Zobrazeno 1 - 10
of 498
pro vyhledávání: '"Jonathan W, Said"'
Autor:
Ling-Wen Ding, Qiao-Yang Sun, Jarem J. Edwards, Lucia Torres Fernández, Xue-Bin Ran, Si-Qin Zhou, Richard A. Scolyer, James S. Wilmott, John F. Thompson, Ngan Doan, Jonathan W. Said, Nachiyappan Venkatachalam, Jin-Fen Xiao, Xin-Yi Loh, Maren Pein, Liang Xu, David W. Mullins, Henry Yang, De-Chen Lin, H. Phillip Koeffler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
LNK is a tumor suppressor in hematopoietic cancers, but its function in melanoma is unclear. Here, the authors show that the overexpression of LNK in melanomas correlate with hyperactive signaling of the RAS-RAF-MEK pathway and LNK enhances melanoma
Externí odkaz:
https://doaj.org/article/87746954caf641c38aaf967ff326924d
Autor:
Ye Chen, Liang Xu, Anand Mayakonda, Mo-Li Huang, Deepika Kanojia, Tuan Zea Tan, Pushkar Dakle, Ruby Yu-Tong Lin, Xin-Yu Ke, Jonathan W. Said, Jianxiang Chen, Sigal Gery, Ling-Wen Ding, Yan-Yi Jiang, Angela Pang, Mark Edward Puhaindran, Boon Cher Goh, H. Phillip Koeffler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Liposarcoma (LPS) is a rare cancer that can acquire resistance to chemotherapy. Here, the authors map super-enhancers in LPS, finding BET-protein dependent mechanisms that can be targeted by a BET protein degrader, which also can overcome acquired re
Externí odkaz:
https://doaj.org/article/737f0325add94122b8c3c1a96fabd32f
Autor:
Xue-Bin Ran, Ling-Wen Ding, Qiao-Yang Sun, Henry Yang, Jonathan W. Said, Lao Zhentang, Vikas Madan, Pushkar Dakle, Jin-Fen Xiao, Xinyi Loh, Ying Li, Liang Xu, Xiao-Qiang Xiang, Ling-Zhi Wang, Boon Cher Goh, De-Chen Lin, Wee Joo Chng, Soo-Yong Tan, Sudhakar Jha, H. Phillip Koeffler
Publikováno v:
Cancer Research. 83:922-938
Despite the remarkable clinical responses achieved with immune checkpoint blockade therapy, the response rate is relatively low and only a subset of patients can benefit from the treatment. Aberrant RNA accumulation can mediate IFN signaling and stim
Autor:
Deepika Kanojia, Manoj Garg, Jacqueline Martinez, Anand M.T., Samuel B. Luty, Ngan B. Doan, Jonathan W. Said, Charles Forscher, Jeffrey W. Tyner, H. Phillip Koeffler
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-13 (2017)
Abstract Background Liposarcoma, the most common soft tissue tumor, is understudied cancer, and limited progress has been made in the treatment of metastatic disease. The Achilles heel of cancer often is their kinases that are excellent therapeutic t
Externí odkaz:
https://doaj.org/article/cbeccdd37dc645c3a7163841fa5e5639
Autor:
Vikas Madan, Lin Han, Norimichi Hattori, Weoi Woon Teoh, Anand Mayakonda, Qiao-Yang Sun, Ling-Wen Ding, Hazimah Binte Mohd Nordin, Su Lin Lim, Pavithra Shyamsunder, Pushkar Dakle, Janani Sundaresan, Ngan B. Doan, Masashi Sanada, Aiko Sato-Otsubo, Manja Meggendorfer, Henry Yang, Jonathan W. Said, Seishi Ogawa, Torsten Haferlach, Der-Cherng Liang, Lee-Yung Shih, Tsuyoshi Nakamaki, Q. Tian Wang, H. Phillip Koeffler
Publikováno v:
Haematologica, Vol 103, Iss 12 (2018)
Chromosomal translocation t(8;21)(q22;q22) which leads to the generation of oncogenic RUNX1-RUNX1T1 (AML1-ETO) fusion is observed in approximately 10% of acute myelogenous leukemia (AML). To identify somatic mutations that co-operate with t(8;21)-dri
Externí odkaz:
https://doaj.org/article/ab6ad18f04b84ee8a7ee0e0cf60a7d89
Autor:
H. Phillip Koeffler, Jiang Gu, Jonathan W. Said, Ngan B. Doan, Steven A. Miles, Rocio Alvarez, Ryoko Okamoto, Glenn D. Braunstein, Sigal Gery, Conghui Zhao, Yan Zhou
PDF - 60KB, Antibodies for Western blotting.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e2cc814b6749970f8e9f27467eb6af
https://doi.org/10.1158/1535-7163.22503465
https://doi.org/10.1158/1535-7163.22503465
Autor:
H. Phillip Koeffler, Jiang Gu, Jonathan W. Said, Ngan B. Doan, Steven A. Miles, Rocio Alvarez, Ryoko Okamoto, Glenn D. Braunstein, Sigal Gery, Conghui Zhao, Yan Zhou
PDF - 3892KB, Molecular structure of Cizotinib, Tivantinib, and SU11274.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1fa00a7544240f8108f9f24efb0e22
https://doi.org/10.1158/1535-7163.22503471.v1
https://doi.org/10.1158/1535-7163.22503471.v1
Autor:
H. Phillip Koeffler, Jiang Gu, Jonathan W. Said, Ngan B. Doan, Steven A. Miles, Rocio Alvarez, Ryoko Okamoto, Glenn D. Braunstein, Sigal Gery, Conghui Zhao, Yan Zhou
PDF - 3009KB, Effect of Tivantinib and Crizotinib on cell growth and c-MET phosphorylation of MDA-MB-231 and HT29 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd39dd89a0a0cf7d08e917572bbf6f0
https://doi.org/10.1158/1535-7163.22503468
https://doi.org/10.1158/1535-7163.22503468
Autor:
H. Phillip Koeffler, Jeffrey W. Tyner, Charles Forscher, Anand Mayakonda, Marilynn Chow, Sigal Gery, Jonathan W. Said, Ngan Doan, Huey Jin Lim, Victor Kwan Min Lee, David D. Gae, Brendan Pang, Qi Cao, De-Chen Lin, Haibo Sun
Fig. S1. GSEA analysis revealed significant enrichment of gene associated with genomic unstable EWS phenotype (A), cell cycle (B) and NF-κB (C) in SYK knockdown cells, and gene associated with metastasis (D) in cells treated with the SYK inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab0ab41a53fa1084607efb20ad68eda
https://doi.org/10.1158/1078-0432.22468367.v1
https://doi.org/10.1158/1078-0432.22468367.v1
Autor:
H. Phillip Koeffler, Sudhakar Jha, Soo-Yong Tan, Wee Joo Chng, De-Chen Lin, Boon Cher Goh, Ling-Zhi Wang, Xiao-Qiang Xiang, Liang Xu, Ying Li, Xinyi Loh, Jin-Fen Xiao, Pushkar Dakle, Vikas Madan, Lao Zhentang, Jonathan W. Said, Henry Yang, Qiao-Yang Sun, Ling-Wen Ding, Xue-Bin Ran
Despite the remarkable clinical responses achieved with immune checkpoint blockade therapy, the response rate is relatively low and only a subset of patients can benefit from the treatment. Aberrant RNA accumulation can mediate IFN signaling and stim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e30226bbafd81426fb0486f48ce479f
https://doi.org/10.1158/0008-5472.c.6514200.v1
https://doi.org/10.1158/0008-5472.c.6514200.v1