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pro vyhledávání: '"Jonathan Widdicombe"'
Autor:
Jonathan Widdicombe
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 317:L486-L495
This article traces the beginnings of the various areas of physiological research on airway epithelium. First mentioned in 1600, it was not until 1834 that it was found to be ciliated. Goblet and basal cells were described in 1852, to be followed by
Autor:
Jonathan Widdicombe
Publikováno v:
Chronic Obstr Pulm Dis
Chronic obstructive pulmonary diseases (Miami, Fla.), vol 7, iss 4
Chronic obstructive pulmonary diseases (Miami, Fla.), vol 7, iss 4
Chronic bronchitis is associated with hypertrophy of airway submucosal glands and with mucus and squamous metaplasia of the surface epithelium. A historical review of research on these and other pathological changes is provided. Next, from annual rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7534d63cfda013116eaf242e7bb10b
https://europepmc.org/articles/PMC7883910/
https://europepmc.org/articles/PMC7883910/
Autor:
Jonathan Widdicombe
Publikováno v:
Developmental Cell. 54:427-428
In this issue of Developmental Cell, Xie et al. show that in cystic fibrosis, airway gland mucus gels form under conditions of high acidity and protein concentration. This causes them to be unusually stiff. This abnormal rheology cannot be corrected
Autor:
Mohammad Hajighasemi-Ossareh, Jonathan Widdicombe, Jeremy E. Stevens, Walter E. Finkbeiner, Rachel M. Borthwell
Publikováno v:
The Anatomical Record. 296:1768-1774
A transgenic ferret model of cystic fibrosis has recently been generated. It is probable that malfunction of airway mucous glands contributes significantly to the airway pathology of this disease. The usefulness of the ferret model may therefore depe
Autor:
Jonathan Widdicombe
Publikováno v:
Colloquium Series on Integrated Systems Physiology: From Molecule to Function. 4:1-148
Autor:
Lorna Zlock, Anna Y. Lao, Vijay Dasari, Walter E. Finkbeiner, Jonathan Widdicombe, Masatoshi Morikawa
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 301:L402-L414
—We investigated how cystic fibrosis (CF) alters the relationship between Cl−and mucin secretion in cultures of non-CF and CF human tracheobronchial gland mucous (HTGM and CFTGM, respectively) cells. Biochemical studies showed that HTMG cells sec
Autor:
L. A. Sachs, Marrah E. Lachowicz-Scroggins, Jonathan Widdicombe, David P. Schnurr, Shigeo Yagi
Publikováno v:
Journal of Virological Methods. 171:212-218
The development of a quantitative real-time PCR (qPCR) assay for human rhinovirus serotype 16 (HRV16) is described using the plasmid pR16.11, which contains the full-length genome of HRV16. A standard curve was generated by plotting the critical thre
Autor:
Jonathan Widdicombe
Publikováno v:
Journal of Clinical Investigation. 120:3093-3096
Cystic fibrosis (CF) is caused by defects in the CFTR, a cAMP-activated Cl- channel of epithelia. The resulting reduction in epithelial fluid transport creates abnormally viscous secretions from airway mucous glands that may be a major factor in CF p
Autor:
I. S. Pecson, Jonathan Widdicombe
Publikováno v:
Equine Veterinary Journal. 34:630-633
Horses commonly suffer from respiratory diseases associated with excess secretions in the airway lumen, some of which are presumably derived from airway mucous glands. However, these structures have been little investigated in the horse. Accordingly,
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 292:L1432-L1443
Salt and water absorption and secretion across the airway epithelium are important for maintaining the thin film of liquid lining the surface of the airway epithelium. Movement of Cl across the apical membrane involves the CFTR Cl channel; however, c