Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jonathan Y. Bass"'
Autor:
Harry B. Marr, Kevin P. Madauss, Jonathan Y. Bass, Shawn P. Williams, Dan Todd, Paul Kenneth Spearing, Adwoa Akwabi-Ameyaw, Lihong Chen, Robert B. McFadyen, Justin A. Caravella, Derek J. Parks, Frank Navas, David N. Deaton, Katrina L. Creech, G. Bruce Wisely, Richard Dana Caldwell, Aaron B. Miller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4733-4739
Two series of conformationally constrained analogs of the FXR agonist GW 4064 1 were prepared. Replacement of the metabolically labile stilbene with either benzothiophene or naphthalene rings led to the identification of potent full agonists 2a and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537fc0c9b0822e4038f1ffd07428e5e6
https://doi.org/10.1016/j.bmcl.2009.06.062
https://doi.org/10.1016/j.bmcl.2009.06.062
Autor:
Justin A. Caravella, David N. Deaton, Katrina L. Creech, G. Bruce Wisely, Jonathan Y. Bass, Lihong Chen, Harry B. Marr, Robert B. McFadyen, Shawn P. Williams, Richard Dana Caldwell, Kevin P. Madauss, Aaron B. Miller, Derek J. Parks, Dan Todd
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2969-2973
Starting from the known FXR agonist GW 4064 1a, a series of alternately 3,5-substituted isoxazoles was prepared. Several of these analogs were potent full FXR agonists. A subset of this series, with a tether between the isoxazole ring and the 3-posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecaaf14e70189436e51664e2f641b1ca
https://doi.org/10.1016/j.bmcl.2009.04.047
https://doi.org/10.1016/j.bmcl.2009.04.047
Autor:
Lihong Chen, Jonathan Y. Bass, David N. Deaton, Aaron B. Miller, Justin A. Caravella, Istvan Kaldor, Robert B. McFadyen, Stacey A. Jones, Dan Todd, Paul Kenneth Spearing, Kevin P. Madauss, Adwoa Akwabi-Ameyaw, Derek J. Parks, Richard Dana Caldwell, Frank Navas, Yaping Liu, Katrina L. Creech, G. Bruce Wisely, Harry B. Marr, Shawn P. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4339-4343
Starting from the known FXR agonist GW 4064 1a, a series of stilbene replacements were prepared. The 6-substituted 1-naphthoic acid 1b was an equipotent FXR agonist with improved developability parameters relative to 1a. Analog 1b also reduced the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519480e527d445babf5d509d5d05a857
https://doi.org/10.1016/j.bmcl.2008.06.073
https://doi.org/10.1016/j.bmcl.2008.06.073
Autor:
Jonathan Y. Bass, Oscar Navarro, Neeladri Das, Stephen M. Canham, Suzanne A. Blum, Sung-Gon Lim
Publikováno v:
Organometallics. 27:2172-2175
The single-molecule fluorescence microscopy imaging of individual palladium(II) complexes is reported and the requisite high-quantum-yield BODIPY fluorophore tags are synthesized and shown to act as spectators when bound to metal complexes. These com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::883371dbd825dd0a1e369a6285057157
https://doi.org/10.1021/om800228v
https://doi.org/10.1021/om800228v
Publikováno v:
Inorganic Chemistry. 50:9201-9203
The subensemble kinetics of a platinum-sulfur covalent chemical reaction at the solution/surface interface of a model industrial catalyst support was examined using single-molecule fluorescence microscopy (SMFM) and was found to exhibit biexponential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65aa038ea05d8d8ba888ab4fe232cff5
https://doi.org/10.1021/ic2007952
https://doi.org/10.1021/ic2007952
Autor:
Justin A. Caravella, Terrence L. Smalley, Jonathan Y. Bass, Kevin P. Madauss, Aaron B. Miller, Robert B. McFadyen, Katrina L. Creech, G. Bruce Wisely, Harry B. Marr, Lihong Chen, Dan Todd, Shawn P. Williams, David N. Deaton, Paul Kenneth Spearing, Derek J. Parks, Frank Navas, Wendy Y. Mills
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(4)
To improve on the drug properties of GSK8062 1b, a series of heteroaryl bicyclic naphthalene replacements were prepared. The quinoline 1c was an equipotent FXR agonist with improved drug developability parameters relative to 1b. In addition, analog 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fde8626b56404560d9578dd0bfc42d
https://pubmed.ncbi.nlm.nih.gov/21256005
https://pubmed.ncbi.nlm.nih.gov/21256005
Autor:
Jonathan Y. Bass, Ming H. Cheng, Vladimir A. Mandelshtam, Trevor P. Cornell, Douglas A. L. Otte, Theresa M. McIntire, Yong Wang, John C. Hemminger, N. Melody Esfandiari, Suzanne A. Blum
Publikováno v:
Journal of the American Chemical Society. 132(43)
Single-molecule fluorescence microscopy provided information about the real-time distribution of chemical reactivity on silicon oxide supports at the solution−surface interface, at a level of detail which would be unavailable from a traditional ens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e83dc67024e8b4a5685076d6875b081
https://pubmed.ncbi.nlm.nih.gov/20731349
https://pubmed.ncbi.nlm.nih.gov/20731349
Autor:
Jonathan Y. Bass, Melissa B. Secosky-Chang, Dallas K. Croom, Paul R. Johnson, Steven Michael Reister, Curt D. Haffner, Jing Fang, Thaddeus A. Tomaszek, Christopher R. Conlee, Donavon J McConn, Darryl Lynn Mcdougald, Kevin J. Wells-Knecht, James M. Lenhard, Brian Thompson
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(23)
We report the synthesis and biological activity of a series of 2-cyano-4-fluoro-1-thiovalylpyrrolidine inhibitors of DPP-IV. Within this series, compound 19 provided a potent, selective, and orally active DPP-IV inhibitor which demonstrated a very lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4811373062218e9c37554b0a1ca38256
https://pubmed.ncbi.nlm.nih.gov/16168640
https://pubmed.ncbi.nlm.nih.gov/16168640
Autor:
Stephen M. Canham, Jonathan Y. Bass, Oscar Navarro, Sung-Gon Lim, Neeladri Das, Suzanne A. Blum
Publikováno v:
Organometallics; Apr2008, Vol. 27 Issue 10, p2172-2175, 4p