Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jonathan Whisenant"'
Autor:
Matthew Gumbleton, Stephanie Allan, Hannah Conway, Kenneth Boucher, James Marvin, Josiah Hawks, William Burnett, Matthew Van Brocklin, Jonathan Whisenant, Glynn Gilcrease, Sumati Gupta
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)
Abstract Objective APPEASE is a phase I study to assess the safety, dosing, and efficacy of rivoceranib (a selective, small-molecule inhibitor of VEGFR2) in combination with pembrolizumab. We aimed to treat patients with metastatic malignancies who h
Externí odkaz:
https://doaj.org/article/3b84d4bfc1444b82a42e5349d4039e37
Autor:
David D Stenehjem, Courtney C Cavalieri, Eric Swanson, Benjamin Solomon, Jonathan Whisenant, Dao Tran, John Weis, G Weldon Gilcrease, Sunil Sharma, Ignacio Garrido-Laguna
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Pp 1-6 (2018)
Background: Tumors with deficient mismatch repair (dMMR) have a favorable immunological phenotype permitting exploitation by immunotherapies. We aimed to assess our institutional experience of dMMR advanced gastrointestinal (GI) cancers treated with
Externí odkaz:
https://doaj.org/article/518196c78f6e47e7b0d8093b057286ec
Autor:
Sabina Swierczek, Archana M. Agarwal, Kubendran Naidoo, Felipe R. Lorenzo, Jonathan Whisenant, Roberto H. Nussenzveig, Neeraj Agarwal, Theresa L. Coetzer, Josef T. Prchal
Publikováno v:
Haematologica, Vol 98, Iss 12 (2013)
Hereditary pyropoikilocytosis is a severe hemolytic anemia caused by spectrin deficiency and defective spectrin dimer self-association, typically found in African populations. We describe two Utah families of northern European ancestry including 2 pr
Externí odkaz:
https://doaj.org/article/84da8e1ff41e4a21b2ef2805f6df9df7
Autor:
Jonathan Whisenant, Kevin Burgess
Publikováno v:
Chemical Society reviews. 51(14)
Relatively small mimics of interface secondary structures can be used to disrupt protein-protein interactions (PPIs). This strategy is valuable because many PPIs are pivotal in cell biology and contemporary medicinal chemistry. Small peptides tend to
Publikováno v:
Angew Chem Int Ed Engl
Secondary structures tend to be recognizable because they have repeating structural motifs, but mimicry of these does not have to follow such well-defined patterns. Bioinformatics studies to match side-chain orientations of a novel hydantoin triazole
Autor:
John R. Weis, Alison Fraser, Ken R. Smith, David Baraghoshi, John Snyder, Kerry Rowe, Niloy Jewel Samadder, Courtney L. Scaife, Mia Hashibe, Michael Newman, Thomas Bartley Pickron, Lyen C. Huang, Marcus M. Monroe, Glynn Weldon Gilcrease, Jonathan Whisenant, Sarah Abdelaziz, Shane Lloyd, Ignacio Garrido-Laguna, Randa Tao, Vikrant Deshmukh
Publikováno v:
American Journal of Clinical Oncology. 42:355-362
To determine the risk and risk factors for mental illness among colorectal cancer (CRC) survivors across short-term and long-term follow-up periods.We used the Utah Cancer Registry to identify CRC survivors diagnosed between 1997 and 2013. Mental hea
Autor:
Mona Foth, Courtney C. Cavalieri, Lance D. Burrell, Stephanie L. Cutler, Conan G. Kinsey, Kajsa E. Affolter, Jill E. Shea, Amelie M. Boespflug, Kaitrin M. Rehbein, Alana L. Welm, Jeffrey T. Yap, Bryan E. Welm, Michael T. Seipp, Sophia S. Schuman, Jonathan Whisenant, G. Weldon Gilcrease, Amanda Truong, David H. Lum, Katrin P. Guillen, Courtney L. Scaife, Martin McMahon, Eric L. Snyder, Soledad A. Camolotto
Publikováno v:
Nature medicine
Pancreatic ductal adenocarcinoma (PDA) was responsible for ~ 44,000 deaths in the United States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS1–4. Downstream of KRAS, the RAF→MEK→
Autor:
Ignacio Garrido-Laguna, Glynn Weldon Gilcrease, Vaia Florou, Patricia Maeda, Jonathan Whisenant, Christopher Nevala-Plagemann
Publikováno v:
Journal of the National Comprehensive Cancer Network : JNCCN. 19(5)
NTRK gene fusions are found in ETV6-NTRK3 fusion and initiated TRK-targeted therapy using entrectinib. Upon disease progression, we performed tumor genetic sequencing that showed a secondary resistance mutation. The patient subsequently responded to
Autor:
Jonathan Whisenant, Kevin Burgess
Publikováno v:
ACS Medicinal Chemistry Letters
Recent crystal structure data for protein-protein interactions featuring the SARS-CoV-2 spike protein will inevitably trigger a new wave of research in this area that was not possible before. This Viewpoint outlines a few of the ways that it is alrea
Autor:
G. Weldon Gilcrease, Kelli M. Thorne, David D. Stenehjem, Mark Wade, Kimberly McGregor, Sunil Sharma, Ignacio Garrido-Laguna, Jonathan Whisenant, Kenneth M. Boucher, Nicole Orgain, John R. Weis
Publikováno v:
Investigational New Drugs. 37:482-489
Background This phase I/II trial evaluated toxicity and antitumor activity of everolimus plus mFOLFOX6 + bevacizumab for first-line treatment of metastatic colorectal cancer (mCRC). Methods A phase I, modified 3 + 3 Fibonacci schema determined the ma