Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jonathan Wilhelm"'
Autor:
Qiang Feng, Zhida Liu, Xuexin Yu, Tongyi Huang, Jiahui Chen, Jian Wang, Jonathan Wilhelm, Suxin Li, Jiwon Song, Wei Li, Zhichen Sun, Baran D. Sumer, Bo Li, Yang-Xin Fu, Jinming Gao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Lactic acid from glycolytic metabolism of cancer cells has been associated with immune suppressive functions. Here authors show that lactate, when depart from the acidic protons, inhibits histone deacetylases in CD8 + T cells, which turns them into p
Externí odkaz:
https://doaj.org/article/f046c8ae08fc4d8a94ca232b1d378b19
Autor:
Jian Wang, Min Luo, Xinyu Zhang, Jinming Gao, Gang Huang, Jayanthi Lea, Yuwei Li, Jun Cao, Xiaoyi Jiang, Xichen Zheng, Zhida Liu, Jonathan Wilhelm, Jinlan Zhang, Baran Sumer, Zhigang Lu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 5 (2022)
Background Cancer vaccines are able to achieve tumor-specific immune editing in early-phase clinical trials. However, the infiltration of cytotoxic T cells into immune-deserted tumors is still a major limiting factor. An optimized vaccine approach to
Externí odkaz:
https://doaj.org/article/49477d19cd224b38804ffb63795be6eb
Autor:
Xu Wang, Jonathan Wilhelm, Wei Li, Suxin Li, Zhaohui Wang, Gang Huang, Jian Wang, Houliang Tang, Sina Khorsandi, Zhichen Sun, Bret Evers, Jinming Gao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Stimuli-responsive nanomaterials offer the opportunity to exploit nanoscale cooperativity to improve the precision of diagnostic or therapeutic outcomes. Here, the authors report the design, synthesis and characterization of a series of degradable ul
Externí odkaz:
https://doaj.org/article/9d311122c77848918b4ada92cf5fbb74
Autor:
Qiang Feng, Gang Huang, Raymundo Pantoja, Zhichen Sun, Wei Li, Katy Torres, Jonathan Wilhelm, Zirong Chen, Tian Zhao, Ruolan Han, Jinming Gao
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Baran D. Sumer, Jian Wang, Zhaohui Wang, Jinming Gao, Li Wei, Qiang Feng, Xu Wang, Suxin Li, Hongtao Yu, Agnieszka Cholka, Min Luo, Yang Xin Fu, Jonathan Wilhelm
Publikováno v:
Nature Biomedical Engineering
The stimulator of interferon genes (STING) is an endoplasmic reticulum transmembrane protein that is a target of therapeutics for infectious diseases and cancer. However, early-phase clinical trials of small-molecule STING agonists have shown limited
Autor:
Suxin Li, Jian Wang, Jonathan Wilhelm, Qingtai Su, Gaurav Bharadwaj, Jason Miller, Wei Li, Katy Torres, Ruolan Han, Tian Zhao, Jinming Gao
Publikováno v:
Cancer Research. 82:4234-4234
Background: The stimulator of interferon genes (STING) plays a central role in innate immune response against infection and cancer. Several cyclic di-nucleotide (CDN) and non-CDN small molecule STING agonists have demonstrated effectiveness against c
Publikováno v:
Adv Drug Deliv Rev
Precise spatiotemporal control of molecular transport is vital to functional physiological systems. Nature evolved to apply macromolecular cooperativity to achieve precision over systemic delivery of important molecules. In drug delivery, conventiona
Autor:
Andre G. Montoya‐Barthelemy, Karyn Leniek, Emily Bannister, Marcus Rushing, Fozia A. Abrar, Tobias E. Baumann, Madeleine Manly, Jonathan Wilhelm, Ashley Niece, Scott Riester, Hyun Kim, Jonathan Sellman, Jay Desai, Paul J. Anderson, Ralph S. Bovard, Nicolas P. Pronk, Zeke J. McKinney
Publikováno v:
American journal of industrial medicine. 65(5)
Although racial and ethnic identities are associated with a multitude of disparate medical outcomes, surveillance of these subpopulations in the occupational clinic setting could benefit enormously from a more detailed and nuanced recognition of raci
Autor:
Suxin Li, Min Luo, Zhaohui Wang, Qiang Feng, Jonathan Wilhelm, Xu Wang, Wei Li, Jian Wang, Qingtai Su, Gaurav Bharadwaj, Jason Miller, Katy Torres, Stephen Gutowski, Agnieszka Cholka, Yang-xin Fu, Tian Zhao, Baran Sumer, Hongtao Yu, Jinming Gao
Publikováno v:
Cancer Immunology Research. 10:P049-P049
Background: The stimulator of interferon genes (STING) plays a central role in innate immune response against infection and cancer. Naturally, the cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS)-STING pathway adopts pol
Autor:
Xiaoyi Jiang, Jian Wang, Xichen Zheng, Zhida Liu, Xinyu Zhang, Yuwei Li, Jonathan Wilhelm, Jun Cao, Gang Huang, Jinlan Zhang, Baran Sumer, Jayanthi Lea, Zhigang Lu, Jinming Gao, Min Luo
Publikováno v:
Journal for ImmunoTherapy of Cancer. 10:e003960
BackgroundCancer vaccines are able to achieve tumor-specific immune editing in early-phase clinical trials. However, the infiltration of cytotoxic T cells into immune-deserted tumors is still a major limiting factor. An optimized vaccine approach to