Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Jonathan W. Jarvik"'
Autor:
Daniel S. Ackerman, Ezgi Pinar Yalcintas, Emrullah Korkmaz, Marcel P. Bruchez, Cheryl A. Telmer, O. Burak Ozdoganlar, Jonathan W. Jarvik, Phil G. Campbell
Publikováno v:
Pharmaceutical Research. 37
Dissolvable microneedle arrays (MNAs) can be used to realize enhanced transdermal and intradermal drug delivery. Dissolvable MNAs are fabricated from biocompatible and water-soluble base polymers, and the biocargo to be delivered is integrated with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a05954d70383fb337a73871895ae55b
https://doi.org/10.1007/s11095-019-2748-7
https://doi.org/10.1007/s11095-019-2748-7
Autor:
Jonathan W. Jarvik, Lianne B. Cohen, Kalin V. Vasilev, Daniel S. Ackerman, Brigitte F. Schmidt
Publikováno v:
Bioconjugate Chemistry. 28:1356-1362
We describe proof-of-concept for a novel approach for visualizing regions of close apposition between the surfaces of living cells. A membrane-anchored protein with high affinity for a chemical ligand is expressed on the surface of one set of cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0426c136460c09e1ecb96c23b6ae0d
https://doi.org/10.1021/acs.bioconjchem.7b00047
https://doi.org/10.1021/acs.bioconjchem.7b00047
Autor:
Marcel P. Bruchez, Andrew Tsourkas, Burcin Altun, Daniel S. Ackerman, Jonathan W. Jarvik, Dmytro Kolodieznyi
Publikováno v:
Bioconjugate chemistry. 30(1)
We demonstrate selective labeling of cell surface proteins using fluorogen-activating proteins (FAPs) conjugated to standard immunoglobulins (IgGs). Conjugation was achieved with a polypeptide reagent comprised of an N-terminal photoactivatable Fc-bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9c1e99f3263c7901a98eb72dc54860
https://pubmed.ncbi.nlm.nih.gov/30543409
https://pubmed.ncbi.nlm.nih.gov/30543409
Autor:
Gregory W. Fisher, Kristine Gouveia, Yang Wu, Shaun R. Stauffer, Alan S. Waggoner, Christopher Szent-Gyorgyi, Annette M. Evangelisti, Mike Poslusney, Cristian Bologa, Larry A. Sklar, Craig W. Lindsley, Anna Waller, Oleg Ursu, Jonathan W. Jarvik, Robyn L. Stanfield, Phillip H. Tapia, J. Jacob Strouse, Mark B. Carter
Publikováno v:
SLAS Discovery. 21:74-87
A new class of biosensors, fluorogen activating proteins (FAPs), has been successfully used to track receptor trafficking in live cells. Unlike the traditional fluorescent proteins (FPs), FAPs do not fluoresce unless bound to their specific small-mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6370374a2170d95abf28784c8d4b965
https://doi.org/10.1177/1087057115609145
https://doi.org/10.1177/1087057115609145
Autor:
Peter V Moulder, Xuemei Zeng, Selma F. Witchel, Jonathan W. Jarvik, Steven F. Dobrowolski, Cheryl A. Telmer
Congenital adrenal hyperplasia (CAH) is a common inborn error of steroidogenesis. The clinical spectrum of CAH ranges from the severe classical form, which can be fatal in the newborn, to simple virilizing forms or a milder non-classical form which i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d0fd81cd56ceaffd4a34d86c8ea21d
Autor:
Eugenio Gallo, Jonathan W. Jarvik
Publikováno v:
Journal of cell science. 130(15)
A novel bi-partite fluorescence platform exploits the high affinity and selectivity of antibody scaffolds to capture and activate small-molecule fluorogens. In this report, we investigated the property of multi-selectivity activation by a single anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81283b966a4a7c42ffc00aa6cd8681e
https://pubmed.ncbi.nlm.nih.gov/28615413
https://pubmed.ncbi.nlm.nih.gov/28615413
Publikováno v:
Biotechnology and Bioengineering. 111:475-484
Fluorogen-activating-proteins (FAPs) are a novel platform of fluorescence biosensors utilized for protein discovery. The technology currently demands molecular manipulation methods that limit its application and adaptability. Here, we highlight an al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d756595b1faeb9e9145626caf2b8370f
https://doi.org/10.1002/bit.25127
https://doi.org/10.1002/bit.25127
Autor:
Jonathan W. Jarvik, Margaret H. Fuhrman, Marcel P. Bruchez, Gregory W. Fisher, Alan S. Waggoner, Sally A. Adler
Publikováno v:
SLAS Discovery. 15:703-709
Ligand-dependent receptor internalization is a feature of numerous signaling systems. In this article, the authors describe a new kind of live-cell biosensor of receptor internalization that takes advantage of fluorogen-activating protein (FAP) techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c9375ed35f2606a14df9cee0135659
https://doi.org/10.1177/1087057110370892
https://doi.org/10.1177/1087057110370892
Autor:
Margaret H. Fuhrman, Gregory W. Fisher, Sally A. Adler, Dara Brown, Jonathan W. Jarvik, John P. Holleran
Publikováno v:
Cytometry Part A. :776-782
This study explores the general utility of a new class of biosensor that allows one to selectively visualize molecules of a chosen membrane protein that are at the cell surface. These biosensors make use of recently described bipartite fluoromodules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1549b7e262549dba1b72895b554906e2
https://doi.org/10.1002/cyto.a.20925
https://doi.org/10.1002/cyto.a.20925
Autor:
Christopher, Szent-Gyorgyi, Brigitte F, Schmidt, Brigitte A, Schmidt, Yehuda, Creeger, Gregory W, Fisher, Kelly L, Zakel, Sally, Adler, James A J, Fitzpatrick, Carol A, Woolford, Qi, Yan, Kalin V, Vasilev, Peter B, Berget, Marcel P, Bruchez, Jonathan W, Jarvik, Alan, Waggoner
Publikováno v:
Nature Biotechnology. 26:235-240
Imaging of live cells has been revolutionized by genetically encoded fluorescent probes, most famously green and other fluorescent proteins, but also peptide tags that bind exogenous fluorophores. We report here the development of protein reporters t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98186956edbae54d83b5474050ddfb4
https://doi.org/10.1038/nbt1368
https://doi.org/10.1038/nbt1368