8171e753d60364adb4bc
https://doi.org/10.1016/s0960-894x(02)00585-1
https://doi.org/10.1016/s0960-894x(02)00585-1
Publikováno v:
ChemInform. 33
Evolution of P 1 -argininal inhibitor prototypes led to a series of non-covalent P 3 -7-membered lactam inhibitors 1a – w , featuring novel peptidomimetic units that probe each of the S 1 , S 2 , and S 3 specificity pockets of thrombin. Rigid P 1 -
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::334df2d7be24c6a04f9b26902743dbc1
https://doi.org/10.1002/chin.200225152
https://doi.org/10.1002/chin.200225152
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(5)
Evolution of P 1 -argininal inhibitor prototypes led to a series of non-covalent P 3 -7-membered lactam inhibitors 1a – w , featuring novel peptidomimetic units that probe each of the S 1 , S 2 , and S 3 specificity pockets of thrombin. Rigid P 1 -
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a07be3e2e65e6ef65d90b373e081fb2
https://pubmed.ncbi.nlm.nih.gov/11858993
https://pubmed.ncbi.nlm.nih.gov/11858993