Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Jonathan Z. Long"'
Autor:
Veronica L. Li, Shuke Xiao, Pascal Schlosser, Nora Scherer, Amanda L. Wiggenhorn, Jan Spaas, Alan Sheng-Hwa Tung, Edward D. Karoly, Anna Köttgen, Jonathan Z. Long
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe transport across cell membranes. Here we identify SLC17A1 and SLC17A3, t
Externí odkaz:
https://doaj.org/article/9695338dd6d846c7b9822aa0332783dc
Autor:
Cody Durrer, Hashim Islam, Haoning Howard Cen, Maria Dolores Moya Garzon, Xuchao Lyu, Sean McKelvey, Joel Singer, Alan M. Batterham, Jonathan Z. Long, James D. Johnson, Jonathan P. Little
Publikováno v:
Nutrition & Metabolism, Vol 21, Iss 1, Pp 1-10 (2024)
Abstract Background Substantial weight loss in people living with type 2 diabetes (T2D) can reduce the need for glucose-lowering medications while concurrently lowering glycemia below the diagnostic threshold for the disease. Furthermore, weight-loss
Externí odkaz:
https://doaj.org/article/93f13911ef7b4a3c8ed58a8449e3284a
Autor:
Shixuan Liu, Camille Ezran, Michael F. Z. Wang, Zhengda Li, Kyle Awayan, The Tabula Microcebus Consortium, Jonathan Z. Long, Iwijn De Vlaminck, Sheng Wang, Jacques Epelbaum, Christin S. Kuo, Jérémy Terrien, Mark A. Krasnow, James E. Ferrell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, and health. Traditionally, endocrinologists have focused on one hormone or organ system at a time. Yet, hormone signaling by its very nature conne
Externí odkaz:
https://doaj.org/article/238c63958cb94f9a87c3cbab28ca495c
Autor:
Amanda L. Wiggenhorn, Hind Z. Abuzaid, Laetitia Coassolo, Veronica L. Li, Julia T. Tanzo, Wei Wei, Xuchao Lyu, Katrin J. Svensson, Jonathan Z. Long
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Peptide hormones and neuropeptides are signaling molecules that control diverse aspects of mammalian homeostasis and physiology. Here we provide evidence for the endogenous presence of a sequence diverse class of blood-borne peptides that we
Externí odkaz:
https://doaj.org/article/28bde66131474eb9b3397bf0fc47ccc5
Autor:
Robert A. Saxton, Nathanael A. Caveney, Maria Dolores Moya-Garzon, Karsten D. Householder, Grayson E. Rodriguez, Kylie A. Burdsall, Jonathan Z. Long, K. Christopher Garcia
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Leptin is an adipocyte-derived protein hormone that promotes satiety and energy homeostasis by activating the leptin receptor (LepR)–STAT3 signaling axis in a subset of hypothalamic neurons. Leptin signaling is dysregulated in obesity, how
Externí odkaz:
https://doaj.org/article/3604942e453f41839c0e226870f2d718
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 101014- (2021)
Summary: Secreted polypeptides represent a fundamental axis of intercellular communication. Here, we present a protocol for the cell type-specific biotinylation, enrichment, and proteomic profiling of secreted plasma proteins directly in mice. This p
Externí odkaz:
https://doaj.org/article/47c2c730f76d4618ac68f3b6bac68424
Autor:
Debby Ngo, Mark D. Benson, Jonathan Z. Long, Zsu-Zsu Chen, Ruiqi Wang, Anjali K. Nath, Michelle J. Keyes, Dongxiao Shen, Sumita Sinha, Eric Kuhn, Jordan E. Morningstar, Xu Shi, Bennet D. Peterson, Christopher Chan, Daniel H. Katz, Usman A. Tahir, Laurie A. Farrell, Olle Melander, Jonathan D. Mosley, Steven A. Carr, Ramachandran S. Vasan, Martin G. Larson, J. Gustav Smith, Thomas J. Wang, Qiong Yang, Robert E. Gerszten
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Recent advances in proteomic technologies have made high-throughput profiling of low-abundance proteins in large epidemiological cohorts increasingly feasible. We investigated whether aptamer-based proteomic profiling could identify biomarkers associ
Externí odkaz:
https://doaj.org/article/22cf2c5275cd449ea1851179ea631da1
Autor:
Colin J. Palmer, Raphael J. Bruckner, Joao A. Paulo, Lawrence Kazak, Jonathan Z. Long, Amir I. Mina, Zhaoming Deng, Katherine B. LeClair, Jessica A. Hall, Shangyu Hong, Peter-James H. Zushin, Kyle L. Smith, Steven P. Gygi, Susan Hagen, David E. Cohen, Alexander S. Banks
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1212-1225 (2017)
Objectives: Understanding how loci identified by genome wide association studies (GWAS) contribute to pathogenesis requires new mechanistic insights. Variants within CDKAL1 are strongly linked to an increased risk of developing type 2 diabetes and ob
Externí odkaz:
https://doaj.org/article/f3cec99c9ddb4aa8b55ee9cedc2b1b4e
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 2, Pp 337-344 (2011)
Fatty acid amide hydrolase (FAAH) regulates amidated lipid transmitters, including the endocannabinoid anandamide and its N-acyl ethanolamine (NAE) congeners and transient receptor potential channel agonists N-acyl taurines (NATs). Using both the FAA
Externí odkaz:
https://doaj.org/article/5fd54f8290fa4e71be4da82b4e0f03ea
Publikováno v:
eLife, Vol 9 (2020)
The N-acyl amino acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy homeostasis. Their endogenous levels are regulated by an extracellular mammalian N-acyl amino acid synthase/hydrolase called PM20D1 (p
Externí odkaz:
https://doaj.org/article/462d15a66410454b9773bc0ee1e2b729