Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jonathan W. Cruz"'
Autor:
Jonathan W. Cruz, Ermelinda Damko, Bhavika Modi, Naxin Tu, Karoline Meagher, Vera Voronina, Hans Gartner, George Ehrlich, Ashique Rafique, Robert Babb, Priya Aneja, Terra B. Potocky, Amanda D’ Orvilliers, Alida Coppi, Sook Yen E, Haibo Qiu, Courtney M. Williams, Brandy L. Bennett, Gang Chen, Lynn Macdonald, William Olson, John C. Lin, Neil Stahl, Andrew J. Murphy, Christos A. Kyratsous, Brinda C. Prasad
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Abstract Harnessing complement-mediated cytotoxicity by therapeutic antibodies has been limited because of dependency on size and density of antigen, structural constraints resulting from orientation of antibody binding, and blockade of complement ac
Externí odkaz:
https://doaj.org/article/a1c56187022f4047924380652a772499
Autor:
Robert Haupt, David C. Lye, Stuart Weston, Natasha Levenkova, Matthew B. Frieman, Kristen E. Pascal, Kei Saotome, Wen-Yi Lee, Richard Welsh, Bojie Zhang, Alina Baum, Vincenzo Russo, Krunal Patel, Gang Chen, Christen Libertiny, Annabel Romero Hernandez, Seth Pennington, Yi Zhou, Johanna Hansen, Tammy T. Huang, Sumathi Sivapalasingam, Kyung Min Chung, Matthew C. Franklin, Stephanie Giordano, Dipali Deshpande, Jeanette L. Fairhurst, Andrew J. Murphy, Erica Ullman, George D. Yancopoulos, Jonathan W. Cruz, Glen Farr, Marine Malbec, Jemmie Cheng, William C. Olson, Pascal Bouffard, Ying Yan, Elzbieta Wloga, James Logue, Calvin R. Chen, Benjamin O. Fulton, Aynur Hermann, Anke Watty, Ashique Rafique, Robert Babb, Katrina Koon, Neil Stahl, Christos A. Kyratsous
Publikováno v:
Science (New York, N.y.)
Science
Science
Neutralizing antibodies have become an important tool in treating infectious diseases. Recently, two separate approaches yielded successful antibody treatments for Ebola-one from genetically humanized mice and the other from a human survivor. Here, w
Autor:
Christos A. Kyratsous, Ermelinda Damko, John C. Lin, Karoline A Meagher, Robert Babb, Haibo Qiu, Sook Yen E, Priya Aneja, Ashique Rafique, Courtney M. Williams, Macdonald Lynn, Hans Gartner, Andrew J. Murphy, Amanda D’ Orvilliers, Jonathan W. Cruz, Vera Voronina, Bhavika Modi, Alida Coppi, Gang Chen, Neil Stahl, Naxin Tu, George Ehrlich, Brinda Prasad, Brandy L. Bennett, Terra Potocky, William C. Olson
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports
Scientific Reports
Harnessing complement-mediated cytotoxicity by therapeutic antibodies has been limited because of dependency on size and density of antigen, structural constraints resulting from orientation of antibody binding, and blockade of complement activation
Autor:
Valdir C. Barth, Nancy A. Woychik, Robert N. Husson, Ju Mei Zeng, Melvilí Cintrón, Jonathan W. Cruz
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
The Mycobacterium tuberculosis genome harbors an unusually high number of toxin-antitoxin (TA) systems. These TA systems have been implicated in establishing the nonreplicating persistent state of this pathogen during latent tuberculosis infection. M
Autor:
Regina Edifor, Nancy A. Woychik, Robert N. Husson, Irina O. Vvedenskaya, Bryce E. Nickels, Jonathan W. Cruz, Jason M. Schifano, Ming Ouyang
Publikováno v:
Nucleic Acids Research
Toxin-antitoxin (TA) systems play key roles in bacterial persistence, biofilm formation and stress responses. The MazF toxin from the Escherichia coli mazEF TA system is a sequence- and single-strand-specific endoribonuclease, and many studies have l
Autor:
Robert N. Husson, Nancy A. Woychik, Jared D. Sharp, Irina O. Vvedenskaya, Arvind Konkimalla, Jonathan W. Cruz, Eric D. Hoffer, Bryce E. Nickels, Christine M. Dunham, Tatsuya Maehigashi
Publikováno v:
Nature Communications. 6
Toxin-antitoxin (TA) systems are implicated in the downregulation of bacterial cell growth associated with stress survival and latent tuberculosis infection, yet the activities and intracellular targets of these TA toxins are largely uncharacterized.
Autor:
Nancy A. Woychik, Jonathan W. Cruz
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 10, Iss 9, p e1004349 (2014)
PLoS Pathogens, Vol 10, Iss 9, p e1004349 (2014)
The Fic (filamentation induced by cAMP) family of proteins comprises several thousand members that are found in all domains of life [1], [2]. In bacteria, these proteins are often expressed by pathogens as virulence factors that disrupt signaling in
Autor:
Christine M. Dunham, Nancy A. Woychik, Jonathan W. Cruz, Francesca P. Rothenbacher, Tatsuya Maehigashi, William S. Lane
Publikováno v:
The Journal of biological chemistry. 289(11)
The Doc toxin from bacteriophage P1 (of the phd-doc toxin-antitoxin system) has served as a model for the family of Doc toxins, many of which are harbored in the genomes of pathogens. We have shown previously that the mode of action of this toxin is
The enzymatic activity of the RelE bacterial toxin component of the Escherichia coli RelBE toxin-antitoxin system has been extensively studied in vitro and to a lesser extent in vivo. These earlier reports revealed that 1) RelE alone does not exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52295352b3602027b948e41b4b6b03fd
https://europepmc.org/articles/PMC3083149/
https://europepmc.org/articles/PMC3083149/
Autor:
Thomas J. Montville, Jonathan W. Cruz
Publikováno v:
Journal of food protection. 71(1)
The influence of nisin on the heat and pressure resistance of Bacillus anthracis Sterne spores was examined. The decimal reduction times (D-value) of spores in milk (2% fat) at 80, 85, and 90 degrees C were determined. In the absence of nisin, the D-