Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Jonathan Wesley Nyce"'
1
The Purpose of Adrenarche Is Tumor Suppression: Identification of a Novel, Human-Specific, Kill-Switch Tumor Suppression Mechanism Dependent upon the Dramatic Adrenarchal Rise of Adrenal Androgens
Autor: Jonathan Wesley Nyce
Adrenarche is a developmental phase that occurs only in humans and chimpanzees. It is characterized by the maturation of the adrenal zona reticularis, culminating in the synthesis and secretion of enormous amounts of dehydroepiandro-sterone sulfate (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eed89b4c764b885013b2767732d0012
https://doi.org/10.20944/preprints202304.0253.v1
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2
Alert to US physicians: DHEA, widely used as an OTC androgen supplement, may exacerbate COVID-19
Autor: Jonathan Wesley Nyce
Publikováno v: Endocrine-related cancer. 28(2)
Androgens play a fundamental role in the morbidity and mortality of COVID-19, inducing both the ACE-2 receptor to which SARS-CoV-2 binds to gain entry into the cell, and TMPRS22, the transmembrane protease that primes the viral spike protein for effi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeae7579c15fd0cc613f6455be0599ce
https://pubmed.ncbi.nlm.nih.gov/33263566
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3
Detection of a novel, primate-specific ‘kill switch’ tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53
Autor: Jonathan Wesley Nyce
Publikováno v: Endocrine-Related Cancer
The activation of TP53 is well known to exert tumor suppressive effects. We have detected aprimate-specificadrenal androgen-mediated tumor suppression system in which circulating DHEAS is converted to DHEA specifically in cells in which TP53 has been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00e1b8e0ebec73602ac81c1e50f45dd
http://europepmc.org/articles/PMC6106910
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4
A lex naturalis delineates components of a human-specific, adrenal androgen-dependent, p53-mediated ‘kill switch’ tumor suppression mechanism
Autor: Jonathan Wesley Nyce
Publikováno v: Endocrine-Related Cancer
We have recently described in this journal our detection of an anthropoid primate-specific, adrenal androgen-dependent, p53-mediated, ‘kill switch’ tumor suppression mechanism that reached its fullest expression only in humans, as a result of hum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1b55a92e002c3b7e948dd730eb1af0
https://doi.org/10.1530/erc-19-0382a
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5
Species-specific mechanisms of tumor suppression are fundamental drivers of vertebrate speciation: critical implications for the 'war on cancer'
Autor: Jonathan Wesley Nyce
Publikováno v: Endocrine-Related Cancer
We recently reported our detection of an anthropoid primate-specific, ‘kill switch’ tumor suppression system that reached its greatest expression in humans, but that is fully functional only during the first twenty-five years of life, correspondi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3bc7cf7b617bd733be03e12b9f7949
https://pubmed.ncbi.nlm.nih.gov/30400061
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