Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jonathan Y. Hsu"'
Autor:
Jonathan Y. Hsu, Julian Grünewald, Regan Szalay, Justine Shih, Andrew V. Anzalone, Kin Chung Lam, Max W. Shen, Karl Petri, David R. Liu, J. Keith Joung, Luca Pinello
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Prime editing guide RNA design is more complex than for standard CRISPR-based nucleases or base editors. Here the authors present PrimeDesign and PrimeVar for the rapid and simplified design of pegRNA and ngRNA combinations.
Externí odkaz:
https://doaj.org/article/641f29fd5ac64f28bbea06a81c5212bd
Autor:
Huidong Chen, Luca Albergante, Jonathan Y. Hsu, Caleb A. Lareau, Giosuè Lo Bosco, Jihong Guan, Shuigeng Zhou, Alexander N. Gorban, Daniel E. Bauer, Martin J. Aryee, David M. Langenau, Andrei Zinovyev, Jason D. Buenrostro, Guo-Cheng Yuan, Luca Pinello
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The increasing accessibility of single cell omics technologies beyond transcriptomics demands parallel advances in analysis. Here, the authors introduce STREAM, a pipeline for reconstruction and visualization of differentiation trajectories from both
Externí odkaz:
https://doaj.org/article/a8fc084be2f940a8842ac27783508d69
Autor:
Benjamin Lacar, Sara B. Linker, Baptiste N. Jaeger, Suguna Rani Krishnaswami, Jerika J. Barron, Martijn J. E. Kelder, Sarah L. Parylak, Apuã C. M. Paquola, Pratap Venepally, Mark Novotny, Carolyn O'Connor, Conor Fitzpatrick, Jennifer A. Erwin, Jonathan Y. Hsu, David Husband, Michael J. McConnell, Roger Lasken, Fred H. Gage
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The molecular dynamics associated with neuronal activation patterns in vivo are unclear. Lacar et al. perform single-nuclei RNA-sequencing of hippocampal neurons from mice exposed to a novel environment, and identify large-scale transcriptome changes
Externí odkaz:
https://doaj.org/article/945908deb567490ab967344cc571a206
Autor:
Benjamin Lacar, Sara B. Linker, Baptiste N. Jaeger, Suguna Rani Krishnaswami, Jerika J. Barron, Martijn J. E. Kelder, Sarah L Parylak, Apuã C. M. Paquola, Pratap Venepally, Mark Novotny, Carolyn O’Connor, Conor Fitzpatrick, Jennifer A. Erwin, Jonathan Y. Hsu, David Husband, Michael J. McConnell, Roger Lasken, Fred H. Gage
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 7: Article number: 11022 (2016); Published 19 April 2016; Updated 17 March 2017 An incorrect version of Supplementary Data 1, in which normalized counts were analysed instead of raw counts, resulting in a smaller number of diffe
Externí odkaz:
https://doaj.org/article/f31904b35b4948faadb5285253683701
Autor:
Benjamin Lacar, Sara B. Linker, Baptiste N. Jaeger, Suguna Rani Krishnaswami, Jerika J. Barron, Martijn J. E. Kelder, Sarah L. Parylak, Apuã C. M. Paquola, Pratap Venepally, Mark Novotny, Carolyn O’Connor, Conor Fitzpatrick, Jennifer A. Erwin, Jonathan Y. Hsu, David Husband, Michael J. McConnell, Roger Lasken, Fred H. Gage
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 7: Article number:11022 (2016); Published 19 April 2016; Updated 14 June 2016 In the original version of this Article, the middle names or initials of the authors Suguna Rani Krishnaswami, Jerika J. Barron, Martijn J.E. Kelder,
Externí odkaz:
https://doaj.org/article/5684b7501cfc453aae6e218622c3bb80
Autor:
Qiuming Yao, Daniel E. Bauer, Jonathan Y. Hsu, Stuart H. Orkin, Qian Zhu, Luca Pinello, Yan Kai, Phraew Sakon, Guo-Cheng Yuan, Nan Liu, Shuqian Xu
Publikováno v:
Nature genetics
Nat Genet
Nat Genet
BCL11A, the major regulator of fetal hemoglobin (HbF, α2γ2) level, represses γ-globin expression through direct promoter binding in adult erythroid cells in a switch to adult hemoglobin (HbA, α2β2). To uncover how BCL11A initiates repression, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb284071c95b43620f661f9a445790e2
http://europepmc.org/articles/PMC8038971
http://europepmc.org/articles/PMC8038971
Autor:
Luca Pinello, Max W. Shen, Regan Szalay, Julian Grünewald, Jonathan Y. Hsu, J. Keith Joung, Andrew V. Anzalone, Justine Shih, David R. Liu, Kin Chung Lam, Karl Petri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Nature Communications
Nature Communications
Prime editing (PE) is a versatile genome editing technology, but design of the required guide RNAs is more complex than for standard CRISPR-based nucleases or base editors. Here we describe PrimeDesign, a user-friendly, end-to-end web application and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef65e9d4e85e74b4a85709efb6e1dc2
https://doaj.org/article/641f29fd5ac64f28bbea06a81c5212bd
https://doaj.org/article/641f29fd5ac64f28bbea06a81c5212bd
Publikováno v:
Mol Cell
The CRISPR-Cas system offers a programmable platform for eukaryotic genome and epigenome editing. The ability to perform targeted genetic and epigenetic perturbations enables researchers to perform a variety of tasks, ranging from investigating quest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7534404d5151b11eabfb88b724283d0e
https://doi.org/10.1016/j.molcel.2020.06.012
https://doi.org/10.1016/j.molcel.2020.06.012
Autor:
Jonathan Y. Hsu, Martin J. Aryee, Ronghao Zhou, J. Keith Joung, Lukas M. Langner, Sara P. Garcia, Bret R. Miller, Julian Grünewald, Sowmya Iyer, Caleb A. Lareau
Publikováno v:
Nature biotechnology
Existing adenine and cytosine base editors induce only a single type of modification, limiting the range of DNA alterations that can be created. Here we describe a CRISPR-Cas9-based synchronous programmable adenine and cytosine editor (SPACE) that ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4372198978a9c533af57b06ded868f53
https://doi.org/10.1038/s41587-020-0535-y
https://doi.org/10.1038/s41587-020-0535-y
Autor:
Luca Pinello, Gengyang Yuan, Luca Albergante, Jonathan Y. Hsu, Jason D. Buenrostro, David M. Langenau, Caleb A. Lareau, Shuigeng Zhou, Andrei Zinovyev, Martin J. Aryee, Huidong Chen, Alexander N. Gorban, Daniel E. Bauer, Jihong Guan, Giosuè Lo Bosco
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Single-cell transcriptomic assays have enabled the de novo reconstruction of lineage differentiation trajectories, along with the characterization of cellular heterogeneity and state transitions. Several methods have been developed for reconstructing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b0790162d86f8e65ac7fc27021b1ea
https://doaj.org/article/a8fc084be2f940a8842ac27783508d69
https://doaj.org/article/a8fc084be2f940a8842ac27783508d69