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pro vyhledávání: '"Jonathan Yew Seng Ho"'
Autor:
Mark Parta, Karen M. Frank, Jamie K. Lemon, Pavel P. Khil, John P. Dekker, Robert A. Bonomo, Jung-Ho Youn, Juan Gea-Banacloche, Augusto Dulanto Chiang, Jonathan Yew Seng Ho
Publikováno v:
mBio, Vol 10, Iss 5, p e01822-19 (2019)
mBio
mBio, Vol 10, Iss 5 (2019)
mBio
mBio, Vol 10, Iss 5 (2019)
Antimicrobial resistance in bacteria represents one of the most consequential problems in modern medicine, and its emergence and spread threaten to compromise central advances in the treatment of infectious diseases. Ceftazidime-avibactam (CZA) belon
Autor:
Layla F. Saidi, James H. Hurley, Bertram Canagarajah, Jonathan Yew Seng Ho, Marcelo G. Kazanietz, Harald Mischak, Federico Coluccio Leskow
Publikováno v:
Cell. 119(3):407-418
The lipid second messenger diacylglycerol acts by binding to the C1 domains of target proteins, which translocate to cell membranes and are allosterically activated. Here we report the crystal structure at 3.2 A resolution of one such protein, beta2-